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Pressure-sensitive adhesive and patch employing the same

Inactive Publication Date: 2016-03-22
HISAMITSU PHARM CO INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The patent is about a new crosslinking agent called boron-containing compound, which can be dissolved in a special solvent and used to give polymers containing no water enough tackifying power and cohesive power. This allows for the creation of desirable physical properties when making patches containing lipophilic drugs or other components.

Problems solved by technology

With regard to a crosslinking agent for a hydroxy group-containing polymer, Japanese Patent No. 2967788 proposes the use of a metal chelate, a metal alcoholate, etc., but since the metal chelate and the metal alcoholate are generally highly reactive, they might decompose or denature the drug during a crosslinking reaction, and skin irritation or more serious symptoms might be caused by residual crosslinking agent.
However, these inorganic compounds have not so far been used for the preparation of a nonaqueous gel because of problems during the preparation such as the inorganic compounds generally having poor solubility in organic solvents.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0052]

DURO-TAK ® (No. 387-2287)4.45g89%Ethyl acetate solution(solids conc.: 50%)Isopropyl myristate0.5g (solids)10%Boric acid [methanol solution (30 mg / mL)]0.05g 1%Total5.0g100% 

[0053]In the above composition, the DURO-TAK® (No. 387-2287, manufactured by National Starch and Chemical Company), which is an acrylic polymer, and isopropyl myristate were mixed, 2 mL of ethyl acetate was added thereto, the mixture was stirred for 1 hour, the boric acid solution was then added thereto, and the mixture was stirred for 5 minutes to give an adhesive layer solution. This was spread out on a silicone-treated surface of an 80 μm thick polyethylene terephthalate (PET) film and crosslinked at 100° C. for 15 minutes to give an 80 μm adhesive layer. As a support, a 30 μm thick sand-matted PET film was laminated so that the sand-matted surface was in contact with the adhesive layer, thus giving a matrix preparation of the present invention. After the preparation thus obtained was stored at 65° C. for...

example 2

[0054]

DURO-TAK ® (No. 387-2287)2.9g (solids)58% Estradiol0.2g4%Norethisterone acetate0.35g7%Isopropyl myristate0.5g10% Polyvinylpyrrolidone1.0g20% Boric acid [methanol solution (30 mg / mL)]0.05g1%Total5.0g100% 

[0055]In the above composition, the estradiol, norethisterone acetate, isopropyl myristate, and polyvinylpyrrolidone were mixed, 2 mL of ethanol was added thereto, the mixture was stirred for 2 hours, the DURO-TAK® and 2 mL of ethyl acetate were then added thereto and dissolved therein, and the mixture was further stirred for 3 hours until a uniform solution was obtained. The boric acid solution was added thereto and stirred for 5 minutes to give an adhesive layer solution. This was spread out in the same manner as in Example 1, and a support layer was laminated to give a matrix preparation of the present invention. After the preparation thus obtained was stored at 65° C. for 48 hours, the adhesive power of the preparation was measured using a probe tack tester, and it was foun...

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Abstract

An adhesive which comprises aqueous and nonaqueous polymers suitable for holding an lipophilic drug, etc., and has tackiness and cohesiveness which are sufficient for the plaster of a patch; and a patch employing the adhesive. The adhesive contains a polymer which comprises one or more kinds of acrylic or methacrylic monomer units, at least one kind of the monomer units having a hydroxy group, and which has been crosslinked with a boron compound.

Description

TECHNICAL FIELD[0001]The present invention relates to an adhesive that is affixed to the surface of skin so as to continuously administer a drug into a living body through the skin, and a patch employing same.BACKGROUND ART[0002]An adhesive layer constituting a patch normally comprises a mixture containing a drug and, as a main component, a polymer, and with regard to means for improving the tackiness and cohesiveness of this mixture, various techniques have been carried out in which a crosslinked polymer is formed by adding an appropriate crosslinking agent during the formulation process so as to gel the adhesive layer. Such an adhesive can be obtained by a method in which a drug, etc. is added to a crosslinked polymer, but in order to add a sufficient amount of drug to the adhesive layer and solve problems in molding, a method in which an appropriate crosslinking agent is added during the formulation process to a mixture containing a drug and, as a main component, a polymer so as ...

Claims

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Application Information

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IPC IPC(8): C08F8/00C09J4/00A61K47/32A61K47/04C09J11/04A61K9/70
CPCA61K9/7069A61K9/7061
Inventor YASUKOCHI, TAKASHIYAMAGUCHI, TOSHIROTATEISHI, TETSUROHIGO, NARUHITO
Owner HISAMITSU PHARM CO INC
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