Microcapsule suspension type fluidized bed type bioreactor for artificial liver

A bioreactor and microcapsule suspension technology, applied in the field of biomedicine, can solve the problems of perfusion dead space, ineffective perfusion and marginal effect, affecting the effect of bioartificial liver support treatment, etc., achieving strong efficacy, avoiding perfusion dead space and ineffectiveness effect of perfusion

Active Publication Date: 2008-02-27
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the traditional bioartificial liver fluidized bed reactor adopts a column type, and there are perfusion dead space, even ine

Method used

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  • Microcapsule suspension type fluidized bed type bioreactor for artificial liver

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Embodiment Construction

[0015] The shape of the microcapsule suspension fluidized bed reactor for the artificial liver in this embodiment is funnel-shaped, with a plastic or plexiglass shell. During actual production, it can be enlarged or reduced according to needs, and the required size can be formulated.

[0016] As shown in Figure 1 and Figure 2: 1 is the blood / plasma / or culture solution inlet, for the blood / plasma / culture solution to enter the fluidized bed reactor container, and exchange substances with microencapsulated hepatocytes therein, 2 For blood / plasma / or culture solution outlet, 3 is the preflush / microencapsulated hepatocyte inlet, through which the liver cell suspension is injected and flushed into the preflush, 4 is the valve, closed after microencapsulated hepatocyte inoculation , 5 is a sampling port for sampling during artificial liver treatment, 6 is a valve for closing the sampling port, and 7 is a cell sieve with a bottom diameter of the funnel reactor, through which the liquid...

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Abstract

The invention discloses a microcapsule floating fluid-bed biological reactor of artificial liver in the medically biological technical domain, which is characterized by the following: displaying hopper shape with small bottom radius and large top radius; setting cell screen 8 at upper neck and cell screen 7 at lower bottom; depositing cell filter 8 at liquid outlet 2; setting buffer cavity 12 between liquid inlet 1 and cell screen 7, and between cell filter 11 and cell screen 8 respectively; containing the microcapsule liver cell 9 between cell screen 8 and cell screen 7; making the liquid inlet connect the membrane oxygenator 14 to connect immune adsorber 15 to adsorb immune macromolecule. The invention makes the moving trail of flow impaction as adjustment parabola to satisfy the character of fluid mechanics, which avoids dead perfusion cavity and ineffective perfusion to develop treating effect of biologically artificial liver obviously.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and relates to a medical device, a core device for biological or mixed biological artificial liver treatment-a microcapsule suspension fluidized bed bioreactor for artificial liver. Background technique [0002] Bioreactor is the core device of biological and hybrid artificial liver support systems. It is not only a place for material exchange between exogenous liver cells and patient blood or plasma, but also provides an ideal growth environment for liver cells. It is used as an artificial liver. Bioreactors generally meet the following basic requirements: bidirectional transmission of small and medium molecules, and immune barriers of macromolecules to ensure liver cell activity and a certain capacity. [0003] At present, hollow fiber bioreactors are the most widely used, but the disadvantages of hollow fiber bioreactors are uneven cell distribution and poor cell adhesion. In practical app...

Claims

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Application Information

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IPC IPC(8): A61F2/00A61B17/00A61M1/14C12M3/02
Inventor 李兰娟喻成波陈滟珊章益民杜维波
Owner ZHEJIANG UNIV
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