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Flavanone compound and uses thereof

A technology of flavanones and compounds, which is applied in the fields of flavanone compounds and their applications, and can solve problems such as unclear physiological activities of flavanone compounds

Inactive Publication Date: 2008-02-27
POKKA SAPPORO FOOD & BEVERAGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the physiological activity of these flavanone compounds is still unclear

Method used

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  • Flavanone compound and uses thereof
  • Flavanone compound and uses thereof
  • Flavanone compound and uses thereof

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Experimental program
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no. 1 approach

[0021] The flavanone compound according to the first embodiment is 5,7,3′,4′-tetrahydroxy-5′-C-geranylflavanone (isonymphaeol-B), represented by Structural Formula 1:

[0022]

[0023] The molecular formula of the flavanone compound is C 25 h 28 o 6 , with a molecular weight of 424 and a melting point of 123-126°C (see Figure 3). This flavanone compound is a naturally occurring novel compound, and was isolated from Okinawa propolis by the present inventors. Although the structural properties of this flavanone compound are similar to those of eriodictyol, it has a C-geranyl group at the 5'-position. Therefore, it is more lipophilic (or membrane permeable) than eriodictyol.

[0024] This flavanone compound has the same high antioxidant effect as eriodictyol or alpha-tocopherol. In addition, the flavanone compound has an anticancer effect, which can inhibit the proliferation of cancer cells such as breast cancer cells. In addition, the flavanone compound has the effect o...

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Abstract

Each of an antioxidant, an antimicrobial agent, an antitumor agent, a food and beverage product, cosmetics, a quasi-drug and a pharmaceutical of the present invention contains a new flavanone compound represented by the following structural formula: Alternatively, each of an antioxidant, an antimicrobial agent, an antitumor agent, a food and beverage product, cosmetics, a quasi-drug and a pharmaceutical of the present invention contains at least one flavanone compound selected from the group consisting of nymphaeol-A, nymphaeol-B, and nymphaeol-C.

Description

[0001] This application is a divisional application based on the following Chinese patent application: [0002] Date of original filing: June 18, 2004 [0003] Original application number: 200480017013.4 (PCT / JP2004 / 008964) [0004] Title of original application: Flavanone compounds and their applications technical field [0005] The present invention relates to a novel flavanone compound, and antioxidants, antibacterial agents, anticancer agents, food and drink, cosmetics, quasi-drugs and medicines each containing the flavanone compound. Background technique [0006] Known flavanone compounds include nymphaeol-A, nymphaeol-B and nymphaeol-C. For these known flavanone compounds see "K. Yakushijin, K. Shibayama, H. Murata and H. Furukawa: Neoprenyl flavanones from Hernandia Nymphaefolia (presl) Kubitzki, Journal of Heterocycles , Vol. 14, pp. 397-402, 1980", "W.R.Phillips, N.J.Baj, A.A.L. Gunatilaka and D.G.I. Kingston: C-geranyl compounds from Mimulus clevelandii, Journal...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D311/32A61K31/353A61K8/49A61P31/04A61P35/00A61P39/06A23L1/29C09K15/08A23L33/00
CPCY02A50/30
Inventor 熊泽茂则中山勉下位香代子后藤崇辉福本修一新垣勉
Owner POKKA SAPPORO FOOD & BEVERAGE