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Use of ginseng fruit extract for preparing anti-anoxia medicine
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A technology of anti-hypoxia drugs and extracts, applied in drug combinations, antidote, pharmaceutical formulations, etc., can solve the problems of less research, insufficient detailed mechanism research, and limited overall level of animals.
Inactive Publication Date: 2011-04-27
LOGISTICS UNIV OF CAPF
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Problems solved by technology
[0004] The applicant believes that the current anti-hypoxia research of traditional Chinese medicine still has the following problems: (1) There are more researches on the overall aspect, and less research on the cellular level; (2) Research on pharmacodynamics, The research on its mechanism of action is not detailed enough; (3) How to screen a wide variety of anti-hypoxic Chinese medicines from the mechanism of action under the guidance of TCM theory; (4) Whole, in vitro and cellular Horizontal models, strict control of experimental conditions and standardization of modeling, enable the screening of anti-hypoxic drugs to a new level
[0007] According to the following documents, the applicant believes that the current domestic research on the anti-hypoxia effect of Zernia is only limited to the experiment of raw materials, and the effective parts or components of Zerna have not been clarified or disclosed, and the experimental research so far is only limited to the overall level of animals. These documents are:
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preparation example Construction
[0021] The preparation method of the fern extract of the present invention is as follows:
[0022] Take the dry root tubers of Bracken, crush them, add 8 times the amount of 90% ethanol, reflux at 80°C for 2 hours, repeat twice, combine the extracts, concentrate under reduced pressure to a specific gravity of about 1.40g / ml, and obtain the alcoholic extract. Disperse the extract with 3 times the amount of water, sequentially extract 3 times with petroleum ether, ethyl acetate and n-butanol equivalent to 1 / 3 volume of the water dispersion system, combine the n-butanol liquid, concentrate under reduced pressure, and freeze-dry to obtain normal butanol site.
[0023] The following is the experimental description of the anti-hypoxic effect of the n-butanol part of Bracken:
[0024] Experiment 1 Mouse specific myocardial hypoxia experiment
[0025] 1. Method:
[0026] 75 Kunming mice, weighing (20±2) g. They were randomly divided into 5 groups and administered by intragastric a...
Embodiment 1
[0072] Embodiment 1, the fern extract is made into tablet:
[0073] Butanol fraction of Bracken 50mg
[0074] Starch 25mg
[0075] 15% starch slurry appropriate amount
[0076]Magnesium Stearate Appropriate amount
[0077] The above formula is made into tablets according to traditional processing methods.
Embodiment 2
[0078] Embodiment 2, the fern extract is made into capsules:
[0079] Butanol fraction of Bracken 50mg
[0080] Starch 70mg
[0081] Prepared according to the traditional pharmaceutical process, put into No. 2 capsules.
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Abstract
An application of the extract of potentilla anserine in preparing the medicines for preventing and treating anoxia is disclosed.
Description
Technical field: [0001] The invention relates to a pharmaceutical product, which is composed of a fern extract and a pharmaceutically acceptable carrier. The product can be used to prevent and treat hypoxic injury diseases. Background technique: [0002] Oxygen is an important condition for the survival of human beings and many organisms. Hypoxia refers to the insufficient supply of oxygen required by the body's life activities. Oxygen and hypoxia are the most important key factors in life activities, and are important topics in the basic theory of life sciences. The formation of hypoxia can be divided into three categories: the first category is that the oxygen content of the external environment is reduced, so that the normal physiological activities cannot take in enough oxygen, such as plateau and aviation hypoxia; the second category is the normal oxygen level caused by diseases, etc. Can not fully reach the body, causing hypoxia in the heart, brain and respiratory s...
Claims
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Application Information
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