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Freeze drying powder and injection preparation in use for invigorating pulse-beat, and preparation method

A freeze-dried powder injection and injection technology, which is applied in the field of plant materials, can solve the problems affecting the purity of injections and the therapeutic effect of drugs, and achieve the effects of improving the deformability of red blood cells, increasing cerebral blood flow, and reducing the scope of myocardial infarction

Active Publication Date: 2008-01-02
西安万隆制药股份有限公司
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  • Abstract
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  • Application Information

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Problems solved by technology

[0003] The traditional preparation method of traditional Chinese medicine injection is to prepare the raw materials used by decoction and alcohol precipitation. Many raw materials are boiled together, and their active ingredients are easy to react, which affects the purity of the injection and the treatment of the drug. Effect

Method used

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  • Freeze drying powder and injection preparation in use for invigorating pulse-beat, and preparation method
  • Freeze drying powder and injection preparation in use for invigorating pulse-beat, and preparation method
  • Freeze drying powder and injection preparation in use for invigorating pulse-beat, and preparation method

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Embodiment 1

[0020] Taking the production of 100 (1.4g / support) of pharmaceutical injections of the present invention as an example, the used bulk drug and auxiliary materials and their weight ratios are:

[0021] Danshen 333.3g

[0022] Chuanxiong 333.3g

[0023] Pueraria 333.3g

[0024] Mannitol 90g

[0025] Sodium bisulfite 2g.

[0026] Its preparation method is as follows:

[0027] 1. Prepare 333.3 g of Danshen medicinal material, crush them into coarse particles, add 10 times the amount of sodium hydroxide solution with a concentration of 4.3% and decoct three times for 1.5 hours each time, combine the decoction liquid, and concentrate under reduced pressure to 1 : 1.5 (relative density 1.10-1.15, 50-60°C), adjust the pH to 4.0, add ethanol to make the alcohol concentration reach 65%, stir well, let it stand overnight, filter, recover the ethanol from the filtrate until it has no alcohol smell, add water for injection Adjust to 1:1; adjust pH 11-12 with calcium hydroxide solution...

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Abstract

A freeze-dried powder injection ''Tongmai'' for treating coronary heart disease, angina pectoris and cerebral infarction is prepared proportionally from red sage root, Chuan-xiong rhizome and pueraria root through respectively decocting, vacuum concentrating and depositing in alcohol to obtain their extracts, mixing, adding sodium hydrogen sulfite and manna and conventionally preparing injection.

Description

technical field [0001] The invention belongs to the technical field of medical preparations containing raw materials or their reaction products with unknown structures, and specifically relates to materials derived from plants. Background technique [0002] Currently, there are Guanmaitong Tablets, Kangerxin Capsules, and Naoxintong Capsules, which are clinically used to treat coronary heart disease, angina pectoris and cerebral infarction. Some patients have to take the medicine for several months, and even half a year after taking the medicine, they feel the effect, which causes a great financial burden on the patient and delays the treatment of the disease. In the form of injection, the drug can directly enter the blood circulation, and its bioavailability can be significantly improved compared with oral administration, so that the effect is rapid and reliable, and it is more conducive to the treatment of emergencies such as coronary heart disease, angina pectoris and cer...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/537A61K36/48A61K36/236A61K47/10A61K47/04A61K9/19A61P9/10
Inventor 陈秋林郑方晔刘护鱼
Owner 西安万隆制药股份有限公司
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