Prophylactic or therapeutic agent for conrneal/conjunctival disease

A therapeutic agent and technology for keratoconjunctivitis, applied in sensory diseases, aerosol delivery, medical preparations containing active ingredients, etc., can solve problems such as no suggestion, no discovery, etc.

Inactive Publication Date: 2008-06-18
坪田 一男 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] However, there is absolutely nothing described in any of the above-mentioned documents, nor does it imply
Moreover, it is difficult to infer the effect of selenoprotein P on eye diseases described in the present invention, and there is no report of this effect in fact.

Method used

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  • Prophylactic or therapeutic agent for conrneal/conjunctival disease

Examples

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Embodiment Construction

[0029] The selenoprotein P used in the present invention may be a natural product or a recombinant protein (for example, refer to JP-A-2004-337090), preferably human selenoprotein P. As described in the examples below, natural human selenoprotein P can be purified from human plasma. In addition, the selenoprotein P of the present invention may be full-length or may be a fragment containing a partial sequence thereof (for example, refer to International Patent Publication No. 00 / 31131 pamphlet).

[0030]As shown in the following examples, it was found that the selenoprotein P used in the present invention has an excellent therapeutic effect on the rat corneal epithelial disorder model. Therefore, medicines containing them are used as medicines for diseases accompanied by inflammation or defect of cornea or conjunctiva such as keratoconjunctival disease, more specifically, such as dry eye, keratoconjunctivitis sicca, epikeratosis punctate, corneal erosion or corneal ulcer, etc. ...

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Abstract

Disclosed is a novel composition for the treatment of a corneal / conjunctival disease. A prophylactic or therapeutic agent for a corneal / conjunctival disease comprising selenoprotein P as an active ingredient, more specifically a prophylactic or therapeutic agent for a corneal / conjunctival disease such as dry eye, keratoconjunctivitis sicca, punctate superficial keratitis, corneal erosion or corneal ulcer comprising selenoprotein P as an active ingredient, particularly a prophylactic or therapeutic agent for a corneal / conjunctival disease such as dry eye, keratoconjunctivitis sicca, punctate superficial keratitis, corneal erosion or corneal ulcer accompanied by a corneal and conjunctival epithelial disorder.

Description

technical field [0001] The present invention relates to a kind of selenoprotein P (Selenoprotein P) as the preventive or therapeutic agent of keratoconjunctival disease, especially relates to a kind of dry eye, keratoconjunctivitis sicca, punctate superficial keratosis, corneal erosion or A preventive or therapeutic agent for corneal ulcer or the like. Background technique [0002] Although the cornea is a thin, transparent tissue with a thickness of about 1mm and no blood vessels, it has a very regular fine structure consisting of epithelial layer, Bowman's membrane, parenchyma, Descemet's membrane, and endothelial cell layer. The cornea is located at the front of the eyeball. It is a highly differentiated tissue with permeability and refractive power used to transmit external light to the photoreceptors on the retina. It is very important for vision. It also has a barrier function against chemical attack or biological attack by microorganisms or the like. There is a tear...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/16A61K9/06A61K9/08A61P27/02
CPCA61K9/0048A61K38/1761A61P27/02A61P27/04A61K9/06A61K9/08A61K38/16
Inventor 渡边雅尚坪田一男平嶋正树野崎周英
Owner 坪田 一男
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