Pig replication and respiration syndrome virus attenuated vaccine strain and uses thereof

A technology for respiratory syndrome and attenuated vaccines, applied in the field of porcine reproductive and respiratory syndrome virus attenuated vaccine strains and attenuated vaccine strains, can solve the problems of poor vaccine pertinence, unsatisfactory immune effect, antigenic variation, etc., and achieve good safety Effect
CN101220348AActive Publication Date: 2008-07-16HARBIN VETERINARY RES INST CHINESE ACADEMY OF AGRI SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
HARBIN VETERINARY RES INST CHINESE ACADEMY OF AGRI SCI
Publication Date
2008-07-16

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Abstract

The invention discloses a porcine reproductive and respiratory syndrome virus attenuated vaccine strain, and the microorganism collection number is CGMCC NO.1883. The attenuated vaccine strain of the invention has stable genetic variation and good safety, which is safe and non-pathogenic for pregnant sows, piglets and the pigs at various ages. The immunized piglets after using the attenuated vaccine strain of the invention for immunization can resist the attack of the strong virus of the porcine reproductive and respiratory syndrome virus.
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Description

technical field

[0001] The invention relates to an attenuated vaccine strain, in particular to an attenuated vaccine strain of porcine reproductive and respiratory syndrome virus and its application, belonging to the field of biotechnology. Background technique

[0002] Porcine Reproductive and Respiratory Syndrome (Porcine Reproductive and Respiratory Syndrome, PRRS) is caused by PRRSV, characterized by reproductive disorders, respiratory symptoms, and highly contagious viral disease. The disease was first discovered in the United States in 1987. Wensvoort et al. isolated and identified the pathogen of the disease in 1991. PRRSV belongs to the Arterivirus genus of the family Arteriviridae (Arteriviridae), and is a positive-sense single-stranded RNA virus with an envelope. Since PRRSV has the characteristics of antigenic drift and variation, and its main target cells are alveolar macrophages (PAM), which have important immune functions, PRRSV infection is often accompanied b...

Claims

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