Nucleic acid film tape and kit for diagnosing alpha mediterranean anemia

A technology for thalassemia and nucleic acid membrane strips is applied in the field of diagnostic reagents for thalassemia, which can solve the problems of missed diagnosis, inability to detect alpha gene mutation, EB pollution, etc., and achieve the effect of reducing economic burden, family burden and social cost.
CN101092647AActive Publication Date: 2007-12-26亚能生物技术(深圳)有限公司
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
亚能生物技术(深圳)有限公司
Publication Date
2007-12-26

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Abstract

This invention relates to test kit and test paper with oligonucleotide probes for diagnosing alpha-thalassemia. The test paper comprises a base, and specific oligonucleotide probes immobilized on the base. The oligonucleotide probes comprise: specific oligonucleotide probes for detecting mutation of alpha-globin gene, specific oligonucleotide probes for detecting deletion of alpha-globin gene, and base sequence complementary with the above sequences. The test kit comprises specific primer for amplifying alpha-globin gene or transcript, and specific oligonucleotide probes for detecting mutation / deletion of alpha-globin gene. The test kit and the test paper have such advantages as low cost, rapid detection, and stable results. The test kit and the test paper can be used in detection of mutation / deletion of alpha-globin gene, and prenatal diagnosis of severe thalassemia (alphaTalpha) caused by point mutation, and do not have error diagnosis.
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Description

technical field

[0001] The invention relates to a diagnostic reagent for thalassemia, in particular to a nucleic acid membrane strip and a kit for diagnosing α-thalassemia. Background technique

[0002] Thalassemia (thalassemia, hereinafter referred to as thalassemia) is due to the decrease in the synthesis rate of one or some globin chains in the patient, resulting in the lack of some peptide chains and the relative excess of other peptide chains, resulting in an imbalance in the number of peptide chains, resulting in hemolysis sexual anemia. There are two main types of thalassemia, α-thalassemia caused by a deficiency of α-globin chain synthesis and β-thalassemia caused by a deficiency of β-globin synthesis.

[0003] Alpha-thalassemia is one of the most common monogenic genetic diseases in the world. The disease occurs in a wide range from Italy, Greece, Malta, Cyprus along the Mediterranean Sea to Southeast Asian countries. Guangxi, Guangdong, Hainan, Hong Kong, Taiwan...

Claims

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