4 results about "O-Methoxyphenol" patented technology

The invention relates to a green synthesis method of 2, 4-dicumyl phenol. The invention belongs to the field of synthesis of medical intermediates. The invention aims to solve the technical problems that the raw materials are non-renewable, thermal runaway is easily caused by high-temperature reaction, the energy consumption is high and the content of 3-substituted by-products is relatively high in the existing synthesis method of 2, 4-dicumyl phenol. The method comprises the following steps: adding vanillin into an electrolyte, and carrying out electrochemical deoxidation in a proton exchange membrane electrolytic cell by taking a titanium-based DSA electrode as an anode to obtain o-methoxyphenol; according to the method, o-methoxyphenol and cumene are subjected to a free radical coupling reaction in a flowing electrochemical reactor in the presence of a homogeneous electron transfer catalyst by taking a titanium-based DSA electrode as an anode, and high-purity 2, 4-dicumyl phenol is obtained through extraction and distillation after the reaction is finished. According to the method, the raw materials are 100% renewable, strong acid and high temperature are avoided, hazardous waste emission is avoided, few trisubstituted by-products are generated, and industrial production can be carried out.

The invention belongs to the technical field of medicine synthesis, and particularly relates to a novel preparation method of ranolazine. The preparation method comprises the following steps: carrying out unilateral protection on piperazine by adopting Fmoc-Cl to prepare N-Fmoc-piperazine; n-Fmoc-piperazine reacts with 2-chloro-N-(2, 6-dimethylphenyl) acetamide to prepare N-Fmoc-N-(2, 6-dimethylphenyl)-1-piperazine acetamide, then the N-Fmoc-N-(2, 6-dimethylphenyl)-1-piperazine acetamide is subjected to deprotection under the alkaline condition, and the N-Fmoc-N-(2, 6-dimethylphenyl)-1-piperazine acetamide reacts with 1-(2-methoxyphenoxy)-2, 3-epoxypropane to prepare a ranolazine crude product; and recrystallizing the crude product to obtain a finished product. Wherein the 1-(2-methoxyphenoxy)-2, 3-epoxypropane reaction liquid is prepared by taking o-methoxyphenol, epichlorohydrin and alkali as raw materials, and carrying out reaction in water, so as to obtain the 1-(2-methoxyphenoxy)-2, 3-epoxypropane reaction liquid. The method can effectively avoid the generation of piperazine disubstitutes, greatly reduces the use amount of piperazine, and has the characteristics of short production period, low cost and suitability for industrial production.

The present application relates to the chemical technology field, specifically to a method for synthesizing vanillin and ortho-vanillin by one-step method, which uses o-methoxyphenol as starting material, and carries out one-step reaction with formaldehyde under the action of composite catalyst, and then separates vanillin and ortho-vanillin by post-treatment of the reaction solution. By using the composite catalyst with specific composition, the present application realizes high-selectivity formylation of formaldehyde at the ortho position of the hydroxyl group of o-methoxyphenol, increases the generation proportion of ortho-vanillin from the source, avoids the use of toxic reagent, and has mild reaction conditions. By using the difference in solubility of specific mixed solvent system and adjusting the temperature, the present application can efficiently separate vanillin and ortho-vanillin, and solves the separation problem caused by the similar properties of isomers in the prior art. The overall process is simple and efficient, and the yield and product purity are significantly improved, which has excellent industrial application prospect.

A lanthanum phosphite supported zirconia catalyst, its preparation method and application relate to the field of catalysts. The preparation method comprises the following steps: S1: adding a phosphite compound into an organic solvent, stirring to obtain a mixed solution I; S2: adding an aqueous lanthanum salt solution into the mixed solution I, and then heating to boiling to obtain a mixed solution II; S3: adding an aqueous zirconium salt solution and an aqueous urea solution into the mixed solution II, and then heating to 80°C - 100°C to obtain a mixed solution III; S4: cooling the mixed solution III, and then successively performing suction filtration, washing with water, pressure filtration, drying, and calcination to obtain the lanthanum phosphite supported zirconia catalyst. The lanthanum phosphite supported zirconia catalyst of the present invention can catalyze the reaction of glyoxylate and o-methoxyphenol to synthesize 2-hydroxy-2-(4-hydroxy-3-methoxyphenyl) acetate.