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Eplerenone liquid capsule preparations and method for preparing the same

A technology of eplerenone and liquid capsules, which is applied in the field of eplerenone liquid capsule preparations and preparations, can solve the problems of low bioavailability, and achieve crystal clear appearance, accurate content, and beautiful appearance

Inactive Publication Date: 2008-02-06
李林
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main disadvantage of tablets and capsules is that the bioavailability is not high. The tablets are ordinary tablets, 25mg per tablet, 50mg a day

Method used

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  • Eplerenone liquid capsule preparations and method for preparing the same
  • Eplerenone liquid capsule preparations and method for preparing the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Accurately weigh 87.5g of eplerenone, add it to 875g of polyethylene glycol 400, heat until the eplerenone dissolves, mix well to obtain a medicinal solution, add the aforementioned medicinal solution into the storage tank of the liquid capsule machine, Keep warm at 50°C to 60°C, adjust the filling volume, separate the cap body of the hard capsule, carry out quantitative filling, fit and seal, and seal to prepare 3500 liquid capsules.

Embodiment 2

[0032] Precisely weigh 175g of eplerenone, add it to the mixed solution of 1000g vegetable oil and 750g Tween 80, heat until the eplerenone dissolves, mix well to obtain the medicinal solution, add the above medicinal solution to the storage tank of the liquid capsule machine Inside, keep warm at 50°C to 60°C, adjust the filling volume, separate the cap body of the hard capsule, carry out quantitative filling, fit and seal, and seal to prepare 3500 liquid capsules.

Embodiment 3

[0034] Accurately weigh 350g of eplerenone, add it to the mixed solution of 3000g Tween 80 and 500g isopropanol, heat until the eplerenone dissolves, mix well to obtain a medicinal solution, add the aforementioned medicinal solution to the storage tank of the liquid capsule machine In the material tank, keep warm at 50°C to 60°C, adjust the filling volume, separate the cap body of the hard capsule, carry out quantitative filling, fit and seal, and seal to prepare 3500 liquid capsules.

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Abstract

The invention relates to eplerenone liquid capsule preparation and the preparation method thereof, which solves the problems of poor stability and low bioavailability of the prior eplerenone preparation. The contents liquid medicine of each hard capsule of the eplerenone liquid capsule preparation comprises raw material of following weight account: 25 mg to 100 mg eplerenone, 250 mg to 1000 mg organic solvent and 0 mg to 0.005 mg preservative. The eplerenone liquid capsule preparation has high bioavailability, good sealing performance, accurate content, crystal-clear and aesthetic appearance, perfect heat and wet resisting property, high toughness and ideal stability. The preparation method abandons a plurality of preparation procedures before filling ordinary capsules as well as necessary equipment and process adopting during soft capsule production such as glue digestion, pressing and drying, thereby reducing the production cost.

Description

technical field [0001] The invention relates to an eplerenone preparation, specifically an eplerenone liquid capsule preparation and a preparation method. Background technique [0002] The drug name of eplerenone described in the present invention is: [0003] Generic name: eplerenone [0004] English name: Eplerenone [0005] Chinese Pinyin: Yipulitong [0006] Chemical name: 9α, 11-epoxy-7α-(methoxyacyl)-3-oxo-17α-pregna-4-ene-21,17-carbonylactone Structural formula: [0007] [0008] Molecular formula: C 24 h 30 o 6 [0009] Molecular weight: 414.49 [0010] In recent years, the incidence of hypertension has increased year by year, and it is about 20% in some countries in Europe and America. Hypertension is the most important pathogenic factor of coronary heart disease, sudden onset, heart failure, and renal failure, and it is closely related to glucose and lipid metabolism disorders. Eplerenone can lower the blood pressure level of hypertensive people, and c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K9/66A61K31/585A61P9/12
Inventor 李林
Owner 李林
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