Potassium muriate stomach-inner retention floationg type slow release tablet prepared with shuck powder as carrier

A technology of oyster shell powder and stomach retention, which is applied in the direction of active ingredients of alkaline/alkaline earth metal chlorides, medical preparations of non-active ingredients, drug delivery, etc. It can solve ulcers, calcium sources are difficult to absorb and utilize, and affect biological Utilization and other issues to achieve the effect of alleviating toxic effects

Inactive Publication Date: 2011-09-07
GUANGDONG OCEAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the calcium source existing in the natural state is difficult to be absorbed and utilized by the human body, and in recent years, people have cultivated and eaten oysters in large quantities, resulting in a large accumulation of oyster shells. How to comprehensively utilize oyster shells is a subject worth studying
In addition, potassium chloride is a potassium supplement commonly used clinically. Potassium ions have important physiological functions. Potassium deficiency in the body can lead to various diseases. Oral potassium supplementation is the main measure for the treatment of chronic potassium deficiency, but oral administration of ordinary tablets can cause irritation. Sexuality, can cause gastric and duodenal ulcers; oral administration of potassium chloride solution can also cause nausea, vomiting and loss of appetite, etc., thus affecting its bioavailability

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0025] 1) Weigh 10g potassium chloride and dissolve it in 20ml distilled water;

[0026] 2) Add 20 g of porous oyster shell powder activated by the above process to make the oyster shell powder fully absorb potassium chloride solution;

[0027] 3) Put the fully adsorbed oyster shell powder in an oven, and dry it by blasting at 50-60°C;

[0028] 4) Add 2g of sodium carboxymethylcellulose, 2g of mannitol, 1g of stearyl alcohol, and 2g of stearic acid, and mix thoroughly;

[0029] 5) It is obtained by dry pressing.

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PUM

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Abstract

The present invention is with oyster shuck powder as carrier to prepare potassium chloride stomach retention floating type slow release tablet, belonging to pharmaceutical preparation technique field. The technique is characterized in that its main components are oyster shuck powder and potassium chloride. The tablet can retain in stomach and prolong the medicine releasing time, improve the medicine absorption, be beneficial to promote bioavialability. The preparing technique process of the present invention is simple, convenient and reasonable operation, suitable for industrial production. And the price is achievement, using convenient, beneficial to large scale spreading and application. The medicine has calcium-replenishing function while treating hypokalemia, and relieved toxic effectof potassium ion to heart. The present invention has little dosage, good effect, and good market prospect.

Description

technical field [0001] The invention relates to a potassium chloride intragastric retention and floating slow-release tablet prepared by using oyster shell powder as a carrier, and belongs to the technical field of pharmaceutical preparations. Background technique [0002] Oyster shell (Concha Ostreae, OysterShell) is a commonly used traditional Chinese medicine, and its main components include light calcium carbonate, various amino acids and various trace elements, and the calcium content reaches 39.78%, which is a good biological calcium source. However, the calcium source in the natural state is difficult to be absorbed and utilized by the human body, and in recent years, people have cultivated and eaten oysters in large quantities, resulting in a large accumulation of oyster shells. How to comprehensively utilize oyster shells is a subject worth studying. In addition, potassium chloride is a potassium supplement commonly used clinically. Potassium ions have important phy...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/14A61K9/22A61K47/46A61P3/12A61P3/02
Inventor 宋文东黄洁静林宏图郭先霞
Owner GUANGDONG OCEAN UNIVERSITY
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