177results about "Stopper pretreatment" patented technology

A method of manufacture for a drug cartridge assembly. The method includes providing a drug cartridge, providing a nozzle sub-assembly, and sterilizing the drug cartridge and nozzle sub-assembly. The method further includes assembling the drug cartridge and nozzle sub-assembly together in a configuration that enables ejection of liquid out of the drug cartridge through the nozzle sub-assembly. The method further includes filling the drug cartridge with a liquid, such as an injectable drug. The method may include separate sterilization of the drug cartridge and nozzle sub-assembly, using different sterilization processes. Portions of the method may be performed prior to sterilization within a first cleanroom, with subsequent steps being performed in a second cleanroom having a substantially lower particulate-per-volume rating than the first cleanroom.

A system for processing a simplified plastic container (C) that is to be filled with a hot product includes the step of blow-molding parison to form a container body, where the container body has a neck, a base, a side surface relatively free of structural geometry that surrounds an interior of the container body and, prior to being filled with the hot product, a projection (12) extending from the container body. After the container body is filled with a hot product in a production line, the neck of the filled container body is capped with a cap and then, the container body is cooled. During the cooling operation, the hot product is contracted so that the projection extending from the container can be pushed (P) into the container body like a traditional push-up so that the resultant, filled and cooled container body is relatively free of structural geometry.

The present invention discloses a method and apparatus for sterilizing containers with gas-phase hydrogen peroxide and heat on a linear form, fill and seal packaging machine. A partially formed container is subjected to multiple applications of gaseous hydrogen peroxide and hot air within a sterilization tunnel. The sterilization tunnel is maintained at a temperature greater than the condensation temperature of hydrogen peroxide. The present invention sterilizes the container allowing for filling of the container with a high acid product such as orange juice for ambient distribution. The container may be any number of possibilities such as TETRA REX TM gable top cartons, plastic bottles, and the like. The invention allows for the efficacious use of hydrogen peroxide gas having a concentration of up to 53%.

A stopper and container body are molded in the same molding machine. An assembly device, such as a pick and place robot, transfers the stopper from one mold cavity into the opening in the container body located within another mold cavity, or vice versa, to assemble the stopper and container body. Then, the assembled container body and stopper are removed from the molding machine and transported to a needle filling and laser resealing station for filling and laser resealing. A laminar flow source directs a substantially laminar flow of air or sterile gas over the mold surfaces, stoppers and container bodies, and assembly device, to prevent contamination during assembly.

A stopper and container body are molded in the same molding machine. An assembly device, such as a pick and place robot, transfers the stopper from one mold cavity into the opening in the container body located within another mold cavity, or vice versa, to assemble the stopper and container body. Then, the assembled container body and stopper are removed from the molding machine and transported to a needle filling and laser resealing station for filling and laser resealing. A laminar flow source directs a substantially laminar flow of air or sterile gas over the mold surfaces, stoppers and container bodies, and assembly device, to prevent contamination during assembly.

An inventive method, system and apparatus are provided for syringe handling, and more particularly, for syringe labeling, filling and capping operations. To facilitate syringe handling, an inventive apparatus includes a plurality of syringe bodies interconnected in a predetermined orientation by a belt. Such belt may be of pliable construction and may define a predetermined spacing in between adjacent ones of the syringe bodies, such predetermined spacing corresponding with a distance between holders provided in a handling apparatus. The syringe handling apparatus may provide for the placement of contents-related information on belt segments between adjacent syringe bodies and for separating the belt segments, wherein a flap is left interconnected to each syringe body. The syringe handling apparatus may alternatively or also provide for automated filling of the syringe bodies wherein cap removal, filling and cap replacement operations are completed free from manual handling.

A method for sterilizing at least partly formed packages with electron beam irradiation in a packaging machine involves sterilizing each of at least two at least partially separate areas of the package by way of a respective electron beam sterilizing device, with each of the sterilizing devices being adapted to characteristics of each respective one of the two areas, and also performing a respective relative movement between the package and each of the electron beam sterilizing devices, which movements are adapted for the sterilization of each respective one of the two areas with the sterilizing devices.

For closing bottles with sterile caps, the caps are placed in a non-sterile environment in a vertical arrangement and are supplied vertically to a first sterile area. The interior of the caps is arranged to be accessible horizontally. The caps are sterilized in the first sterile area and transferred to a second sterile area where the caps are placed onto bottles. Subsequently, the bottle is closed with the cap. The machine for sterile closing of bottles with caps has a sterilization device with an individualization device for picking up caps and a vertical transport path feeding the caps to the sterilization chamber. A placing device receives the caps from the sterilization device and places the caps onto bottles. A closing device closes the bottles with the cap placed thereon. The sterilization device, the placing device, and the closing device operate as synchronized modules of a linear machine.

