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A preparation method of traditional Chinese medicine ligusticum wallichii injection

A technology for preparation of injections and injections, which is applied in the field of medicine, can solve the problems of hemolytic safety hazards, non-conformity with traditional Chinese medicine injections, etc., and achieve the effect of no hemolysis, maintaining natural characteristics, and simple methods

Inactive Publication Date: 2008-04-09
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the injection prepared directly from the above-mentioned Chuanxiong oil phase was found to have a safety hazard of hemolysis in animal experiments, so it did not meet the requirements of traditional Chinese medicine injections.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Example 1: Preparation of Chuanxiong Injection

[0014] 1. Preparation of raw materials: Wash the Chuanxiong with clean water, dry it at a low temperature of 30℃, and crush it to 20 mesh fine powder with a grinder;

[0015] 2. Extraction: Take 500g of Ligusticum chuanxiong powder and use a carbon dioxide extraction device (Nantong Huaan Supercritical Extractor, the same below) to extract the volatile oil. The extraction temperature is 20℃, the extraction pressure is 7.2MPa, and the extraction time is one and a half hours. 15ml.

[0016] 3. Preparation of injection: accurately weigh 2.5g of the oil obtained above, add 150ml of distilled water, perform steam distillation, collect the distillate to 50ml, add 0.3ml of Tween-80, add 0.4g of sodium chloride to make isotonic, stir well , Sub-packaging, disinfection, and then the traditional Chinese medicine Chuanxiong injection.

Embodiment 2

[0017] Example 2: Preparation of Chuanxiong Injection

[0018] 1. Preparation of raw materials: Wash the Chuanxiong with clean water, dry at a low temperature of 40℃, and crush to 20 mesh fine powder with a grinder;

[0019] 2. Extraction: Take 500g of Ligusticum chuanxiong powder and extract the volatile oil with a carbon dioxide extraction device. The extraction temperature is 25°C, the extraction pressure is 7.0MPa, and the extraction time is one and a half hours to obtain 14ml of volatile oil.

[0020] 3. Preparation of injection: accurately weigh 2g of the oil obtained above, add 150ml of distilled water, perform steam distillation, collect the distillate to 50ml, add 0.3ml of Tween-80, add 0.4g of sodium chloride to make isotonic, stir well , Divide into 10ml / piece with ampoules, sterilize with circulating steam at 100℃ for 30min, then the traditional Chinese medicine Chuanxiong injection is obtained.

Embodiment 3

[0021] Example 3: Preparation of Chuanxiong Injection

[0022] 1. Preparation of raw materials: Wash the Chuanxiong with clean water, dry it at a low temperature of 30℃, and crush it to 20 mesh fine powder with a grinder;

[0023] 2. Extraction: Take 500g of Ligusticum chuanxiong powder and extract the volatile oil with a carbon dioxide extraction device. The extraction temperature is 20°C, the extraction pressure is 7.5MPa, and the extraction time is two and a half hours to obtain 18ml of volatile oil.

[0024] 3. Preparation of injection: accurately weigh 2g of the oil obtained above, add 1500ml of distilled water, perform steam distillation, collect the distillate to 500ml, add 3ml of Tween-80, add 4g of sodium chloride to make isotonic, stir evenly, use The ampoules are divided into 10ml / piece and sterilized by circulating steam at 100°C for 30 minutes to obtain the traditional Chinese medicine Chuanxiong injection.

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PUM

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Abstract

The invention relates to a method for preparing Chinese medicine and chuanxiong rhizome injection. The method belongs to the medicine technical field, and comprises the steps that the chuanxiong rhizome is produced into fine powder, chuanxiong rhizome oil is extracted from the chuanxiong rhizome fine powder by adopting carbon dioxide, and the chuanxiong rhizome oil is used as the raw material to prepare the injection. The invention is characterized in that when the injection is prepared, the chuanxiong rhizome oil and distilled water are mixed in proportion of 1: 60 to 10000, steam distillation is performed until the distillate is one thirds of mother liquid, tween minus 80 is added into the distillate by 0.6 percent of the volume of the distillate, and sodium chloride is added by 0.8 percent of the volume of the distillate, isotonic blending, uniform stirring, separation and packaging, and disinfection are performed, and then the chuanxiong rhizome injection is obtained. The invention overcomes the hemolysis hidden safety danger existing in the direction preparation of the injection with the chuanxiong rhizome oil, and the reproducibility between one batch and another batch of the obtained chuanxiong rhizome injection can achieve the demand of the fingerprint of the Chinese medicine injection. The method of the invention is also suitable for preparing injection with other Chinese medicine taking volatile substances as effective components.

Description

Technical field [0001] The invention relates to the technical field of medicine, and is a new preparation method of traditional Chinese medicine Chuanxiong injection using volatile substances as effective ingredients. Background technique [0002] Due to batch-to-batch reproducibility problems, traditional Chinese medicine injections restrict their further promotion to the international market. The key to solving the reproducibility problem of traditional Chinese medicine injections is the source-the reproducibility of the raw materials. However, the natural particularity of traditional Chinese medicines The reproducibility of raw materials cannot be guaranteed due to differences in origin, harvest season, processing methods, etc., especially when traditional Chinese medicinal materials with volatile substances as effective ingredients, during the storage process, the volatile components are lost to varying degrees, making the preparation The batch-to-batch reproducibility of Chi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/236A61K9/08A61P25/06A61P29/00A61P9/10A61P9/12A61K125/00
Inventor 高丽红胡晋红
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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