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This invention relates to an early-strength agent for hypersulfate cement concrete and its application, belonging to the field of building materials. The early-strength component of the hypersulfate cement comprises, by weight, the following components: 70-80 parts C-S-H / PCE, 15-25 parts sodium hydroxide or sodium carbonate, 5-10 parts sodium lactate, and 10-20 parts lithium carbonate. This invention solves the problem of long setting time of hypersulfate cement and slow early strength development of the prepared concrete, and plays a positive role in promoting the application of hypersulfate cement.

The invention discloses application of LRP1 in preparation of osteoarthritis medicines, and belongs to the technical field of biological medicines. The m6A methylase can regulate the immune homeostasis of macrophages and regulate chondrogenic differentiation of bone marrow mesenchymal stem cells through LRP1 mediated lipid metabolism reprogramming, so that repair and regeneration of articular cartilage are promoted, and a potential new immune metabolism dual regulation strategy is provided for treatment of osteoarthritis patients.