62 results about "Condylomata acuminatum" patented technology

The invention relates to a truncated L1 protein of the Human Papillomavirus Type 11, a virus-like particle consisting of the protein, a vaccine comprising said virus-like particle, and the use of the vaccine in the prevention of condyloma acuminatum or HPV infections.

The invention relates to mutational HPV33 (human papilloma virus 33) L1 protein (or a mutant thereof), an encoding sequence and a preparation method thereof, and a virus-like particle containing the same. The protein (or the mutant thereof) and the virus-like particle can be used for inducing a neutralizing antibody for resisting at least two types of HPV (such as HPV33 and HPV58, or HPV33, HPV58 and HPV52), so as to prevent the infection of at least two types of HPV and the diseases caused by infection, such as cervical cancer and condyloma acuminatum. The invention also relates to application of the protein and the virus-like particle in preparing a medicine composition or a vaccine. The medicine composition or the vaccine can be used for preventing the infection of at least two types of HPV and the diseases caused by infection, such as cervical cancer and condyloma acuminatum.

The invention relates to the technical field of polypeptide pharmaceutical preparations, and in particular relates to a pharmaceutical composition containing polypeptides F1 and F3 and application of the pharmaceutical composition in treatment of HPV infected diseases. The content of the polypeptides F1 and F3 or a mixture of the two polypeptides is 3-30 mu g in every part of the pharmaceutical composition, and the composition is prepared into multiple conventional dosage forms such as emulsion, ointment preparations and the like and is used for treating easily reoccurring diseases caused by the HPV infection, such as condyloma acuminate, cervical cancer, carcinoma of vulva, carcinoma of penis, anal carcinoma, carcinoma of mouth and the like. The pharmaceutical composition disclosed by the invention has the advantages of short usage course of treatment, small active ingredient amount, exact curative effects, low reoccurrence rate, small side effects, low treatment cost and the like, and brings an excellent therapy pathway to patients.

The invention relates to a traditional Chinese medicine composition for treating verruca acuminata, and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following medicinal raw materials in parts by weight: 1-3 parts of isatisindigotica fort., 1-3 parts of isatisindigotica fortune, 1-3 parts of lithospermumerythrorhizon and 1-3 parts of semen coicis.The preliminary result shows good curative effect when the decoction of the traditional Chinese medicine composition is applied to treat verruca acuminata, and the lesion can be completely eliminatedwithout wound and adverse reaction.

The invention provides a novel polynucleotide gene segment of coded recombinant protein HPV6L1, a vector containing the gene segment, a host cell containing the vector, a protein HPV6L1 pentamer obtained by translating and expressing the gene segment, and an HPV6 infection-resistant condyloma acuminate vaccine consisting of the pentame.

The invention relates to a recombinant human papilloma virus 18L1 protein and its use, and provides a new polynucleotides gene fragment coding the recombinant HPV18L1 protein, a vector containing the gene fragment, a host cell containing the vector, an HPV18L1 protein pentamer expressed by the gene fragment in translation, and an anti-HPV18 infection condyloma acuminatum vaccine composed of the pentamer.

The invention relates to a mutant HPV35 L1 protein (or its variant), its coding sequence and a preparation method thereof. The invention also relates virus-like particles containing the protein. The protein (or its variant) and the virus-like particles are capable of inducing neutralizing antibodies against at least two types of HPV (such as HPV 35 and HPV 16, or HPV 35, HPV 16 and HPV 31), thereby preventing infections of the at least two types of HPV as well as diseases caused by the infections such as cervical cancer and condyloma acuminata. The invention also relates to application of theabove proteins and the virus-like particles to the preparation of a pharmaceutical composition or vaccine. The pharmaceutical composition or vaccine can be used for preventing the infections of the atleast two types of HPV as well as diseases caused by the infections such as cervical cancer and condyloma acuminata.

