35 results about "O-Methoxyphenol" patented technology

This invention relates to a method for synthesizing ranolazine drug for treating stenocardia. The method comprises: performing amidation and N-monoalkylation on 2, 6-dimethylaniline to obtain N-(2, 6-xylyl)-2-(1-piperazine) acetamide, and then reacting with 2-(2-methoxyphenoxy) epoxyethane generated from o-methoxyphenol and epoxy chloropropane to obtain anolazine. The reactions include the refinery of 2-chloro-N-(2,6-xylyl)acetamide by cyclohexane and the recrystallization of ranolazine by ethanol/ethyl acetate (2:1), thus can raise the yield.

The invention discloses a preparation technology and a refining method of ranolazine, which are more suitable for industrial production. The method comprises the following concrete steps: using 2, 6-dimethylaniline and methylpyrocatechine as original materials; sequentially carrying out four reaction processes of N-acylation, O-alkylation, N-alkylation and N-alkylation to synthesize ranolazine; and then, recrystallizing to obtain a refined product. The refined product obtained by the method has high purity, and the method also has the advantages of simple operation, low production cost and high yield and is more suitable for industrial production.

The invention discloses a method for preparing catechol from lignin, which comprises the following steps: after mixing alkali lignin and a solution, adding the mixture into a high-pressure reaction kettle, and reacting in an inert gas atmosphere to generate guaiacol; and hydrolyzing the guaiacol to obtain the catechol. The invention overcomes the defect of low selectivity in the prior art, solves the problem that the raw material phenol is derived from non-renewable fossil fuels, and provides a method for preparing catechol from the reactant guaiacol prepared by degrading lignin, which is often used as waste in renewable biomass.

The invention provides a high-activity nickel phosphide as well as a preparation method and application thereof. The preparation method is characterized in that a high-load-capacity Ni/SiO2-TiO2 catalyst adopting an SiO2-TiO2 compound oxide as a catalyst carrier is prepared according to a coprecipitation method; then a high-activity Ni2P/SiO2-TiO2 catalyst is prepared according to a triphenylphosphine liquid phase phosphating method; nickel phosphide is used as the active component. According to the method, the Ni/SiO2-TiO2 catalyst is pre-reduced to form highly-dispersed nano nickel particlesbefore being phosphatized, so that Ni/SiO2-TiO2 is easily phosphatized by PPh3 in the liquid phase under low temperature, and as a result, the highly-dispersed Ni2P particles can be produced. Test results show that the catalyst is high in activity for o-methoxyphenol and high in selectivity to cyclohexane.

The invention provides a high-load metal nickel catalyst as well as a preparation method and application thereof. The preparation method is characterized in that Ni(NO3)2.6H2O is subjected to co-precipitation with TiCl4-ethyl alcohol solution and Na2SiO3.9H2O, and water is removed under low surface tension of n-butyl alcohol, thus the high-load metal nickel catalyst which adopts SiO2-TiO2 compoundoxide as a carrier and metal nickel as an active component is prepared; the compound oxide contains TiO2, so that the L acid content is increased; moreover, B acid is generated, and as a result, themutual action between the carrier and the metal component is improved; the surface area of the catalyst is enlarged; the temperature for reduction is reduced; the reduction performance and the dispersing performance of metal nickel are improved; the quantity of active nickel sites on the surface is obviously increased; the reduction nickel particles on the SiO2-TiO2 carrier can be minimized to be4 nm under high load. Therefore, the prepared catalyst is high in low-temperature deoxidization activity, and is high in activity for o-methoxyphenol and high in selectivity to cyclohexane.

The invention relates to a method for synthesizing a drug, and concretely relates to a method for synthesizing berberrubine from catechol. The method comprises the following steps: carrying out a selective methylation reaction on the raw material catechol and 2-chloromethane to obtain o-methoxyphenol, and carrying out a selective formylation reaction to obtain 2-hydroxy-3-methoxybenzaldehyde; carrying out a methylenation reaction on catechol and 2-chloromethane to obtain piperidine, and carrying out a catalytic addition reaction on the piperidine and 2-chloroethylamine to obtain homopiperonylamine; carrying out a one-pot condensation hydrogenation reaction on the homopiperonylamine and 2-hydroxy-3-methoxybenzaldehyde under the action of a nickel-based catalyst, adding hydrochloric acid tothe obtained reaction product, cooling obtained crystals, and performing filtration to obtain a hydrochloride condensate; and refining the hydrochloride condensate, carrying out a cyclization reactionon the refined hydrochloride condensate and glyoxal under the action of a copper-based catalyst, refining the obtained reaction product, adding hydrochloric acid, performing cooling for crystallization, and filtering and washing obtained crystals to obtain the product berberrubine. The method realizes industrial total synthesis of the berberrubine, and opens up a chemical synthesis method for berberrubine drugs.

