Medicinal composition and preparation for treating irritable bowel syndrome and preparation method thereof

Abstract

The invention discloses a medicinal composition for treating irritable bowel syndrome comprising white peony root (fried) 65-70g, bighead atractylodes rhizome (fried) 35-45g, longstamen onion bulb 35-45g, plantain seed 35-45g, finger citron 35-45g, mint oil 1-2ml. The advantages of the invention are that it can relieve diarrhea, relax spasm, stop pain, tranquilize the mind, strengthen spleen and reinforce the right. The medicine shows favorable effect in treating diarrhea and pain caused by IBS.

Description

technical field

[0001] The invention relates to a pharmaceutical composition, preparation and preparation method for treating irritable bowel syndrome, belonging to the field of traditional Chinese medicine. Background technique

[0002] Irritable bowel syndrome (Irritable bowel syndrome, IBS) is a common digestive system functional disease, including a group of abdominal pain, bloating, abnormal bowel habits and stool characteristics, continuous or intermittent episodes, and lack of obvious morphological and biochemical An explanatory syndrome of abnormal changes characterized by intestinal irritability. Clinically, it is often divided into diarrhea type, constipation type and diarrhea alternating type.

[0003] The prevalence of IBS has been reported differently in the literature. In developed countries such as the United Kingdom and the United States, it accounts for 20% to 30% of all age groups and 15% to 20% of the adult group. In western developed countries, female I...

Examples

Embodiment 1

[0045] Embodiment 1. Preparation of granules

[0046] prescription:

[0047] Radix Paeoniae Alba (fried) 66.7g Atractylodes macrocephala (fried) 40.0g Allium 40.0g Plantago 40.0g Bergamot 40.0g Peppermint oil 1.33ml

[0048] Process:

[0049] Soak the first 5 herbs in water for 1.5 hours, decoct twice, add 10 times the amount of water to extract for 2 hours for the first time, add 8 times the amount of water for 1.5 hours, filter, and concentrate the filtrate to relative density under reduced pressure It is a thick paste of 1.30-1.34 (60°C thermal measurement), dried under vacuum at 60°C (-0.08Mpa), crushed into fine powder, and set aside. Take another β-cyclodextrin that is 8 times the amount of peppermint oil in a mortar, add 4 times the amount of water and grind it evenly, then take peppermint oil (pre-prepared as 50% peppermint oil ethanol solution) and slowly add it into the mortar , ground for 3 hours, dried at 40°C, pulverized, and set aside. Take the above water-ex...

Embodiment 2

[0050] Embodiment 2. preparation pill (concentrated pill)

[0051] Radix Paeoniae Alba (fried) 65g Atractylodes macrocephala (fried) 35g Allium 35g Plantago 35g Bergamot 35g Peppermint oil 1ml.

[0052] Soak the first 5 herbs in water for 1 hour, decoct twice, add 10 times the amount of water to decoct for 2 hours for the first time, add 8 times the amount of water for 1.5 hours, filter, and concentrate the filtrate to relative density under reduced pressure It is 1.30~1.34 (60 ℃ thermal measurement) thick paste, vacuum dried at 60 ℃ (-0.08Mpa), crushed into fine powder, and set aside: another β-cyclodextrin 8 times the amount of peppermint oil is placed in a mortar, Add 4 times the amount of water and grind evenly, then take peppermint oil (pre-prepared as 50% peppermint oil ethanol solution) and slowly add it to the mortar, grind for 3 hours, dry at 40°C, crush, and set aside; take the above water to extract dry cream powder , add peppermint oil inclusion compound and appro...

Embodiment 3

[0053] Embodiment 3. preparation powder

[0054] Radix Paeoniae Alba (fried) 70g Atractylodes macrocephala (fried) 45g Allium 45g Plantago 45g Bergamot 45g Peppermint oil 2ml.