The invention relates to mutated HPV68L1 protein (or a variant thereof), and a coding sequence and preparation method of the mutated HPV68L1 protein (or the variant thereof), as well as virus-like particles containing the mutated HPV68L1 protein (or the variant thereof). The protein (or the variant thereof) and the virus-like particles can induce neutralizing antibodies which can resist at least two types of HPVs (such as HPV68 and HPV39), so that the protein (or the variant thereof) and the virus-like particles can be used for preventing infection with at least two types of HPVs, and diseasescaused by the infection, such as cervical cancer and condyloma acuminatum. The invention also relates to the purpose of the protein and the virus-like particles for preparation of a medical composition or a vaccine. The medical composition or the vaccine can be used for preventing the infection with at least two types of HPVs, and the diseases caused by the infection, such as the cervical cancerand the condyloma acuminatum.

The invention belongs to the technical field of medicines, and relates to a novel chlorin e4 derivative and pharmaceutically acceptable salts thereof, and preparation methods and application of the novel chlorin e4 derivative and thepharmaceutically acceptable salt thereof. The chlorin e4 derivative comprises a structure shown as a general formula I and an optical isomer contained in the structural general formula I; according to the preparation method, 17-propionyl or 13-formyl in chlorin e4 and amino acid are subjected to peptide formation and / or 3-vinyl etherification. The chlorin e4 derivative and the pharmaceutically acceptable salt thereof can be applied as a photodynamic antitumor drug. Compared with the existing similar photosensitizer talaporfin which is clinically applied, the chlorin e4 derivative disclosed by the invention has the advantages of strong photodynamic antitumor activity, high dark toxicity-light toxicity ratio and the like; the derivative can be used for preparing novel photodynamic antitumor drugs including photodynamic cancer treatment drugs, drugs for photodynamic treatment of benign vascular diseases such as age-related macular degeneration and nevus flammeus and drugs for photodynamic treatment of condyloma acuminata.

The invention relates to a truncated L1 protein of the Human Papillomavirus Type 6, a virus-like particle consisting of the protein, a vaccine comprising said virus-like particle, and the use of the vaccine in the prevention of condyloma acuminatum or HPV infections.

The invention relates to the technical field of traditional Chinese medicine gel, in particular to compound traditional Chinese medicine gel containing podophyllotoxin and a preparation method of thecompound traditional Chinese medicine gel, the preparation process is simple and convenient, the product quality is stable, a solution obtained after traditional Chinese medicine extracts are dissolved is used for swelling carbomer, the dispersion uniformity of traditional Chinese medicine ingredients in the gel is enhanced to a great extent. Ethanol, glycerin and propylene glycol are added duringpreparation of the gel matrix, so that the gel matrix has certain solubility to podophyllotoxin, precipitation of podophyllotoxin is avoided when a podophyllotoxin ethanol solution is dropwise addedto the gel matrix for mixing, and the problem that podophyllotoxin is insoluble in hydrogel is solved. The podophyllotoxin-containing compound traditional Chinese medicine gel prepared by the method disclosed by the invention has the advantages of excellent properties, uniform components and stable gel quality. The gel disclosed by the invention contains podophyllotoxin and traditional Chinese medicine extract, so that the rapid curative effect of podophyllotoxin and the recurrence prevention effect of traditional Chinese medicines can be well combined. The gel can be used for treating condyloma acuminatum or preventing postoperative recurrence, can be used immediately after being applied, is convenient to use, can form a film quickly after being used, and avoids polluting clothes.

Disclosed are a mutated HPV11 L1 protein (or a variant thereof), a sequence encoding the same, a method for preparing the same, and a virus-like particle comprising the same, wherein the protein (or a variant thereof) and the virus-like particle can induce the generation of neutralizing antibodies against at least two HPV types (e.g. HPV11 and HPV6), and therefore can be used to prevent infection by said at least two HPV types, and a disease caused by said infection, such as cervical cancer and condyloma acuminatum. Also disclosed is use of the protein and the virus-like particle in the manufacture of a pharmaceutical composition or a vaccine for preventing infection by said at least two HPV types, and a disease caused by said infection, such as cervical cancer and condyloma acuminatum.

