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Method for preparing schizandrin raw material

A technology of schisandrin and schisandra, applied in organic chemical methods, chemical instruments and methods, lignin derivatives, etc., can solve problems such as difficulty in adapting to large-scale dosage requirements, achieve low operating costs, high solvent recovery, and reduce loss effect

Inactive Publication Date: 2008-05-14
XIAN JIASHITE SCI & TECH
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  • Summary
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  • Description
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AI Technical Summary

Problems solved by technology

Although schisandrin has good clinical efficacy, the production capacity of existing production methods is difficult to meet the large-scale dosage requirements after clinical promotion

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Grind 100 grams of Schisandra fruit, then add No. 6 solvent oil for extraction, and extract at 35°C for 1.5 hours. The solvent is dehydrated with concentrated brine to remove impurities, and the solvent is concentrated at 90°C. The concentrated product can be used for refining rich Schisandra The total lignin extract of lignin is 12.2 grams.

Embodiment 2

[0020] 500 grams of schisandra fruits are crushed, then added with petroleum ether solvent, extracted at 45°C for 1.5 hours, the solvent is dehydrated with concentrated brine to remove impurities, concentrated at 85°C, and concentrated to obtain the total 69.4 grams of lignin extract.

Embodiment 3

[0022] 5 kg of schisandra fruits were crushed, then added with n-hexane solvent, extracted at 50°C for 1.5 hours, the solvent was dehydrated with concentrated brine to remove impurities, concentrated at 80°C, and concentrated to obtain the total schisandrin-rich compound 0.73 kg of lignin extract.

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PUM

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Abstract

The invention discloses a method for preparing the raw materials of schizadrin, which extracts the leach with the effective constituents of schisandra schizadrin by digesting the fruits of schisandra with solvent naphtha and gets the extract of all lignin rich in schizadrin by heating and distilling the enriched digestion solvent, which can be used to prepare high-purity schizadrin by further separation. Combined with prior mature complete extraction equipment, the invention can meet the demand of mass production by adopting the operation method of totally enclosed extraction. Since solvent naphtha is used as extraction solvent, the invention improves the solubility of solvent to lignin dramatically, reduces the consumption of extraction solvent considerably by utilizing prior mature equipment, increases the rate of extraction and output and cuts production cost. In addition, is the invention is environment-friendly, which can be used as a method for extracting the lignans compound of schisandra at large scale.

Description

technical field [0001] The invention relates to a preparation method of a raw material of schisandrin, which comprises extracting schisandrin fruit into an extract solution containing schisandrin, an effective component of schisandrin, and concentrating the extraction solvent by heating and distilling to obtain total lignin rich in schisandrin The extract can be used for further separation and preparation of high-purity schisandrin. Background technique [0002] Schisandra Chinesis (Turce.) Baill] is used as medicine, and it was first recorded in "Shen Nong's Materia Medica". Sweating and night sweating, nocturnal emission, chronic diarrhea, dysentery, insomnia, forgetfulness, and heart palpitations are one of the commonly used traditional Chinese medicines. Since the 1950s, a lot of research has been done on its resource status, chemical composition and pharmacological effects at home and abroad. In the early 1970s, clinical research in my country found that Schisandra ch...

Claims

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Application Information

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IPC IPC(8): C07G1/00C07C43/21C07B63/00C08H7/00
Inventor 周佳叶斌张立
Owner XIAN JIASHITE SCI & TECH
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