Preventive and/or therapeutic agent for viral infection

A virus infection and therapeutic agent technology, applied in the therapeutic agent, teprenone as a preventive field, can solve the problems of unrealistic clinical application, HSP induction method has not yet been established, and achieve the effect of preventing viral infection and treating viral infection

Inactive Publication Date: 2008-01-09
EISIA R&D MANAGEMENT CO LTD +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] However, the HSP induction method requires heat shock, sodium arsenite, heavy metals and other environmental stressors, or pathological stressors such as ischemia, so it is not practical in clinical application, and HSPs that are safe for living organisms have not yet been established. Induction method

Method used

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  • Preventive and/or therapeutic agent for viral infection
  • Preventive and/or therapeutic agent for viral infection
  • Preventive and/or therapeutic agent for viral infection

Examples

Experimental program
Comparison scheme
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Embodiment Construction

[0044] The present invention proposes for the first time that administration of GGA has the effect of preventing and treating influenza virus infection. Hereinafter, while explaining the experiments performed in the present invention, preferred embodiments of the present invention will be described in detail.

[0045] The GGA used in the present invention is commonly called teprenone, and is widely used as a medicine for treating gastric ulcer and gastritis. It can be purchased as reagents and industrial raw materials, and can be synthesized by well-known synthetic methods. The chemical name of GGA is 6,10,14,18-tetramethyl-5,9,13,17-nonadecatetraen-2-one, and its structural formula is shown below.

[0046]

[0047]There are 4 double bonds in the structure of GGA, and there are a total of 8 geometric isomers. The present invention is not particularly limited, and it can be any isomer, or two or more isomers. mixture. Among them, preferred compounds include (5E, 9E, 13E)-6,10,14,...

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PUM

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Abstract

Provided is a novel preventive and / or therapeutic agent against a virus, disclosed is a preventive and / or therapeutic agent against a viral infection containing geranyl-geranyl acetone as an active ingredient. Also, disclosed are inducers for increasing the activity of an anitiviral factor and for protein kinase containing geranyl-geranyl acetone as an active ingredient. Moreover, a method for preventing and / or treating a viral infection which contains administering a patient a effective amount of an agent containing geranyl-geranyl acetone as an active ingredient.

Description

Technical field [0001] The present invention relates to a new use of teprenone (geranylgeranylacetone) as a preventive and therapeutic agent, and more specifically, to a preventive and therapeutic agent for viral infections containing teprenone as an active ingredient. Background technique [0002] Viruses are the cause of various diseases. For example, influenza A virus infection causes group infections or pandemics worldwide. It is one of the viruses that often causes severe symptoms in young children, the elderly, heart and lung diseases or immunodeficiency patients (see Non Patent documents 1-3). [0003] In recent years, although various treatment methods are constantly improving, no effective treatment method for the virus has yet been found. At present, although vaccination with inactivated vaccines is used as the most effective method, for example, influenza A virus cleverly changes its surface antigenicity, which often leads to a reduction in the therapeutic effect of th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/121A61P31/12A61P31/16A61P43/00
CPCA61K31/121A61P31/12A61P31/16A61P43/00
Inventor 西园晃鹈岛雅子岩坂日出男野口隆之
Owner EISIA R&D MANAGEMENT CO LTD
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