Complexus containing polylactic acid and native copper, and its use

A natural copper and complex technology, applied in medical science, prosthesis, surgery, etc., can solve the problems of high cost of biologically active proteins, difficult to store for a long time, and difficult to sterilize products, and achieves the goal of avoiding easy inactivation, convenient operation, and promoting The effect of proliferation and differentiation of osteoblasts

Inactive Publication Date: 2009-08-12
CHENGDU ORGANIC CHEM CO LTD CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In the prior art, the substances with osteoinductive activity are mainly some bioactive proteins, such as bone morphological protein (BMP), etc., but the cost of bioactive proteins is high, easy to inactivate, and difficult to detect, and its products are not easy to be sterilized and difficult to maintain for a long time. Storage, these disadvantages make it difficult to be widely used in clinical

Method used

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  • Complexus containing polylactic acid and native copper, and its use

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Preparation 20ml concentration is 2% (mass volume ratio) poly DL-lactic acid (molecular weight 270,000) 1,4-dioxane solution, adds natural copper powder by the mass ratio of poly DL-lactic acid 90%, natural copper 10% , stir to disperse. Pour it into a dish with a diameter of 19.5 cm, and dry it in vacuum for 48 hours to obtain a polylactic acid composite natural copper casting film with a film thickness of about 90 μm.

Embodiment 2

[0028] Preparation 20ml concentration is 2% (mass volume ratio) poly DL-lactic acid (molecular weight 270,000) 1,4-dioxane solution, adds natural copper powder by the mass ratio of poly DL-lactic acid 95%, natural copper 5% , stir to disperse. Pour it into a tray and dry it in vacuum for 48 hours to obtain a polylactic acid composite natural copper casting film with a film thickness of about 84 μm.

Embodiment 3

[0030] Preparation 20ml concentration is 2% (mass volume ratio) poly DL-lactic acid (molecular weight 900,000) 1,4-dioxane solution, adds natural copper powder by the mass ratio of poly DL-lactic acid 60%, natural copper 40% , stir to disperse. Pour it into a tray and dry it in vacuum for 48 hours to obtain a polylactic acid composite natural copper casting film with a film thickness of about 105 μm.

[0031] 2. Preparation of polylactic acid composite natural copper porous membrane:

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Abstract

The invention discloses a compound of polylactic acid and natural copper, in terms of mass percentage: 60%-99% of polylactic acid, 1%-40% of natural copper; wherein, polylactic acid is poly-L-lactic acid, poly-DL-lactic acid , A copolymer of lactic acid-glycolic acid, with a molecular weight of 2 to 1.3 million. The compound of the present invention can be processed into a variety of medical devices, such as membranes, three-dimensional scaffolds, bone defect filling particles, bone screws, bone splints, bone rods, spinal fusion devices, etc., and has good biocompatibility and absorbability , and has an osteoinductive effect.

Description

technical field [0001] The invention relates to a composite of polylactic acid and natural copper and its application in medical devices. Background technique [0002] Bone repair refers to the repair and reconstruction of bone defects and deformities caused by various diseases such as trauma, infection, and tumors, so that bone tissue can restore its structure and function as quickly and completely as possible. At present, porous scaffolds are mostly used in the bone repair process to provide a three-dimensional support system for tissue cells to host, grow, value-added and differentiate. Therefore, scaffold materials are required not only to have good biocompatibility, degradability, Sufficient mechanical properties and good biomechanical adaptability, but also good osteoconductivity and osteoinductivity to promote the growth and differentiation of bone cells. [0003] At present, there are many types of materials used to prepare porous scaffolds: one is biodegradable syn...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/44A61L31/12C08L67/04C08K3/08
Inventor 熊成东张丽芳孙蕊
Owner CHENGDU ORGANIC CHEM CO LTD CHINESE ACAD OF SCI
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