Medicine for treating cardiac and cerebral vascular diseases and its preparation

A technology for cardiovascular and cerebrovascular diseases and pharmaceutical preparations, which is applied to cardiovascular system diseases, drug combinations, and pharmaceutical formulations. It can solve the problems of low toxicity and side effects, and achieve the effects of low toxicity, good curative effect, and significant therapeutic effect

Active Publication Date: 2008-12-31
深圳市资福药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no effective drug with good curative effect and less toxic and side effects to cure most patients with "ischemic stroke and coronary heart disease angina pectoris"

Method used

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  • Medicine for treating cardiac and cerebral vascular diseases and its preparation
  • Medicine for treating cardiac and cerebral vascular diseases and its preparation
  • Medicine for treating cardiac and cerebral vascular diseases and its preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] (1) Take 1000g of honeysuckle and add 10 times the amount of ethanol (75%), reflux extraction 3 times, 2, 3, 2 hours respectively, combine the extracts, concentrate until each 1ml is equivalent to 1.0g of crude drug, add the same amount of water, and refrigerate After 30 hours, filter, recover ethanol under reduced pressure until ethanol is not contained in the extract, extract 4 times with an equal amount of ethyl acetate, combine the extracts, recover ethyl acetate under reduced pressure, add a small amount of water for injection to the extract, and continue to evaporate to dryness to obtain Effective part of honeysuckle.

[0028] (2) Mix 1000g Achyranthes bidentata, 1000g Scrophulariaceae, and 1000g Dendrobium, add 10 times the amount of water, decoct and extract 3 times, respectively for 3, 2, and 2 hours, combine the extracts, and concentrate until each 1ml is equivalent to 1.0g of crude drug , add ethanol to precipitate to make the alcohol content reach 80%, refri...

Embodiment 2

[0032] Prepare the pharmaceutical preparation injection Z-2 of the present invention according to the method of Example 1, just get 500g of honeysuckle in the (1) step, ethanol concentration is 55%, and ethanol amount is 12 times of amount, every 1ml after concentration is equivalent to containing crude drug 1.2 g; in step (2), take 400g of Achyranthes bidentata, 600g of Scrophulariaceae, and 300g of Dendrobium, add 12 times the amount of water, decoct and extract 4 times, respectively for 3, 2, 2, and 1 hour, and after concentration, it is equivalent to containing 0.8g of crude drug / ml, add ethanol precipitation to make the alcohol content reach 75%.

Embodiment 3

[0034] Prepare pharmaceutical preparation injection Z-3 of the present invention according to the method for embodiment 1, just extracting agent is propylene glycol in (1) step, and extracting agent is ethylene dichloride; Precipitate with isopropanol in (2) step, diethyl ether extraction.

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PUM

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Abstract

The medicine preparation for treating cardiac and cerebral vascular diseases is prepared with honeysuckle, achyranthes root, figwort and dendrobium stem as material. The preparation process includes extracting honeysuckle with extracting agent to obtain effective honeysuckle part; water extracting and alcohol depositing achyranthes root, figwort and dendrobium stem and extracting the solution to obtain the first effective part of achyranthes root, figwort and dendrobium stem; purifying the deposit to obtain the second effective part of achyranthes root, figwort and dendrobium stem; compounding the said effective parts to obtain injection; or adding osmotic pressure regulator and injection water to obtain transfusion liquid; or adding excipient and freeze drying to obtain medicine powder for injection. The medicine preparation has high curative effect on ischemic apoplexy, coronary heart disease, angina pectoris, etc.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to pharmaceutical preparations for treating cardiovascular and cerebrovascular diseases and a preparation method thereof. technical background [0002] Cardiovascular and cerebrovascular diseases are great enemies that endanger human health. The annual mortality rate of cardiovascular and cerebrovascular diseases in my country remains high. At present, there is no effective drug with good curative effect and little toxic and side effects to cure most patients with "ischemic stroke and coronary heart disease angina pectoris". Contents of the invention [0003] In order to overcome the deficiencies of the prior art, the object of the present invention is to provide a high-efficiency and low-toxic pharmaceutical preparation for treating cardiovascular and cerebrovascular diseases, especially for treating ischemic stroke and coronary heart disease angina pectoris. [0004]...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8984A61K36/808A61K36/35A61K36/21A61K9/14A61K9/19A61P9/10
Inventor 吴良信
Owner 深圳市资福药业有限公司
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