[0055] Soak the first 5 herbs in water for 2 hours, decoct twice, add 12 times the amount of water to extract for 2 hours for the first time, add 8 times the amount of water for 1.5 hours, filter, and concentrate the filtrate to relative density under reduced pressure It is 1.30~1.34 (60 ℃ thermal measurement) thick paste, vacuum dried at 60 ℃ (-0.08Mpa), crushed into fine powder, and set aside; another β-cyclodextrin 8 times the amount of peppermint oil is placed in a mortar, Add 4 times the amount of water and grind evenly, then take peppermint oil (pre-prepared as 50% peppermint oil ethanol solution) and slowly add it to the mortar, grind for 3 hours, dry at 40°C, crush, and set aside; take the above water to extract dry cream powder , add peppermint oil inclusion compound and appropriate amount of...

technical field

[0001] The invention relates to a pharmaceutical composition, preparation and preparation method for treating irritable bowel syndrome, belonging to the field of traditional Chinese medicine. Background technique

[0002] Irritable bowel syndrome (Irritable bowel syndrome, IBS) is a common digestive system functional disease, including a group of abdominal pain, bloating, abnormal bowel habits and stool characteristics, continuous or intermittent episodes, and lack of obvious morphological and biochemical An explanatory syndrome of abnormal changes characterized by intestinal irritability. Clinically, it is often divided into diarrhea type, constipation type and diarrhea alternating type.

[0003] The prevalence of IBS has been reported differently in the literature. In developed countries such as the United Kingdom and the United States, it accounts for 20% to 30% of all age groups and 15% to 20% of the adult group. In western developed countries, female I...

Examples

Embodiment 1

[0045] Embodiment 1. Preparation of granules

[0046] prescription:

[0047] Radix Paeoniae Alba (fried) 66.7g Atractylodes macrocephala (fried) 40.0g Allium 40.0g Plantago 40.0g Bergamot 40.0g Peppermint oil 1.33ml

[0048] Process:

[0049] Soak the first 5 herbs in water for 1.5 hours, decoct twice, add 10 times the amount of water to extract for 2 hours for the first time, add 8 times the amount of water for 1.5 hours, filter, and concentrate the filtrate to relative density under reduced pressure It is a thick paste of 1.30-1.34 (60°C thermal measurement), dried under vacuum at 60°C (-0.08Mpa), crushed into fine powder, and set aside. Take another β-cyclodextrin that is 8 times the amount of peppermint oil in a mortar, add 4 times the amount of water and grind it evenly, then take peppermint oil (pre-prepared as 50% peppermint oil ethanol solution) and slowly add it into the mortar , ground for 3 hours, dried at 40°C, pulverized, and set aside. Take the above water-ex...

Embodiment 2

[0050] Embodiment 2. preparation pill (concentrated pill)

[0051] Radix Paeoniae Alba (fried) 65g Atractylodes macrocephala (fried) 35g Allium 35g Plantago 35g Bergamot 35g Peppermint oil 1ml.

[0052] Soak the first 5 herbs in water for 1 hour, decoct twice, add 10 times the amount of water to decoct for 2 hours for the first time, add 8 times the amount of water for 1.5 hours, filter, and concentrate the filtrate to relative density under reduced pressure It is 1.30~1.34 (60 ℃ thermal measurement) thick paste, vacuum dried at 60 ℃ (-0.08Mpa), crushed into fine powder, and set aside: another β-cyclodextrin 8 times the amount of peppermint oil is placed in a mortar, Add 4 times the amount of water and grind evenly, then take peppermint oil (pre-prepared as 50% peppermint oil ethanol solution) and slowly add it to the mortar, grind for 3 hours, dry at 40°C, crush, and set aside; take the above water to extract dry cream powder , add peppermint oil inclusion compound and appro...

Embodiment 3

[0053] Embodiment 3. preparation powder

[0054] Radix Paeoniae Alba (fried) 70g Atractylodes macrocephala (fried) 45g Allium 45g Plantago 45g Bergamot 45g Peppermint oil 2ml.

[0055] Soak the first 5 herbs in water for 2 hours, decoct twice, add 12 times the amount of water to extract for 2 hours for the first time, add 8 times the amount of water for 1.5 hours, filter, and concentrate the filtrate to relative density under reduced pressure It is 1.30~1.34 (60 ℃ thermal measurement) thick paste, vacuum dried at 60 ℃ (-0.08Mpa), crushed into fine powder, and set aside; another β-cyclodextrin 8 times the amount of peppermint oil is placed in a mortar, Add 4 times the amount of water and grind evenly, then take peppermint oil (pre-prepared as 50% peppermint oil ethanol solution) and slowly add it to the mortar, grind for 3 hours, dry at 40°C, crush, and set aside; take the above water to extract dry cream powder , add peppermint oil inclusion compound and appropriate amount of...