The invention relates to the field of traditional Chinese medicine and pharmacy, and specifically relates to an external ointment for treating various skin warts. The ointment solves the problem that in the prior art, the methods for treating skin warts have the disadvantages of high cost, bad curative effect, unstable effect, and large side effect. The ointment is prepared from the following components: semen pharbitidis, talcum, balloonflower root, pinellia ternate, ligustrum lucidum, stemona, calamine powder, lanolin, and vaseline. The ointment is prepared by the following steps: grinding and sieving traditional Chinese herbals, mixing to obtain traditional Chinese herbal powder; mixing vaseline and lanolin, heating to a temperature of 70 DEG C, adding traditional Chinese herbal powder and calamine powder, evenly stirring, cooling, and adding glacial acetic acid to obtain the external ointment. The external ointment has the functions of clearing heat, removing toxin, cooling blood, removing stasis, dispelling dampness, and dissipating binds. The heat toxin is removed, the blood stasis is eliminated, and the dampness evil is dissipated, so the warts fall down from skin, the collaterals becomes unobstructed, the disease is cured, no scare is left, patients will not feel painful, and the ointment has a good curative effect on various warts caused by infection of papilloma virus, such as common wart, plantar wart, plane warts, verruca acuminata, and the like, and has the advantages of low price and user-friendliness.

The invention discloses a traditional Chinese medicine preparation with an antiviral function. Raw materials, namely, peach seeds, seeds of job's tears, heartleaf houttuynia herbs, cape jasmine, purslane herbs, ginkgo seeds, dark plum fruits, semen cassiae, mulberry leaves, perilla and mint, are matched, so that the preparation has a synergistic effect, and the raw materials cooperate with one another to realize functions of promoting blood circulation, removing blood stasis, regulating immunity and killing viruses. Clinical trials indicate that the traditional Chinese medicine preparation has a very good treatment effect on viruses such as flat warts, condyloma acuminatum and the like and has a very good conditioning effect on various diseases (skin and mucosa low-risk and high-risk problems such as flat warts, common warts, condyloma acuminatum, early-stage cervical cancers) caused by human papilloma viruses as well as hepatitis B virus, various common cold viruses and the like.

The invention discloses a preparation method of a disinfectant for skin. The disinfectant is prepared from hawthorn seed extract, dark plum and chlorhexidine acetate according to a certain proportion,and the disinfectant is mainly used for treating condyloma acuminatum and verruca plana caused by HPV virus infection, and can also be used for fungal infection of onychomycosis and other hands and feet. The disinfectant prepared by the method has the characteristics of exact curative effect, safety, convenience, no toxic or side effect and low price, can take effect within one week, can radically treat verruca plana and condyloma acuminatum within one month, and can quickly relieve the pain of a patient.

The invention discloses a traditional Chinese medicine composition for treating condyloma acuminatum. The traditional Chinese medicine composition is prepared from the following components in parts by weight: 15-22 parts of pangolin, 20-25 parts of kuh-seng, 16-22 parts of alumen exsiccatum, 25-35 parts of purslane, 16-22 parts of rhizome atractylodis, 10-15 parts of Chinese rhubarb, 16-22 parts of curcuma zedoary, 20-25 parts of favus, 10-15 parts of boron sand and 20-25 parts of gallnut. The traditional Chinese medicine composition has the effects of clearing heat and damp-drying, expellingwind and desinsecting, invigorating the circulation of blood and dissipating stasis, treating coagulated cold by purgation and softening and resolving hard mass, and has an obvious effect in the aspect of treating the condyloma acuminatum, fungal infection or cervical erosion. The medicament is safe and convenient for use and has no obvious toxic or side effect, and the recurrence rate of the disease after the medicament is used is extremely low.

At present, the whole world is a lack of clinically high-efficient and safe broad-spectrum antiviral drugs. A composite of total riboside proteosome component that is prepared from plant chickweed or another stellaria plant and extracted by two resin adsorption methods and a hydroalcohol through a hyperfiltration method, has a molecular weight of 1,000 to 100,000 and is in the form of dark brown powder is used as a safer and more high-efficient broad-spectrum antiviral natural drug. The total protein of the total riboside proteosome component takes up 15% to 25% in the chemical construction, and is made up of 17 amino acids, such as asparaginic acid, glutamic acid, serine, histidine, cystine, methionine, isoleucine and the like in proportions; the proportion of sugar comprises ribose, glucose, galactose and arabinose, and total ribonucleotide takes up 5% to 10% and comprises uracil, thymine, thymidine, guanosine, 2-chloro-adenosine. The composite can be used as a drug for treating virus diseases, such as AIDS virus, hepatitis virus, respiratory syncytial viruses like influenza virus, parainfluenza virus, adenovirus, and the like, including highlypathogenic avian influenza virus, and condyloma virus, enterovirus, mumps virus, herpes simplex virus, herpes zoster virus and varicella-zoster virus. Moreover, the composite has no toxicity, and can be made into more than 10 types of medicine preparations, health products and the like, while causing no environmental pollution in the production process.

