Traditional Chinese medicine achyranthes extract and preparation method and use thereof

An extract and Achyranthes technology, which is applied in the field of extracts of natural plant substances, can solve rare problems, and achieve the effects of clear preparation ingredients, single source of medicinal materials, and nerve growth promotion.

Inactive Publication Date: 2007-08-08
NANTONG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, so far there are few new Chinese medicines that can effectively promote nerve growth and prevent neurodegeneration clinically, and cannot meet the needs of clinical patients.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1: Preparation and effect of Radix Achyranthes Radix Extract A

[0013] Take the decoction pieces of Achyranthes bidentata, soak in water for 1 hour, extract twice with 10, 8, and 6 times the amount of water at 80°C (or 10°C, 50°C), each time for 1 hour, combine the extracts, and pass through the gel. Column (Sephadex-G50) chromatographic separation and purification, eluting with water, freeze-drying the eluate at -30~-50°C, and aliquoting to obtain Product A. The main components of A are sterone, polysaccharide, etc., which can promote nerve growth and prevent neuron apoptosis in vivo and in vitro. It can be used to prepare drugs and health care products for anti-aging, prevention and treatment of neurodegenerative diseases, and treatment of neurological damage diseases such as cerebral apoplexy, optic nerve injury, spinal cord injury and peripheral nerve injury.

Embodiment 2

[0014] Embodiment 2: Preparation and effect of Radix Achyranthes Radix Extract B

[0015] Take the decoction pieces of Achyranthes bidentata, heat and reflux with 8, 6, and 4 times the amount of 70% ethanol aqueous solution to extract three times, each time for 2 hours, combine the extracts, and recover ethanol under reduced pressure. The extract was separated and purified by gel column (Sephadex-G50) chromatography, eluted with water, and the eluate was freeze-dried at -30~-50°C, and then packaged to obtain product B. The main components of B are sterone, polysaccharide, etc., which can promote nerve growth and prevent neuron apoptosis in vivo and in vitro. It can be used to prepare drugs and health care products for anti-aging, prevention and treatment of neurodegenerative diseases, and treatment of neurological damage diseases such as cerebral apoplexy, optic nerve injury, spinal cord injury and peripheral nerve injury.

Embodiment 3

[0016] Embodiment 3: Preparation and effect of Radix Achyranthes Radix Extract C

[0017] Take the decoction pieces of Achyranthes bidentata, heat and reflux extract with 8, 6, and 4 times the amount of 95% ethanol aqueous solution for three times, each time for 2 hours, combine the extracts, and recover the ethanol under reduced pressure. The extract was separated and purified by gel column (Sephadex-G50) chromatography, eluted with water, and the eluate was freeze-dried at -30~-50°C, and then packed to obtain C. The main components of C are sterone, polysaccharide, etc., which can promote nerve growth and prevent neuron apoptosis in vivo and in vitro, and can be used to prepare anti-aging, prevent and treat neurodegenerative diseases, and treat stroke, optic nerve injury, spinal cord injury, Drugs and health products for nerve damage diseases such as peripheral nerve injury.

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Abstract

The invention relates to a method for preparing achyranthes extractive, which comprises that using 0-95% alcohol solution to extract the achyranthes for 1-3 times, combining the extractives, using gel post chromatography to separate and purify, freezing and drying the eluent, to obtain the product, which can be used to prepare the drug for treating cerebral apoplexy, optic nerve hurt or the like. The invention has high safety, significant drug effect, and wide application.

Description

Technical field: [0001] The invention relates to an extract, an extraction method and application of a natural plant substance. Background technique: [0002] With the development of modern society, traffic accidents, wars, natural disasters, population aging and other factors, the incidence of nerve damage and degenerative diseases of the nervous system is on the rise. Find ways to promote the repair of damaged nerves, prevent and treat nervous system degeneration Effective medicine for sex change is a topic that attracts attention in current medical research. [0003] Traditional Chinese medicine is a great treasure house of Chinese medical science. It has the advantages of definite curative effect and less toxic and side effects. It is valued not only by domestic medical circles but also by colleagues in the world. Traditional Chinese medicine has accumulated a lot of experience in treating nerve injury and neurodegenerative diseases, and there are many clinical reports....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/21A61P39/06A61P25/02A61P25/00A61P9/10A61K125/00
Inventor 丁斐顾晓松杨宇民姚登兵
Owner NANTONG UNIVERSITY
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