The invention refers to a device (1) and method for sterilizing partly formed packages (6) in a packaging machine. The device (1) comprises an inner chamber (2) and an outer chamber (3), the inner chamber (2) being provided with a sterilization unit (5). Further, it comprises a carrier unit (10), comprising a separating member (11) and a package carrying member (12), which is being adapted to rotate between a first position in which the package carrying member (12) is located in the outer chamber (3), and in which the separating member (11) separates the inner chamber (2) from the outer chamber (3), and a second position in which the carrier unit (10) has rotated a package (6) into the inner chamber (2) and in which the separating member (11) separates the inner chamber (2) from the outer chamber (3).

A device for the sterile filling of liquids in bottles, having a sterilizer which is used to sterilize the bottles with H2O2, a filling element which is used to fill the bottles, a closing element which is used to apply a closing element as a closing lid, and structure to adjust the temperature of the bottle whereby condensation of the H2O2 on the surface of the bottle is prevented. Also, a method for sterile filling of liquids in bottles comprising the steps of the bottles are sterilized with H2O2, then filled and closed. During sterilization, the bottles have such a temperature that condensation of the H2O2 is prevented on the surface of the bottles.

A method and apparatus for treating packaging and an installation for filling and closing packaging, including an apparatus for treating packaging. The abstract of the disclosure is submitted herewith as required by 37 C.F.R. §1.72(b). As stated in 37 C.F.R. §1.72(b): A brief abstract of the technical disclosure in the specification must commence on a separate sheet, preferably following the claims, under the heading “Abstract of the Disclosure.” The purpose of the abstract is to enable the Patent and Trademark Office and the public generally to determine quickly from a cursory inspection the nature and gist of the technical disclosure. The abstract shall not be used for interpreting the scope of the claims. Therefore, any statements made relating to the abstract are not intended to limit the claims in any manner and should not be interpreted as limiting the claims in any manner.

This disclosure is directed towards a method and apparatus provided for improved sterile labeling on medications, solutions and medical supplies. The apparatus includes a sterile label, including associated corresponding medical product information. The sterile label is contained inside a sterile cavity housing which is formed from a first and second sheet of flexible plastic or other material. The flexible plastic material is bound together along its peripheral edges by an adhesive or heat sealing process. In this form, the flexible plastic or other material creates a package which may be peeled apart, enabling the label to be delivered or flipped to a sterile field while maintaining sterility. The label may contain on it many types of information corresponding to a medication. Furthermore, information can be added by a user. The disclosure makes the medication labeling system more accurate, safe and legible.

The invention relates to a device and a method for producing containers, such as e.g. bottles, in which different types of bottles are produced. Alternative treatment methods are used depending on the type of bottle to be produced. For example, a cooling treatment is carried out when producing bottles for carbonated beverages and a sterilisation treatment is carried out when producing bottles for non-carbonated beverages.

A method of handling, filling and sealing prefabricated packaging containers that are provided with a closure device is disclosed. The packaging containers are transported in the closed state to a processing plant in which the closure device is opened, the packaging container and closure device are sterilized, and thereafter the packaging container is filled with the desired liquid contents. The same closure device that was removed from the packaging container is then reapplied to seal the container.

A vertical pouch forming, filling and sealing machine and method for making pouches and filling same with a liquid content in the range of about 5 to 20 liters, is described. As a pouch is being filled with a liquid it descends into a support cage to restrain the pouch from ballooning out and prevents the weight of the liquid in the filled pouch from tensioning the film in the hot horizontal seal zone of the horizontal sealer. The support cage compensates for loss of surface tension of the film in the hot horizontal seal zone during the horizontal sealing cycle. The cage also has a gate section to discharge the filled pouch by gravity after the horizontal sealing cycle.

A beverage bottling plant for filling bottles with a liquid beverage, having a filling element of a filling machine with a rotary construction for filling bottles or similar containers with a liquid has, in a filling element housing, a liquid duct for the controlled dispensing of a liquid at a dispensing opening. The dispensing opening is located in a recess into which the respective container extends with its container mouth during the filling, and into which at least one additional duct of the filling element empties. During a cleaning or rinsing phase, the recess can be closed by a plate-shaped closing element.

The present invention relates to a method for manufacturing glass containers for pharmaceutical use. This method allows obtaining containers with a low degree of alkalinity. In some preferred embodiments the process allows the manufacture of sterile containers and substantially free of particles ready to be used by the pharmaceutical industry.

A structural forming assembly comprises wall molding panels for forming laterally spaced, opposed molding surfaces that define a wall mold cavity for forming a wall structure. The wall panels are vertically disposed and laterally spaced to provide the molding surfaces along opposed sides of the wall mold cavity. Reinforcement rod suspending grid elements attached to the opposed wall forming panels are for freely positioning and retaining horizontally and freely disposed reinforcement rods at a preselected horizontal location spaced inwardly from each opposed molding surface within the mold cavity, and at spaced preselected vertical locations between the molding surfaces. The rod suspending elements are effective to retain reinforcement rods in place at the preselected horizontal and vertical locations while the hardenable material is being poured into an upwardly directed top mold opening and allowed to harden within the wall mold cavity. The invention includes a fixed construction that comprises a monolithic building structure including a floor slab having a top surface, and an upper building portion having a ceiling slab and a wall structure, which extends along the floor top surface in a room layout of a building in accord with a preselected floor plan.

