Method of preparing traditional Chinese medicine composition for treating coronary disease and quality control method thereof

A composition and technology of traditional Chinese medicine are applied in the fields of prevention and treatment of coronary heart disease, traditional Chinese medicine composition and preparation thereof, traditional Chinese medicine composition for angina pectoris and preparation and quality control thereof, and can solve the problems of difficulty in formulating quality standards and the like

Inactive Publication Date: 2008-02-27
吉林天药现代中药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Another important purpose of the present invention is to solve the problem that the traditional compound Chinese medicine quality standards are difficult to formulate.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0026] Experimental Example 1: Coronary Blood Flow Effect Experiment

[0027] Healthy Animals Adult mixed-breed dogs, both male and female, weighing 10.5-14.5kg.

[0028] Drugs and reagents The content of the test capsule (obtained by the preparation process of the present invention) was provided by the Pharmaceutical Research Center of Jilin Tianyao Technology Co., Ltd.; the positive control drug: Ginkgo biloba was provided by Guizhou Xinbang Pharmaceutical Co., Ltd.

[0029] Instruments CBI-8000 Doppler blood flow meter (USA); Powerlab / 8s eight-lead data analysis recorder (Australia); SC-3 artificial respirator (Shanghai); BI-2000 medical image analyzer (Chengdu ).

[0030] Experimental method Experimental animals were anesthetized with 3% pentobarbital sodium intravenously. Surgery, endotracheal intubation, connection to an artificial ventilator, separation of the left common carotid artery, intubation through a pressure transducer to record arterial blood pressure; sepa...

experiment example 2

[0035] Experimental example 2: The influence experiment of the ST segment of the epicardial electrocardiogram

[0036] Experimental animals, medicines and reagents, instruments and experimental methods are as in Experimental Example 1, recording canine epicardial electrocardiogram, and measuring the ST amplitude of electrocardiogram

[0037] Table 2 The effect of the test drug on the ST segment of the dog's epicardial electrocardiogram during myocardial ischemia

[0038]

group

control

Ginkgo biloba leaves

(24mg / kg)

Test drug

(24mg / kg)

Test drug

(12mg / kg)

Test drug

(6mg / kg)

Before administration

18.9±1.7

18.9±2.34

19.9±2.8

19.4±1.7

19.7±1.4

Knot

stick

rear

2'

10′

30′

1h

3 hours

190.8±24.3

258.8±50.3

231.1±23.7

240.7±28.1

159.4±51.6

135.3±31.9 **

...

experiment example 3

[0041] Experimental example 3: Effect experiment on the range of myocardial infarction

[0042] Myocardial infarction area measurement method At the end of Experiment 1, cut out the heart, wash it with normal saline, remove blood stains, remove blood vessel fat and other non-myocardial tissue, and cut the ventricle into a 1cm-thick myocardium along the atrioventricular groove from the apex to the base of the heart in parallel. Slice and wash with saline. Myocardium slices were placed in 0.025% nitro blue tetrazolium (NBT) solution and incubated in a water bath at 37°C for 15 minutes for staining. The normal myocardium was stained blue, but the infarcted myocardium was not stained. Through the video recording device of the BI-2000 medical image analysis system, the myocardial slices of each group are input into the computer in the form of pictures, and then the area of ​​the myocardial infarction and the whole myocardial area are determined and calculated by the software of t...

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PUM

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Abstract

The invention discloses a Chinese medicinal composition for treating coronary disease and angina pectoris, the process for preparing the medicament and the quality control method, wherein the Chinese medicinal composition comprises the raw materials of root of red rooted saliva 40-80 weight parts, pseudo-ginseng 30-70 weight parts, borneol 30-70 weight parts, albizia flower 200-300 weight parts, banksia rose 30-70 weight parts and liquidambar orientalis mill 8-15 parts.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition and a preparation method thereof, in particular to a traditional Chinese medicine composition for preventing and treating coronary heart disease and angina pectoris, its preparation and its quality control method, belonging to the field of traditional Chinese medicine. Background technique [0002] The so-called coronary heart disease and angina pectoris in modern Chinese medicine belong to the category of "chest pain" and "heartache" in traditional Chinese medicine. The location of the disease is in the heart, and the excess syndrome is mostly responsible for the liver and spleen, and the deficiency syndrome is mostly related to the heart and kidney. At present, there are many drugs for the treatment of coronary heart disease on the market, including chemical drugs and traditional Chinese medicines. Chemical drugs are effective in treating coronary heart disease, but they often cause ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61K9/48A61P9/10G01N30/02G01N30/90A61K31/045
Inventor 赵全成赫玉芳南敏伦
Owner 吉林天药现代中药科技有限公司
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