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Anti-cancer and anti-infectious disease compositions and methods for using same

A composition and virus technology, applied in the field of tumor treatment, can solve the problem of weak ability of tumor cells to present antigens

Inactive Publication Date: 2010-01-13
CHIRON CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0034] Although immunotherapy has the above advantages, it is still limited by the following factors in order to succeed: (1) tumor-specific antigenicity, so this treatment method is only limited to certain types of tumors; Weak ability to present antigens; and (3) tumor cells can produce immunosuppressive factors to evade immune surveillance

Method used

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  • Anti-cancer and anti-infectious disease compositions and methods for using same
  • Anti-cancer and anti-infectious disease compositions and methods for using same
  • Anti-cancer and anti-infectious disease compositions and methods for using same

Examples

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Embodiment 7

[0086] Accordingly, the present invention provides methods for treating patients in need of anticancer therapy, including inhibiting tumor growth, inhibiting tumor metastasis, and inducing tumor resistance by administering non-pathogenic viruses to the patient. Notably, the tumor treatment regimens described herein do not require the identification of tumor-specific antigens. Therefore, non-pathogenic viruses have a wide range of applications and have curative effects on various types of tumors. See Examples 2-6.

Embodiment 2-6

[0087] While the inventors do not wish to be bound by a particular mode of operation, the inventors believe that the anticancer activity of the non-pathogenic virus is attributable, at least in part, to its immunostimulatory activity. For example, baculovirus induces dendritic cell maturation and cytotoxic T cell (CTL) responses both in vitro and in vivo. See Examples 9-10. See also Gronowski et al. (1999) J Virol. 73:9944-51.

[0088] The term "virus" as used herein is used to describe an effective anti-tumor composition, including live virus, inactivated virus, viral particles, viral inclusion bodies, virosomes, virus-like particles, viral components and mixtures thereof.

[0089] Virosomes and virus-like particles (VLPs) typically contain one or more proteins of a non-pathogenic virus, optionally with the addition of phospholipids. In certain embodiments, virions and VLPs are non-replicating and do not contain any native viral genome. Viral proteins can be produced by re...

Embodiment 17

[0122] In order to screen non-pathogenic viruses with anti-infectious disease activity, the in vitro or in vivo anti-infectious disease detection methods well known to those skilled in the art are used to detect candidate non-pathogenic viruses. For example, for tuberculosis, a TB model or an in vitro macrophage model can be used to test the anti-infectious disease activity of the virus. Abe et al., (Journal of Immunology, 2003, 171:1133-1139) describe other methods suitable for testing the activity of compounds against infectious diseases.

[0123] In some embodiments, in vitro tests are used to conduct preliminary screening, and then to evaluate whether those viruses with in vitro activity also have anti-infectious disease activity in vivo in related animal models.

[0124] Accordingly, the present invention also provides methods of treating a patient in need of anti-infectious disease treatment by administering to the patient a non-pathogenic virus. Notably, the non-pathog...

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Abstract

The invention provides a method to treat and / or prevent tumors through delivering non-pathogenic virus to testees, and a compound thereof. The invention also provides a method to treat and / or prevent infectious diseases through delivering non-pathogenic virus to testees, and a compound thereof.

Description

field of invention [0001] The present invention relates to the field of tumor treatment, more specifically, the present invention relates to the application of non-pathogenic viruses as effective anticancer drugs. Background of the invention [0002] List of abbreviations [0003] A549 - human lung epithelial tumor cell line [0004] AcNPV - Autographa californica nuclear polyhedrosis virus [0005] BMDC - bone marrow-derived dendritic cells [0006] BV422 - recombinant baculovirus expressing CCL21 [0007] BV762 - recombinant baculovirus expressing Raf [0008] CCL21 -C-C motif ligand 21 chemokine; secondary lymphoid tissue chemokine [0009] CD86 - a marker of dendritic cell maturation [0010] CR - fully valid [0011] CTL - cytotoxic T cell lysis [0012] DC - dendritic cells [0013] FACS - Fluorescence Activated Cell Sorting [0014] GM-CSF - Granulocyte-Macrophage Colony Stimulating Factor [0015] GV - Granular virus [0016] HIV - human immunodeficiency ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K39/12A61K48/00A61K31/00A61K31/501A61P25/00C07D401/14C07D403/06C07D409/14C07D417/14
CPCC07D401/14C07D417/14C07D409/14C07D403/06A61P25/00A61P25/20A61P25/22A61P25/24A61P25/28A61P43/00
Inventor W·M·卡瓦诺D·L·斯隆M·L·麦克占
Owner CHIRON CORP
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