3 results about "Gramine" patented technology

The invention provides a composite antibacterial agent for garden plants and a preparation method thereof, and belongs to the technical field of plant disease control. The composite antibacterial agent comprises trichoderma, a synergistic auxiliary agent, a dispersing agent, a protective agent and a wetting agent, wherein the synergistic auxiliary agent is prepared by mixing sophocarpine, baicalin and arundinine in a mass ratio of (1-3): (2-7): (1-2). The composite antibacterial agent provided by the invention can effectively prevent and treat powdery mildew and leaf spot disease, and the prevention and treatment effects are both greater than 85%.

The application discloses application of arundine and the antibiotic in preparation of a medicine for treating a bacterial infectious disease. The arundine has synergistic activity with a plurality of antibiotics in vivo and in vitro, and the combined use has strong bacteriostatic and bactericidal activity on a plurality of drug-resistant bacteria. The effectiveness in vivo and in vitro, the stability and the safety are systematically evaluated, which is helpful to develop a new type of antibiotic adjuvant candidate for resisting multiple drug-resistant bacteria, and to relieve the problem of the increasingly serious multiple drug-resistant bacteria (MDR).

The present disclosure relates to a gramine-platinum(IV) complex as well as a preparation method therefor and the anti-tumor use thereof. One gramine molecule is introduced to one side of the axial direction of a platinum(IV) coordination center to form a mono-substituted tetravalent platinum complex; or one gramine molecule is introduced to one side of the axial direction of the platinum(IV) coordination center, and one molecule of a -NH-aliphatic chain group or an aliphatic chain group is introduced to the other side so as to form a bi-substituted tetravalent platinum complex. The prepared complex has stronger killing ability on tumor cells, and has obviously improved antiproliferative activity in various cell lines; and in triple-negative breast cancer cells having an extremely high malignant degree, the complex compared with clinical platinum drugs has most remarkable effect improvement. The gramine-platinum(IV) complex of the present disclosure has a simple synthesis process and low cost; said complex greatly improves the curative effect of combined drug therapy; and compared with traditional divalent platinum and similar tetravalent platinum drugs, said complex has the advantages of good curative effect, small side effect and the like.