A sterilization system for use in association with a filler device configured for filling at least one of rigid and flexible containers comprising a sterilization chamber and a sterilant supply assembly. The sterilization chamber includes a housing, an inlet into the housing, an outlet from the housing and a product retainer assembly. These components define a cavity within which to position a portion of a fitment. The sterilant supply assembly comprises a steam generating system having a steam supply conduit extending therefrom and a joint mixing conduit coupled with the inlet into the housing of the sterilization chamber, a hydrogen peroxide storing system and a member for metering liquid phase hydrogen peroxide from the hydrogen peroxide storing system into the steam supply conduit for mixing therewith, and, in turn, introduction thereof into the cavity of the sterilization chamber.

A treatment device handles and treats bottle or container caps, which treatment device may be used in a capping machine in a beverage bottle or container filling plant. The treatment device transports the caps on carrier rings and transfer chutes inside a housing, which has a flow of treatment gas traveling therethrough to treat the caps.

A unit for sterilizing a web (2) of packaging material on a machine (1) for packaging pourable food products, the unit having a bath (7) containing a sterilizing agent, in which the web (2) is fed continuously; a process chamber (8) connected to an outlet (12) of the bath (7), and which houses wringing rollers (18) interacting with the web (2), and a nozzle (22) for directing a stream of air on to the web (2) and removing residual sterilizing agent from the web; an aseptic chamber (25) communicating with the process chamber (8) via an opening (27) for passage of the web (2), and in which the web (2) is folded and sealed longitudinally to form a tube (29) which is filled continuously with the product for packaging; and an air processing circuit (24) for controlling process conditions, and having a conduit (56) for feeding a first stream of sterile air into the aseptic chamber (25), a conduit (54) for feeding a second stream of sterile air to the nozzle (22) and housing a heater (69) for controlling the temperature of the air supplied to the nozzle (22), and a distributor for regulating the two streams of air.

A method and arrangement for treating bags to be filled with a product prior to filling the bags with a product. The abstract of the disclosure is submitted herewith as required by 37 C.F.R. §1.72(b). As stated in 37 C.F.R. §1.72(b): A brief abstract of the technical disclosure in the specification must commence on a separate sheet, preferably following the claims, under the heading “Abstract of the Disclosure.” The purpose of the abstract is to enable the Patent and Trademark Office and the public generally to determine quickly from a cursory inspection the nature and gist of the technical disclosure. The abstract shall not be used for interpreting the scope of the claims. Therefore, any statements made relating to the abstract are not intended to limit the claims in any manner and should not be interpreted as limiting the claims in any manner.

A beverage bottle or container filling plant having a beverage bottle or container treatment arrangement and a method of operating a beverage bottle or container filling plant. The abstract of the disclosure is submitted herewith as required by 37 C.F.R. §1.72(b). As stated in 37 C.F.R. §1.72(b): A brief abstract of the technical disclosure in the specification must commence on a separate sheet, preferably following the claims, under the heading “Abstract of the Disclosure.” The purpose of the abstract is to enable the Patent and Trademark Office and the public generally to determine quickly from a cursory inspection the nature and gist of the technical disclosure. The abstract shall not be used for interpreting the scope of the claims. Therefore, any statements made relating to the abstract are not intended to limit the claims in any manner and should not be interpreted as limiting the claims in any manner.

A vertical pouch forming, filling and sealing machine and method for making pouches and filling same with a liquid content in the range of about 5 to 20 liters, is described. As a pouch is being filled with a liquid it descends into a support cage to restrain the pouch from ballooning out and prevents the weight of the liquid in the filled pouch from tensioning the film in the hot horizontal seal zone of the horizontal sealer. The support cage compensates for loss of surface tension of the film in the hot horizontal seal zone during the horizontal sealing cycle. The cage also has a gate section to discharge the filled pouch by gravity after the horizontal sealing cycle.

An object of this invention is to provide a drug solution container package, which can restrain degradation of a drug solution, proliferation of microbes, etc. accompanying the transmission of oxygen in a high degree while maintaining characteristics required of plastic drug solution containers such as heat resistance, impact resistance, pliability, transparency, and resistance against elution of plastic forming material, and to provide a method for manufacturing the drug solution container package. In the present invention, to achieve the above object, a drug solution is contained and sealed in a plastic drug solution container having an oxygen gas transmission rate (25° C., 60% RH) of not less than 200 cm3 / m2·24h·atm within twelve hours after being subject to steam sterilization or hot water sterilization, and having an oxygen gas transmission rate (25° C., 60% RH) of not more than 100 cm3 / m2·24 h·atm when the oxygen gas transmission rate is in a steady state, and thereafter the plastic drug solution container is steam sterilized or hot water sterilized and then are contained and sealed along with an oxygen scavenger in an outer pouch having an oxygen barrier property.