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Chinese traditional medicine for treating hyperlipemia, and preparation method

A technology for hyperlipidemia and traditional Chinese medicine is applied in the field of traditional Chinese medicine for treating hyperlipidemia and its preparation, and achieves the effects of high curative effect, safe medication and low effective dose

Active Publication Date: 2010-12-22
GUANGZHOU YIPINHONG PHARMA +4
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, by extracting and separating the effective components of Polygonum cuspidatum, stilbene and anthraquinone complexes from Polygonum cuspidatum through a relatively simple method, the effective parts are formed in an appropriate proportion, and a new drug for regulating blood lipids and treating arteriosclerosis—Zhimaikang dispersible tablets is made. Not yet seen in the prior art

Method used

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  • Chinese traditional medicine for treating hyperlipemia, and preparation method

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Experimental program
Comparison scheme
Effect test

Embodiment

[0011] Embodiment: the preparation method of Zhimaikang dispersible tablet:

[0012] 1. Take the prescribed amount of Polygonum cuspidatum, slice it, dry it at 70-80°C, and crush it into coarse powder. Add 95% ethanol, heat and reflux for extraction three times (5 times, 1.5h, 4 times for 1h, 3 times for 0.5h), and filter.

[0013] 2. Concentrate the filtrate in vacuum (temperature 50-65°C, vacuum 0.07-0.08mpa) to 1ml equivalent to 1g crude drug, add 2% activated carbon to decolorize by boiling for 10 minutes, filter, and then concentrate the filtrate in vacuum (temperature 50-65°C, Vacuum 0.07-0.08mpa) to clear paste with a relative density of 1.15-1.20.

[0014] 3. Add 10 times the amount of water to the clear ointment, heat to a slight boil for 5 minutes, stir well, cool to room temperature, let stand for 12 hours, separate the upper aqueous solution, and concentrate in vacuum (temperature 50-65°C, vacuum 0.07-0.08mpa) To the clear paste with a relative density of 1.15-1....

Embodiment approach

[0033] In order to examine the feasibility of large-scale production and the adaptability of the small test of Polygonum cuspidatum extract and purification, and to further modify and perfect the small test process, 100kg of Polygonum cuspidatum (PD glycoside content 1.38%) was taken from each batch, and three batches of pilot tests were carried out continuously Zoom in and record the process parameters. The results are shown in the table below:

[0034] Pilot scale-up test result table

[0035]

[0036] The results show that the process is easy to operate, the equipment is suitable, the cost is low, the yield of the product is stable, and the content of flavonol glycosides and terpene lactones is qualified. And it is consistent with the Chinese Pharmacopoeia Ginkgo biloba extraction method. Suitable for industrial mass production.

[0037] Process summary:

[0038] 1. Pre-treatment of medicinal materials: the medicinal materials are the roots and rhizomes of Polygonum ...

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PUM

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Abstract

A Chinese medicine for preventing and treating hyperlipemia and arteriosclerosis is prepared from giant knotweed rhizome through pulverizing, extracting in alcohol, concentrating, depositing in water, concentrating, depositing in ethyl acetate, crystallizing in 5% acetone solution, and recrystallizing in diluted alcohol.

Description

technical field [0001] The invention belongs to a traditional Chinese medicine for treating hyperlipidemia and a preparation method thereof Background technique [0002] China New Drug Practical Encyclopedia records that among the Chinese patent medicines approved for production for the treatment of hyperlipidemia from 1985 to 2000, except for a few species such as gypenosides preparations and beeswax capsules, most of them are medicines made from compound Chinese medicines. Due to the complex composition and unclear active ingredients, the quality is difficult to control. Therefore, the curative effect is unstable and the effect is slow; and because most of them are crude extracts or crude drug powder preparations, they are bulky and inconvenient to take. It can only be used in conjunction with western medicine; the experimental research on the treatment of hyperlipidemia with resveratrol glycosides and resveratrol monomers extracted and separated from Polygonum cuspidatum...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/704A61K9/20A61K9/48A61P3/06A61K125/00
Inventor 彭源贵
Owner GUANGZHOU YIPINHONG PHARMA
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