The utility model provides a storage device with a self-destruction function, which comprises an upper shell, a slide knob module, a storage module and a lower shell, an opening is arranged on the upper part of the upper shell in a penetrating manner, a partition plate piece contained in the slide knob module is arranged on the lower part of the upper shell, the partition plate piece is provided with a flexible part, and the flexible part is provided with a self-destruction function. The partition plate piece is provided with an opening, the sliding button piece is arranged above the partition plate piece in a sliding mode, the sliding button piece protrudes out of the opening and is arranged in the opening in a sliding mode, the storage module comprises a circuit board, a storage element, a control element and a switch, the lower shell is arranged below the storage module, the storage module is wrapped by the upper shell and the lower shell, and the control element is arranged on the upper shell. The sliding knob piece slides and abuts against the flexible part, so that the flexible part presses the switch, and the control element breaks down the storage element through a boost conversion unit.