An external traditional Chinese medicine for treating warts belongs to the traditional Chinese medicine composition, and the invention specifically relates to an external traditional Chinese medicine for treating warts. The traditional Chinese medicine provided by the invention suits the remedy to the case and has good curative effect. The prescription for treating common warts comprises the following traditional Chinese medicines: 8-12 parts of isatis root, 2-4 parts of folium isatidis, 5-8 parts of lithospermum, 4-6 parts of curcuma tuber, 6-10 parts of rhizoma cyperi, 4-6 parts of radix paeoniae rubrathe, 8-10 parts of seed of Job's tears and 1-3 parts of pberetima. The prescription for treating verruca plana comprises the following traditional Chinese medicines: 4-6 parts of patrinia herb, 1-4 parts of isatis root, 6-8 parts of prunella vulgaris, 5-8 parts of purslane, 4-6 parts of curcuma rhizome, 8-10 parts of hedyotis diffusa, and 2-4 parts of dried orange peel. The prescription for treating condyloma acuminatum comprises the following traditional Chinese medicines: 3-7 parts of gentian, 6-8 parts of Polygonum cuspidatum, 2-4 parts of radix paeoniae rubrathe, 1-2 parts of curcuma rhizome, 5-8 parts of lithospermum, 8-12 parts of dandelion, 7-9 parts of citrus chirocarpus and 8-10 parts of unprocessed Rhizoma Pinelliae.

The invention belongs to the technical field of traditional Chinese medicines, and discloses a traditional Chinese medicine composition for treating condyloma acuminatum and a preparation method thereof. Rheum officinale is used for clearing heat, purging fire, cooling blood and detoxifying; camphor is used for treamting mange pruritus and sore and ulcer damp rot; polygonum cuspidatum is used for treating carbuncle swelling and sore toxin; radix sophorae flavescentis is used for treating eczema, eczema and skin itching; fructus cnidii has an anti-pathogenic microorganism effect; cortex dictamni is used for treating damp-heat sore-toxin and eczema; yellow lead draws out poison, promotes tissue regeneration and kills parasites to relieve itching; Chinese gall astringes is used for reducing dampness and relieving sores, and has an inhibition effect on staphylococcus aureus, streptococcus, pneumococcus, typhoid fever, paratyphoid fever, dysentery, anthrax, diphtheria, pseudomonas aeruginosa and other bacilli; fructus kochiae has the effects of inducing diuresis, treating stranguria, clearing heat, promoting diuresis and relieving itching cortex phellodendri has the effects of clearing heat, drying dampness, purging fire, removing toxin and removing bone steaming. The effects of dispersing wind heat and removing blood poison are achieved; the effects of resisting pathogenic microorganisms, clearing away heat and toxic materials, inhibiting bacteria, killing viruses, softening hardness to dissipate stagnation, drawing out poison and promoting tissue regeneration are achieved. The preparation method is simple and convenient to prepare, store and use.

The invention discloses a traditional Chinese medicine composition for treating condyloma acuminatum. The traditional Chinese medicine composition is prepared from the following components in parts by weight: 15-22 parts of pangolin, 20-25 parts of kuh-seng, 16-22 parts of alumen exsiccatum, 25-35 parts of purslane, 16-22 parts of rhizome atractylodis, 10-15 parts of Chinese rhubarb, 16-22 parts of curcuma zedoary, 20-25 parts of favus, 10-15 parts of boron sand and 20-25 parts of gallnut. The traditional Chinese medicine composition has the effects of clearing heat and damp-drying, expellingwind and desinsecting, invigorating the circulation of blood and dissipating stasis, treating coagulated cold by purgation and softening and resolving hard mass, and has an obvious effect in the aspect of treating the condyloma acuminatum, fungal infection or cervical erosion. The medicament is safe and convenient for use and has no obvious toxic or side effect, and the recurrence rate of the disease after the medicament is used is extremely low.

