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Compositions and methods for treating alzheimer's disease and parkinson's disease

a technology for parkinson's disease and alzheimer's disease, applied in the field of pharmaceutical compositions for treating alzheimer's disease and parkinson's disease, can solve the problems of inability to achieve the desired effect of clinical trials, interfere with a person's daily life and activities, and achieve the effects of reducing, preventing and/or eliminating one or more symptoms

Pending Publication Date: 2022-03-31
LA PHARMATECH INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The patent is about a pharmaceutical composition that can help treat Alzheimer's disease and Parkinson's disease in patients. It contains a combination of azelastine, a type of medication, and methylcobalamin, a type of vitamin. This combination can help alleviate, reduce, prevent, or eliminate symptoms of the diseases.

Problems solved by technology

Dementia is the loss of cognitive functioning—thinking, remembering, and reasoning—and behavioral abilities to such an extent that it interferes with a person's daily life and activities.
If untreated, AD ultimately leads to death.
So far, all promising approaches for decreasing Aβ or p-tau levels including mechanisms such as inhibition of Aβ or p-tau generation, reduction of soluble Aβ levels and enhancement of Aβ or p-tau clearance from the CNS have not provided desired outcomes from their clinical trials.
While development of Aβ based treatments follows logically from known Aβ mechanisms, a number of factors might limit the effectiveness of such treatments if applied in isolation.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

examples

[0060]A 70 year old patient with mid-stage Alzheimer's disease (AD) for 2 years and before treatment a baseline MMSE score of 12 and a Barthel Index (BI) of Activities of Daily Living score of 30, can be treated with a pharmaceutical composition of methylcobalamin and azelastine, e.g., a composition comprising methylcobalamin in an amount of 1.0 mg and azelastine, azelastine HCl or other salt thereof in an amount of 8 mg, up to twice daily (or any of the compositions described above or claimed, or for any treatment protocol or period of time described above or claimed). After 2 weeks, 3 weeks, 4 weeks, 5 weeks, 6 weeks, 7 weeks, 8 weeks, or more, one or more of his AD symptoms would be expected to improve by at least 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 100% or higher. For example, his MMSE score would be expected to improve from 12 to at least 22, which is an 83% improvement, and his BI score would be expected to improve from 30 to at least 80, which is a 167% improvement. ...

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Abstract

Pharmaceutical compositions comprising azelastine, or a pharmaceutically acceptable salt of azelastine, and methylcobalamin are disclosed. Methods of using the pharmaceutical compositions for treating patients with Alzheimer's disease or Parkinson's disease are also disclosed.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]The present application is a Continuation application of U.S. patent application Ser. No. 16 / 913,927 filed Jun. 26, 2020, which published as U.S. Patent Application Publication No. 2020 / 0323873 on Oct. 15, 2020. The '927 application is a Continuation in Part application of U.S. patent application Ser. No. 16 / 382,885 filed on Apr. 12, 2019, which issued as U.S. Pat. No. 10,966,989 on Apr. 6, 2021, the disclosures of which are hereby incorporated by reference herein in their entireties.FIELD OF THE INVENTION[0002]The present invention relates to the field of practical medicine, namely, to the use of pharmaceutical compositions for treatment of Alzheimer's disease and Parkinson's disease. More specifically, the invention relates to novel combinations of compounds which can effectively treat Alzheimer's disease (AD) and Parkinson's disease (PD).BACKGROUND OF THE INVENTION[0003]Alzheimer's disease (AD) is a progressive, chronic neurodegenerati...

Claims

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Application Information

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IPC IPC(8): A61K31/55A61K31/714
CPCA61K31/55A61K9/0053A61K31/714
Inventor WANG, JIANMINCUI, GEPING
Owner LA PHARMATECH INC
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