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Nutritional or therapeutic compositions to increase bodily glutathione levels

a technology of bodily glutathione and composition, which is applied in the field of nutritional or therapeutic compositions, can solve the problems of not being synthesized intracellularly, unable to absorb individual cells as such, and unable to achieve the effect of enhancing the immune activity of a mammal, increasing the production of glutathione, and increasing the formation of glutathion

Inactive Publication Date: 2007-07-17
CRUM ALBERT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0018]The compositions will be utilized to increase the formation of glutathione and thus to enhance the immune activity of a mammal in need of such treatment. The effect of the treatment is such that after the treatment, the mammal will be more resistant to microbial infection or other trauma adversely affecting immune activity than before such treatment.

Problems solved by technology

It is known that insufficient levels of glutathione may result in the onset of numerous diseases.
Even if some of the tripeptide gets through the gastrointestinal wall intact, it is questionable whether it can be absorbed as such into the individual cell, rather than being synthesized intracellularly.

Method used

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  • Nutritional or therapeutic compositions to increase bodily glutathione levels

Examples

Experimental program
Comparison scheme
Effect test

example 1 (

TABLET)

[0050]

Ingredients:89mgcystine75mgglycine147mgglutamic acid22.5μgpolyvinylpyrolidone61.25mglactose4.5mlalcohol SD3A-200 proof9mgstearic acid42.3mgcorn starch10μgselenium methionine

[0051]Blend the cystine, glycine, glutamic acid, polyvinylpyrrolidone and lactose together and pass through a 40 mesh screen. Add the alcohol slowly and knead well. Screen the wet mesh through a 4 mesh screen. Dry the granulation at 50 degrees centigrade for 10 hours. Pass the mixture of stearic acid, corn starch and selenium compound through a 60 mesh screen and tumble with the granulation until all the ingredients are well mixed. Compress using a 7 / 16 inch standard concave punch.

example 2 (

TABLET)

[0052]

Ingredients:178mgcystine150mgglycine294mgglutamic acid5μgselenium methionine126mglactose78mgpotato starch96mgethyl cellulose54mgstearic acid

[0053]Thoroughly mix the ingredients in a blender, dry, put through a 12 mesh screen and compress into tablet using a 13 / 32 inch concave punch.

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Abstract

Nutritional or therapeutic compositions containing glutamic acid, cystine, glycine and a selenium precursor and methods for their utilization to increase glutathione synthesis and thereby enhance the immune system are described.

Description

[0001]Notice: More than one reissue application has been filed for the reissue of U.S. Pat. No. 6,592,908. The reissue applications are application Ser. Nos. 11 / 181,001 (present application), filed on Jul. 13, 2005, and 11 / 371,804, filed on Mar. 9, 2006, which is a divisional reissue of U.S. Pat. No. 6,592,908.FIELD OF THE INVENTION[0002]This invention relates to nutritional or therapeutic compositions useful for treating mammals to increase their body content of glutathione above a pretreatment level thereby to enhance the immune activity of the treated mammal. More specifically, it relates to compositions containing a selenium compound together with a glutathione precursor which is a mixture of glutamic acid, cystine and glycine.BACKGROUND OF THE INVENTION[0003]Glutathione is a tripeptide and a major reducing agent in the mammalian body. Its chemical structure is: or, more simplyGLU-CYS-GLY[0004]Its chemical name is glutamyl-cysteinyl-glycine.[0005]Like many other small peptides i...

Claims

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Application Information

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Patent Type & Authority Patents(United States)
IPC IPC(8): A61K31/095A61K31/197A61K31/198A61K33/04A61P3/02A61P37/04A61K45/06
CPCA23L1/304A61K9/2018A61K31/095A61K31/197A61K31/198A61K33/04A61K45/06A23L1/3051Y10S514/905A23V2002/00Y10S514/836A61K2300/00A23V2250/1626A23V2250/06A23L33/16A23L33/175A61P19/02A61P25/28A61P29/00A61P3/00A61P3/02A61P31/18A61P35/00A61P37/00A61P37/02A61P37/04A61P39/06A61P43/00A61P9/10
Inventor CRUM, ALBERT
Owner CRUM ALBERT
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