Titanium alloy with osteoinductive activity for bone fixing apparatus

A technology for fixation devices and titanium alloys, applied in the field of titanium alloys for bone fixation devices, can solve the problems of unresolved wear resistance, lack of osteoinductive activity, and unguaranteed bonding strength, etc., to achieve improved thermodynamic stability, good bone Effect of inducing activity and enhancing bone growth activity

Inactive Publication Date: 2018-10-30
THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
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  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

[0003] However, the application of new titanium alloy medical materials has the following disadvantages: ①No osteoinductive activity; ②Titanium alloy has poor wear resistance. During use, it will cause wear and tear due to human joint activities, and the resulting debris will cause tissue reactions.
[0005] The domestic patent application No. 201510508585.2 discloses a preparation method of a medical bone fixation device, but does not solve the problem of wear resistance; the application No. 201710979298.9 discloses a medical titanium alloy and its preparation method, which has good wear resistance but does not have Osteoinductive activity; application number 201510476616.0 published a medical titanium alloy rod, and application number 201510476615.6 published a medical titanium alloy rod with strong antibacterial ability. Both patented technologies are coated on the outer layer of the titanium alloy rod coating, bond strength cannot be guaranteed

Method used

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  • Titanium alloy with osteoinductive activity for bone fixing apparatus

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] 1) Ingredients: by mass percentage: Zn 4.5%, Fe 3%, Mo 0.75%, Sr 0.5%, Se 0.5%, Mn 0.5%, Cu0.3%, nano silver wire 1.8%, ZrO 2 8.2%, K 2 CO 3 0.6%, B 0.7%, Zr 15%, carbon nanotube 0.2%, the balance is Ti;

[0019] 2) Preparation of master alloy: the master alloy has two kinds of I and II; the master alloy I is made of nano-silver wire and ZrO 2 Sintering preparation, the nano-silver wire diameter is 80nm, the ZrO 2 The particle size of the particles is 0.3 μm, and they are sintered in a vacuum induction furnace at a temperature of 600-660°C and a time of 30-45 minutes; the master alloy II is composed of K 2 CO 3 , B, Zr, and carbon nanotubes, smelted in a vacuum induction furnace at a temperature of 1800-1850°C, and poured into a graphite mold after holding for 2 hours to obtain an alloy ingot;

[0020] 3) Smelting and casting: Put Zn, Fe, Mo, Sr, Se, Mn, Cu, master alloy I, master alloy II, Ti and other raw materials into the non-consumable electrode water-cooled...

Embodiment 2

[0025] 1) Ingredients: by mass percentage: Zn 5%, Fe 3.5%, Mo 0.8%, Sr 0.6%, Se 0.5%, Mn 0.6%, Cu 0.35%, nano silver wire 1.8%, ZrO 2 8.2%, K 2 CO 3 0.6%, B 0.7%, Zr 15%, carbon nanotube 0.25%, the balance is Ti;

[0026] 2) Preparation of master alloy: the master alloy has two kinds of I and II; the master alloy I is made of nano-silver wire and ZrO 2 Sintering preparation, the nano-silver wire diameter is 90nm, the ZrO 2 The particle size of the particles is 0.35 μm, which is sintered in a vacuum induction furnace at a temperature of 600-660°C and a time of 30-45 minutes; the master alloy II is composed of K 2 CO 3 , B, Zr, and carbon nanotubes, smelted in a vacuum induction furnace at a temperature of 1800-1850°C, and poured into a graphite mold after holding for 2 hours to obtain an alloy ingot;

[0027] 3) Smelting and casting: Put Zn, Fe, Mo, Sr, Se, Mn, Cu, master alloy I, master alloy II, Ti and other raw materials into the non-consumable electrode water-cooled ...

Embodiment 3

[0032] 1) Ingredients: by mass percentage: Zn 5.5%, Fe 4.8%, Mo 0.8%, Sr 0.5%, Se 0.5%, Mn 0.5%, Cu0.3%, nano silver wire 1.8%, ZrO 2 8.2%, K 2 CO 3 0.6%, B 0.9%, Zr 18%, carbon nanotube 0.4%, the balance is Ti;

[0033]2) Preparation of master alloy: the master alloy has two kinds of I and II; the master alloy I is made of nano-silver wire and ZrO 2 Sintering preparation, the nano-silver wire diameter is 100nm, the ZrO 2 The particle size of the particles is 0.5 μm, which is sintered in a vacuum induction furnace at a temperature of 600-660°C and a time of 30-45 minutes; the master alloy II is composed of K 2 CO 3 , B, Zr, and carbon nanotubes, smelted in a vacuum induction furnace at a temperature of 1800-1850°C, and poured into a graphite mold after holding for 2 hours to obtain an alloy ingot;

[0034] 3) Melting and casting: put Ca, Zn, Fe, Mo, Sr, Se, Mn, Cu, master alloy I, master alloy II, Ti and other raw materials into the non-consumable electrode water-cooled...

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Abstract

The invention provides a titanium alloy with osteoinductive activity for a bone fixing apparatus. The titanium alloy comprises the following chemical components in percentage by mass: 3-8% of Zn, 2-6%of Fe, 0.5-1.2% of Mo, 0.5-1.0% of Sr, 0.5-1.2% of Se, 0.4-1.0% of Mn, 0.2-0.8% of Cu, 1.8% of a nanosilver wire, 8.2% of ZrO2, 0.5-1.2% of K2CO3, 0.6-1.2% of B, 12-20% of Zr, 0.2-0.5% of a carbon nanotube and the balance Ti. A preparation process of the titanium alloy provided by the invention comprises the following steps: first, preparing an intermediate alloy I (the intermediate alloy is prepared by sintering the nanosilver wire and ZrO2) and an intermediate alloy II (the intermediate alloy II is prepared by smelting K2CO3, B, Zr and the carbon nanotube); and then carrying out cast forming after smelting other raw materials and the intermediate alloys I and II and carrying out corresponding thermal treatment. The obtained titanium alloy is excellent in mechanical property and has goodosteoinductive activity and an antibacterial function.

Description

technical field [0001] The invention belongs to the technical field of new medical materials, in particular to a titanium alloy for bone fixation devices with osteoinductive activity. Background technique [0002] With the development of modern medicine and materials science, metal materials have become the most widely used clinical implant materials due to their good mechanical properties and processing properties. Bone fixation devices are medical devices implanted in the human body. The metal materials used to manufacture bone fixation devices mainly include cobalt alloys, nickel-chromium alloys, and titanium alloys. Titanium alloys have been widely used for their excellent mechanical properties and good biocompatibility. [0003] However, the application of new titanium alloy medical materials has the following disadvantages: ①No osteoinductive activity; ②Titanium alloy has poor wear resistance. During use, it will be worn due to human joint activities, and the resultin...

Claims

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Application Information

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IPC IPC(8): C22C14/00C22C1/03C22C1/10C22C26/00C22F1/18
CPCC22C1/1036C22C14/00C22C26/00C22F1/183C22C2026/002C22C1/1047
Inventor 周南刘小康汪济海张翼王文刚王伟伟李峰王峥
Owner THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
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