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Flavanone compound and uses thereof

A compound, flavanone technology, applied in the field of new flavanone compounds, can solve the problems such as unclear physiological activity of flavanone compounds

Inactive Publication Date: 2006-07-26
POKKA SAPPORO FOOD & BEVERAGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the physiological activity of these flavanone compounds is still unclear

Method used

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  • Flavanone compound and uses thereof
  • Flavanone compound and uses thereof
  • Flavanone compound and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

no. 1 approach

[0017] The flavanone compound according to the first embodiment is 5,7,3',4'-tetrahydroxy-5'-C-geranyl flavanone (isonymphaeol-B), represented by structural formula 1:

[0018]

[0019] The molecular formula of the flavanone compound is C 25 H 28 O 6 , The molecular weight is 424, and the melting point is 123-126°C (see Figure 3). The flavanone compound is a new naturally occurring compound and was isolated from Okinawa propolis by the present inventors. Although the structural properties of the flavanone compound are similar to those of eriochiol, it has a C-geranyl group at the 5'-position. Therefore, it has a higher lipophilicity (or membrane permeability) than holy grass.

[0020] The flavanone compound has the same high antioxidant effect as holy grass or α-tocopherol. In addition, the flavanone compound has an anticancer effect, which can inhibit the spread of cancer cells such as breast cancer cells. In addition, the flavanone compound has the effect of inducing physiolog...

no. 2 approach

[0055] The second embodiment has the following advantages.

[0056] Since any of nymphaeol-A, nymphaeol-B and nymphaeol-C have antioxidant, anticancer, and antibacterial effects, they can have a variety of uses, including food, beverages and drugs. In particular, although each of nymphaeol-A, nymphaeol-B and nymphaeol-C is a single compound, it can simultaneously exert multiple and multiple effects. Therefore, it is particularly noteworthy that each of nymphaeol-A, nymphaeol-B and nymphaeol-C can be used as a raw material for multifunctional health foods represented by propolis.

[0057]In addition, nymphaeol-A, nymphaeol-B and nymphaeol-C can also be used in applications similar to holy moth and various applications with higher lipophilicity than holy moth. Since nymphaeol-A, nymphaeol-B or nymphaeol-C are contained in propolis which is traditionally used as a raw material for health food, there is no problem in oral intake and transdermal intake.

[0058] The antioxidant accordi...

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Abstract

The present invention provides an antioxidant, antibacterial, antitumor agent, food or beverage, cosmetic, quasi-drug preparation, and medical product which each contains the novel flavanone compound represented by the following structural formula. Alternatively, the antioxidant, antibacterial, antitumor agent, food or beverage, cosmetic, quasi-drug preparation, and medical product each contains at least one flavanone compound selected among nymphaeol-A, nymphaeol-B, and nymphaeol-C. Structural formula (I).

Description

Technical field [0001] The present invention relates to a novel flavanone compound, and antioxidants, antibacterial agents, anticancer agents, food and beverages, cosmetics, quasi-drugs, and drugs each containing the flavanone compound. Background technique [0002] Known flavanone compounds include nymphaeol-A, nymphaeol-B and nymphaeol-C. For these known flavanone compounds, see "K. Yakushijin, K. Shibayama, H. Murata and H. Furukawa: Neoprenyl flavanones obtained by Hernandia Nymphaefolia (presl) Kubitzki, Heterocyclic Journal, Volume 14, pages 397-402, 1980", "WRPhillips, NJBaj, AALGunatilaka and DGI Kingston: C-geranyl compounds obtained from Mimulus clevelandii, Journal of Natural Products, Volume 59, pages 495-497, 1996", and "MHTseng, CHChou, YMChen and YHKuo: Prenylflavonoids from different species obtained from the fallen leaves of macaranga tanarius, Journal of Natural Products, Vol. 64, pages 827-828, 2001". Nymphaeol-A is isolated from H...

Claims

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Application Information

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IPC IPC(8): C07D311/32A61K31/353A61K8/49A61P31/04A61P35/00A61P39/06A23L1/29C09K15/08A23L33/00
CPCY02A50/30
Inventor 熊泽茂则中山勉下位香代子后藤崇辉福本修一新垣勉
Owner POKKA SAPPORO FOOD & BEVERAGE