The invention relates to methoxy polyaromatic ether ketone resin and a preparation method thereof. The preparation method comprises the following steps: taking aromatic dihalide, such as 4,4'-difluorobenzophenone or 4,4'-dichlorophenone and 4,4'-dichlorodiphenylsulfone, and o-methoxyphenol as raw materials, and performing nucleophilic substitution reaction to prepare a methoxyaryl ether monomer; and then performing electrophilic substitution polycondensation reaction on the methoxyaryl ether monomer and acryl chloride such as paraphthaloyl chloride or m-phthaloyl chloride to prepare a series of resin with methoxy polyaromatic ether ketone. The resin has high heat resistance, high dissolubility, high film-forming property and excellent mechanical properties, and the methoxy group can be further functionalized.

The invention discloses a sheep manure wrapping technology. The sheep manure wrapping technology comprise the following steps of step 1, adding auxiliary materials into fresh sheep manure, and adjusting the content of dry mater in the mixture to 30 to 35%; step 2, crushing the mixture, adding 6 to 10wt% of special additive, and radiating for 20 to 30min by ultraviolet ray with intensity of 160 to200muW/cm<2>; step 3, mixing with 10 to 15wt% of microorganism fermenting agent, pressing, and packaging with a film, wherein the pressing density is 799kg/m3>; step 4, fermenting and granulating at the temperature of 30 to 38 DEG C, wherein the special additive comprises the following components in parts by weight: 15 to 23 parts of humic acid, 30 to 40 parts of molasses, 8 to 12 parts of methylfumarate, 10 to 18 parts of calcium peroxide, 0.5 to 2 parts of methoxy-5-nitrophenol sodium salt, and 4 to 11 parts of polyaspartic acid. The sheep manure wrapping technology has the advantages thatthe pollution by impurity bacteria is effectively avoided, the damaged cambia cells of plant are recovered, the conversion rate of sheep manure is improved, and the nutrients are more thoroughly released.

The invention discloses a liquid synergistic fertilizer. The liquid synergistic fertilizer is prepared from the following raw materials in parts by mass: 1-20 parts of dinitrophenol, 2-20 parts of alpha-naphthylacetic acid, 3-15 parts of indoleacetic acid, 5-30 parts of indolebutyric acid, 10-30 parts of o-nitrophenol, 5-20 parts of nitrophenol, 15-45 parts of nitro-o-methoxyphenol, 20-30 parts ofo-methoxyphenol, 10-45 parts of polyoxyethylene ether and 15-35 parts of a mixed enzyme. According to the synergistic fertilizer disclosed by the invention, with the addition of the mixed enzyme, theutilization rate of the chemical fertilizer is increased, the using amount of the chemical fertilizer is reduced, the yield increasing effect is obvious, meanwhile, the pollution to the environment is reduced, and thus the purposes of increasing the yield, enhancing the efficiency, protecting the environment and reducing the cost are achieved.

The invention relates to a crop growth promoting and anti-disease agent with a plurality of functions, and a manufacture and use method thereof. The agent has the following raw material formulas: 2, 4-dinitrophenol (Na) a-naphthylacetic acid (Na), indoleacetic acid (Na), o-nitrophenol (Na), p-nitrophenol (Na), 5-nitroguiacolate (Na), guaiacol (Na), N, N-diethylaminoethanol alkyl caproate, brilliant blue and a filler (which comprises methanol, carbamide, ammonium hydrogen carbonate, ammonium sulphate, ammonium chloride, lemery, potassium chloride, monopotassium phosphate, calcium-magnesia phosphate fertilizer, ordinary superphosphate, organic fertilizer and various composts, and green copperas, zinc sulfate, manganous sulfate, borax, boric acid, bluestone and water). The crop growth promoting and anti-disease agent with a plurality of functions is made by compounding and has the use method that the crop growth promoting and anti-disease agent is evenly sprayed on crops and farms after being diluted with the water which is 1000 to 5000 times the quantity of the crop growth promoting and anti-disease agent, and the dosage of the growth promoting and anti-disease agent per mu is 1 to 1000g.

