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Aquogel type thiamazole plaster preparation

A technology of methimazole and hydrogel, which is applied in the field of medicine, can solve the problems of poor air permeability and water permeability, loss of viscosity, environmental pollution, etc., achieve excellent bonding performance, improve cohesive strength, and have no environmental pollution effects

Inactive Publication Date: 2009-01-14
HUAZHONG UNIV OF SCI & TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The object of the present invention is to provide a kind of hydrogel-type methimazole patch with good biocompatibility with skin, good breathable and water-permeable performance, repeated peeling, suitable bonding performance, large drug loading capacity and good percutaneous penetration effect , to overcome the poor biocompatibility of the patches prepared by traditional pressure-sensitive adhesives, poor air permeability and water permeability, which lead to skin damage caused by long-term use, poor percutaneous penetration of drugs, and loss of viscosity when exposed to water, cannot be repeatedly peeled off, excessive peel strength, and in production Organic solvents cause environmental pollution and other disadvantages

Method used

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  • Aquogel type thiamazole plaster preparation
  • Aquogel type thiamazole plaster preparation
  • Aquogel type thiamazole plaster preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0051] The present invention is further illustrated by the following examples. The composition and properties of the formulations of Examples 1-18 are listed in Table 1 and Table 2 respectively.

[0052] Those skilled in the art can implement the content disclosed in the present invention with reference to the above-mentioned embodiments. Accordingly, the preferred embodiments of the present invention are to be understood as illustrative only and not restrictive of the present invention in any way.

[0053] Table 1 embodiment 1~18 hydrogel type methimazole patch prescription (total amount is calculated by 100 grams)

[0054] Reality

apply

example

Methylthio

imidazole

content

(gram)

molecular weight of PAA

(10,000) / segment ratio / including

Quantity (grams)

Crosslinking agent / content

(gram)

pH adjustment

Agent / Content

(gram)

Moisturizer / Con...

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PUM

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Abstract

The aquogel type thiamazole plaster includes a back lining layer, a medicine matrix layer and a protecting film. The medicine matrix layer contains medicine thiamazole in 0.2-20 wt% of the medicine matrix layer, aquogel type contact adhesive material, cross-linking agent, pH regulator, humectant, tackifier medicine, transdermal promoter and water, . The present invention has high transdermal effect of medicine, good skin compatibility, high air and moisture permeability, lowered toxicity and side effect of medicine and other advantages, and is used for treating hyperthyroidism.

Description

technical field [0001] The invention relates to a hydrogel-type methimazole patch, which belongs to the technical field of medicine. Background technique [0002] Hyperthyroidism (referred to as hyperthyroidism) is a common endocrine disease caused by increased thyroid function and excessive secretion of thyroid hormones, resulting in increased basal metabolic rate. Methimazole (Thiamazole, also known as methimazole, methimazole, methhiazole, mecarbazolil) can inhibit the synthesis of thyroid hormones, and is a representative drug for the clinical treatment of hyperthyroidism. Its chemical name is 1 -Methylimidazole-2-thiol, the molecular formula is: C 4 h 6 N 2 S (molecular weight: 114.16). [0003] At present, the commonly used preparation for the clinical treatment of hyperthyroidism is methimazole tablet. Due to the short biological half-life of methimazole (less than 3 hours), the oral dose of the drug is large and the frequency of taking is frequent, which makes i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4164A61K9/70A61K47/00A61P5/16
Inventor 刘卫周小顺左新河陈如泉魏小藏杨祥良
Owner HUAZHONG UNIV OF SCI & TECH
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