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Hydrophilic gel pleximetric paste and its preparation method

A technology of hydrophilic gel and transdermal patch, which is applied in the field of medicine and can solve the problems of low content of active ingredients, easy falling off, complex ingredients, etc.

Active Publication Date: 2008-06-04
湖北兵兵药业(集团)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, the hydrophilic gel transdermal patch developed by the existing technology has complex components and low content of active ingredients. Some products have certain irritation, are prone to sensitization, and are easy to fall off.
[0004] Bupleurum volatile oil is the volatile oil extracted from Bupleurum chinensis, a traditional Chinese medicine that has been widely used clinically. The main component of Bupleurum bupleurum injection used clinically is volatile oil. Influenza, malaria and other fevers are indeed curative (National Medicine Zhunzi Z41020926), and the application of Bupleurum volatile oil to the hydrophilic gel transdermal patch has not been seen so far.

Method used

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  • Hydrophilic gel pleximetric paste and its preparation method
  • Hydrophilic gel pleximetric paste and its preparation method
  • Hydrophilic gel pleximetric paste and its preparation method

Examples

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preparation example Construction

[0060] The specific preparation method is:

[0061] Disperse the hydrophilic gel, binder, volatile oil of Bupleurum, surfactant, penetration enhancer, and filler in the moisturizer under stirring conditions to form phase A, and disperse the crosslinking agent in the solvent evenly under stirring conditions Then, phase B is formed in phase B, and then phase B is stirred and evenly dispersed in phase A under certain vacuum conditions to form a gel layer, and then the gel layer is coated on the non-woven fabric, covered with a protective film, and cut to a certain size. It is cured at room temperature to produce a hydrophilic gel patch containing Bupleurum volatile oil.

Embodiment 1

[0063] The following formula:

[0064] (Bupleurum volatile oil) Bupleurum volatile oil 1.0%

[0065] (Penetration enhancer) oleic acid 4.0%, helium ketone 3.0%, PEG 4.0%

[0066] (Surfactant) Tween 1.0%

[0067] (Binder) Gelatin 1.0%

[0068] (Humectant) Propylene glycol 5.0% Glycerin 24%

[0069] (Hydrophilic gel) Sodium polyacrylate 4.0%

[0070] (Solvent) water 53.0%

[0071] The preparation method is: disperse sodium polyacrylate, gelatin, Bupleurum volatile oil, Tween, oleic acid, helium ketone, and PEG in propylene glycol and glycerin (phase A) under stirring conditions. The solvent water is phase B, and then B The phase is stirred and evenly dispersed in phase A under certain vacuum conditions to form a gel layer, and then the gel layer is coated on a non-woven fabric, covered with a protective film, cut to a certain size, and cured at room temperature to produce a Hydrophilic gel patch of Hu volatile oil.

Embodiment 2

[0073] (Bupleurum volatile oil) Bupleurum volatile oil 5.0%

[0074] (Penetration enhancer) oleic acid 1.0%, helium ketone 3.0%, PEG 1.0%

[0075] (Surfactant) Tween 2.0%

[0076] (Binder) Gelatin 1.0%

[0077] (Humectant) Propylene glycol 5.0% Glycerin 25%

[0078] (Hydrophilic gel) Sodium polyacrylate 4.0%

[0079] (Solvent) water 53%

[0080] The preparation method is the same as in Example 1

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Abstract

A percutaneous paster of hydrophilic gel for medicine features that its gel layer contains the volatile oil of bupleurum root, hydrophilic gel, cross-linking agent, humectant, surfactant, filler, adhesive, osmosis promoter and solvent. Its preparing process is also disclosed.

Description

Technical field [0001] The invention relates to the technical field of medicine, in particular to a hydrophilic gel transdermal patch for drug transdermal controlled release therapy and a preparation method thereof. Background technique [0002] Hydrophilic gel transdermal patch (pabu ointment) is a topical patch made of water-soluble polymer compounds or hydrophilic substances as the matrix, mixed with medicines or Chinese medicine extracts, and coated on a non-woven fabric sheet. It has good skin biocompatibility, affinity, breathability, sweat resistance and repeated peeling properties, and it is not easy to be allergic. In the early 1970s, Japan, Europe and other countries have begun to develop medical cataplasm. With the continuous development of the pharmaceutical industry, this new dosage form has developed in my country in recent years. According to the prediction of the World Health Organization, in the next few years, more than 30% of the drugs will be changed to transd...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/233A61K9/70A61K9/00A61K47/42A61K47/32A61K47/46A61P29/00
Inventor 曾婕王海波
Owner 湖北兵兵药业(集团)有限公司
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