The invention discloses organic liquid fertilizer. The organic liquid fertilizer is prepared from the following raw materials in parts by mass: 20-40 parts of bone serous fluid, 10-15 parts of bean pulp, 2-8 parts of calcium oxide, 3-6 parts of bacillus subtilis, 2-5 parts of penicillium, 2-6 parts of chloronema, 10-30 parts of amino acid, 5-20 parts of indolebutyric acid, 10-30 parts of o-nitrophenol, 5-10 parts of nitrophenol, 15-25 parts of methoxy-5-nitrophenol, 20-30 parts of o-methoxyphenol, 5-10 parts of polyoxyethylene ether and 30-60 parts of water. The organic liquid fertilizer is added with indolebutyric acid and amino acid, so that a fertilizer usage rate is increased, and therefore, the organic liquid fertilizer has the advantages of being resistant to salt and alkaline, resistant to bacteria, efficient, and the like, reduces pollution on environment, and achieves the purposes of increasing the yield, improving efficiency, being environmentally friendly, and reducing the cost.

The invention provides an artificial supplementary pollination composition. The composition comprises pollen, a component I and a component II, the pollen accounts for 0.05%-0.1% of a pollination spray composition in percentage by mass, substances in the component I comprise, by mass percent in the pollination spray composition, 0.05%-0.10% of phethalanilic acid, 0.01%-0.05% of calcium nitrate, 0.0005%-0.0007% of 2-methoxy-5-nitrophenol sodium salt, 0.005%-0.01% of water-soluble gum acacia powder, 0.5%-1.0% of cane sugar, 0.0020%-0.0021% of sodium para-nitrophenolate, 0.01%-0.05% of boric acid, 0.01%-0.02% of sodium carboxymethylcellulose, 0.0012%-0.0014% of sodium 2-nitrophenolate, and 10%-20% of water. The component II is a water soluble colorant solution. The composition prepared by mixing the pollen, the component I and the component II has the advantages of accessible raw materials and lower cost, can implement commercialization, and can effectively enhance the pollen activity, promote the pollination and fertilization actions and enhance the fruit yield.

The invention belongs to the field of organic synthesis, and particularly relates to a preparation method of urapidil intermediate 1-(2-methoxyphenyl) piperazine and salt thereof. According to the invention, o-methoxyphenol is used as a starting material to prepare the urapidil intermediate 1-(2-methoxyphenyl) piperazine by using a brand-new synthesis route, and methylsulfonyl chloride is adopted to activate hydroxyl on o-methoxyphenol, so that the condensation reaction condition of o-methoxyphenol and imino on piperazine is mild; and the intermediate product does not need to be separated in the intermediate process of the sulfonylation reaction and the condensation reaction, and the operation is simple and convenient. The condensation reaction adopts a mode of adding o-methoxyphenyl methanesulfonate into piperazine, so that two imino groups on piperazine are prevented from being subjected to condensation reaction at the same time, the selectivity of a target product is ensured, excessive impurities are prevented from being introduced into a system, and the purity of the product is improved. In terms of o-methoxyphenol, the total yield of the urapidil intermediate 1-(2-methoxyphenyl) piperazine prepared by the preparation method disclosed by the invention can reach 88% or above. Meanwhile, the preparation method is obvious in cost advantage and suitable for industrial production.

The present invention relates to a growth promoting fertilizer and a preparation process thereof, wherein 0.01-1.5% of 2,4-dinitrophenol, 0.01-1.5% of a- naphthalene acetic acid, 0.01-1.5% of indole acetic acid, 0.01-1.5% of o-nitrophenol, 0.01-1.5% of p-nitrophenol, 0.01-2% of 5-nitro guaiacol, 0.01-2% of guaiacol, 2-4% of methanol, 0.01-2% of N,N-diethylamino ethanol hexanoate, 0.01-3% of citric acid, 0.01-0.5% of brilliant blue, and 85-97% of a compound fertilizer are completely mixed, and processing granulation is performed according to a compound fertilizer manufacturing method. According to the present invention, the growth promoting fertilizer has characteristics of fertilizer utilization rate improving, fertilizer consumption reducing, significant yield increase, rapid effect providing, environmental pollution reducing, crop quality improving, yield increase, effect increase, and cost reduction.