The present invention belongs to the field of slow-release fertilizers, and specifically discloses a melon high-efficiency slow-release fertilizer with degerming insecticidal effects, the melon high-efficiency slow-release fertilizer with degerming insecticidal effects is characterized by comprising the following components in parts by weight: garlic polysaccharide sulfide derivative, attapulgite, polyvinyl alcohol, a crosslinking agent, polyglutamate hydrogel, mesoporous silica nanoparticles, salicylic acid, toosendanin, pyrethrum, tea polyphenols, composite microbial agents, sodium selenite, compound sodium nitrophenolate, viscous konjac flour, residue of furfural, brown sugar residue, and amino acids and the like. The garlic polysaccharide sulfide derivative and the attapulgite are used as basic coating materials, the micron size composite hydrogel prepared from the polyglutamate hydrogel and different sizes of mesoporous silica nanoparticle matters are added into the coating materials, the pore size of the coating materials are enriched, the dynamic slow-release performance and nutrient use efficiency of the fertilizer are improved, the fertilizer efficiency regulation property is ensured, the melon high-efficiency slow-release fertilizer promotes the melon to absorb and utilize different nutrients, and promotes the efficient cultivation.