The present invention provides a puccoon extract-puccoon polysaccharide and its application in preparation of medicine for effectively curing pointed condyloma. Said medicine has effective action for killing human papilloma virus, so that it can effectively cure the pointed condyloma due to human papilloma virus. Besides, said invention also provides a method for preparing said puccoon polysaccharide by using Chinese medicinal material puccoon.

The present invention relates to a mutated HPV18 L1 protein (or a variant thereof), a sequence encoding the same, a method for preparing the same, and a virus-like particle comprising the same, wherein the protein (or a variant thereof) and the virus-like particle can induce the generation of neutralizing antibodies against at least two HPV types (for example, HPV18 and HPV45, or HPV18, HPV45 and HPV59), and therefore can be used to prevent infection by said at least two HPV types, and a disease caused by said infection, such as cervical cancer and condyloma acuminatum. The invention further relates to the use of the protein and the virus-like particle in the manufacture of a pharmaceutical composition or a vaccine for preventing infection by said at least two HPV types, and a disease caused by said infection, such as cervical cancer and condyloma acuminatum.

Provided are a mutated HPV51 L1 protein or a variant thereof, a coding sequence thereof, a preparation method therefor, and a virus-like particle containing same, wherein the protein or the variant and the virus-like particle thereof are capable of inducing neutralizing antibodies against at least two types of HPV (for example, HPV51 and HPV69, or HPV51, HPV69 and HPV26). Also provided is the use of the above-mentioned protein and the virus-like particle for preparing a pharmaceutical composition or a vaccine, wherein the pharmaceutical composition or the vaccine can be used to prevent infections of the at least two types of HPV and diseases caused by the infections, such as cervical cancer and condyloma acuminatum.

The invention relates to a mutated HPV66 L1 protein (or a variant thereof), a sequence encoding the same, a method for preparing the same, and a virus-like particle comprising the same, wherein the protein (or a variant thereof) and the virus-like particle can induce the generation of neutralizing antibodies against at least two HPV types (e.g. HPV66 and HPV56, or HPV66, HPV56 and HPV53), and therefore can be used to prevent infection by said at least two HPV types, and a disease caused by said infection, such as cervical cancer and condyloma acuminatum. The invention further relates to the use of the protein and the virus-like particle in the manufacture of a pharmaceutical composition or a vaccine for preventing infection by said at least two HPV types, and a disease caused by said infection, such as cervical cancer and condyloma acuminatum.

The invention discloses a traditional Chinese medicine composition for treating condyloma acuminatum. The traditional Chinese medicine composition is prepared from the following Chinese herbal medicine raw materials in parts by weight: 5-15 parts of herba ephedrae, 5-15 parts of apricot kernels, 5-15 parts of radix glycyrrhizae preparata, 15-30 parts of coix seed, 15-30 parts of radix astragali, 10-15 parts of radix isatidis, 20-30 parts of concha margaritifera, 10-15 parts of spica prunellae and 10-15 parts of oysters. According to the traditional Chinese medicine composition for treating thecondyloma acuminatum, the radix astragali is used as a monarch drug, the coix seed, the spica prunellae and the radix isatidis are used as ministerial drugs, the herba ephedrae, the concha margaritifera and the apricot kernels are used as adjuvant drugs, the radix glycyrrhizae preparata and the oysters are used as conductant drugs, and through the synergistic effect of the raw material components, the effects of clearing heat, removing toxicity, promoting diuresis, reducing phlegm, tonifying qi and spleen and resisting an killing bacteria are achieved, the cure rate is high, and the recurrence rate after use is extremely low; and the product is a pure traditional Chinese medicine product, has no toxic or side effect, is low in price and convenient to carry by patients, and is suitable forpromotion and application.

The invention belongs to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating hemorrhoids and its preparation method and application. 20-40 parts of figs, 20-40 parts of purslane, 20-40 parts of forsythia, 20-40 parts of wild chrysanthemum and 20-40 parts of dandelion; the present invention is used for the treatment of internal hemorrhoids, external hemorrhoids and mixed hemorrhoids. The effective rate reaches more than 80%. It has the characteristics of short treatment cycle, low toxicity, high cure rate, low recurrence rate, and low cost. It also has a good therapeutic effect on anal flaccidity, anal abscess, perianal eczema, and perianal condyloma.