Bicarbonate hemodialysis agent without acetic acid

A bicarbonate and dialysis agent technology, applied in the field of hemodialysis agents, can solve the problems of expensive glycylglycine and restrict its wide use, achieve the effect of protecting normal cells and residual kidney function, low price, and overcoming adverse effects

Active Publication Date: 2008-01-09
GUANGZHOU BAIYUNSHAN MINGXING PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Glycylglycine is expensive, which restricts its widespread clinical use

Method used

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  • Bicarbonate hemodialysis agent without acetic acid

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0031] 1. Example 1: A component sodium chloride (NaCl) 1610g

[0032] Potassium chloride (KCl) 41.2g

[0033] Calcium chloride (CaCl 2 ·2H 2 O) 97.0g

[0034] Magnesium chloride (MgCl 2 ·6H 2 O) 59.9g

[0035] Glycine hydrochloride (NH 2 CH 2 COOH·HCl) 197.2g

[0036] B component sodium bicarbonate (NaHCO 3 ) 660.1g

[0037] Sodium chloride (NaCl) 304.9g

[0038] According to the above formula, prepare solid preparations of A and B components or add water to dissolve and dilute to 10L to make liquid preparations. Mix A liquid, B liquid and water according to the machine ratio of 1:1.83:34. The final ion concentration (mmol / L) is:

[0039] Na + K + Ca 2+ Mg 2+ Cl - Gly HCO 3 -

[0040] 139.7 1.5 1.8 0.8 112.2 4.8 39.0

example 2

[0041] 2. Example 2: A component sodium chloride (NaCl) 2168.1g

[0042] Potassium chloride (KCl) 78.3g

[0043] Calcium chloride (CaCl 2 ·2H 2 O) 77.2g

[0044] Magnesium chloride (MgCl 2 ·6H 2 O) 24.9g

[0045] Glycine hydrochloride (NH 2 CH 2 COOH·HCl) 97.6g

[0046] B component sodium bicarbonate (NaHCO 3 ) 700g

[0047] Sodium chloride (NaCl) 0

[0048] According to the above formula, prepare solid preparations of A and B components or add water to dissolve and dilute to 10L to make liquid preparations. Mix A liquid, B liquid and water according to the machine ratio of 1:1.26:32.74, and the final ion concentration (mmol / L) is:

[0049] Na + K + Ca 2+ Mg 2+ Cl - Gly HCO 3 -

[0050] 136 3.0 1.5 0.35 115.2 2.5 30.0

example 3

[0051] 3. Example 3: A component sodium chloride (NaCl) 1721.9g

[0052] Potassium chloride (KCl) 41.2g

[0053] Calcium chloride (CaCl 2 ·2H 2 O) 81.2g

[0054] Magnesium chloride (MgCl 2 ·6H 2 O) 37.5g

[0055] Glycine hydrochloride (NH 2 CH 2 COOH·HCl) 123.2g

[0056] B component sodium bicarbonate (NaHCO 3 ) 659g

[0057] Sodium chloride (NaCl) 282g

[0058] According to the above formula, prepare solid preparations of A and B components or add water to dissolve and dilute to 10L to make a liquid preparation. Mix A liquid, B liquid and water according to the machine ratio of 1:1.83:34. The final ion concentration (mmol / L) is:

[0059] Na + K + Ca 2+ Mg 2+ Cl - Gly HCO 3 -

[0060] 143 1.5 1.5 0.5 112.5 3.0 39.0

[0061] Take the formulation of Example 3 for stability test (accelerated for 6 months and long-term retention of samples for 12 months), the results are as follows:

[0062] Long-term retention sample 12

[0063] The above results show th...

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Abstract

The invention relates to an acetate acid free hemodialysis agent of bicarbonate. The hemodialysis agent is composed of constituent A and constituent B, constituent A: sodium chloride 77%-94%, potassium chloride 0%-4%, calcium chloride 2%-6%, magnesium chloride 1%-3%, glycine hydrochloride 3%-10%. constituent B: sodium bicarbonate 65%-100%, sodium chloride 0%-35%.

Description

Technical field [0001] The present invention relates to a hemodialysis agent in blood purification treatment, in particular to a bicarbonate hemodialysis agent including solid and liquid dosage forms. Background technique [0002] The currently commonly used bicarbonate hemodialysis preparations are divided into two components: A and B. The A component is mainly composed of sodium chloride (NaCl), potassium chloride (KCl), and calcium chloride (CaCl). 2 ), magnesium chloride (MgCl 2 ), acetic acid (HAc), B component is composed of sodium bicarbonate (NaHCO 3 ) Or add sodium chloride (NaCl). Before use, the solid preparation needs to be dissolved into a solution (concentrate) with purified water according to the regulations; the liquid preparation can be directly used for hemodialysis. When in use, the hemodialysis machine draws liquid A, liquid B, and water in proportions, and mixes them into the machine automatically to form a dialysate, and then hemodialysis is performed on the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61M1/14
Inventor 黎春罗建明周卫芬司徒少金
Owner GUANGZHOU BAIYUNSHAN MINGXING PHARM CO LTD
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