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Application of Sichuan chinaberry extract in pharmaceutical and extracting method thereof

An extraction method and the technology of toosendan, applied in the application of toosendan extract in pharmaceuticals and its extraction field, to achieve the effect of being suitable for popularization and application, and the extraction method is simple and easy

Inactive Publication Date: 2008-08-13
GUIZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Clinically, there is no safe, low-toxic and effective drug for the treatment of such diseases

Method used

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  • Application of Sichuan chinaberry extract in pharmaceutical and extracting method thereof
  • Application of Sichuan chinaberry extract in pharmaceutical and extracting method thereof
  • Application of Sichuan chinaberry extract in pharmaceutical and extracting method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1: Grind the dried Toosendan, pass through a 40-mesh sieve, weigh 150g, add 1000ml of 70% ethanol solution, soak 3 times at room temperature, each time for 72h, combine the soaking liquid, filter, and use 1 times the filtrate Chloroform extraction, the raffinate was concentrated under reduced pressure at 58°C to form a clear paste, then dissolved in 95% ethanol, filtered, and the filtrate was vacuum freeze-dried at about -80°C for 12 hours to obtain osteoclast-inhibiting Growth active extract.

[0021] The extract is added to a drug carrier, mixed, granulated and dried to obtain granules. For the treatment of bone loss diseases, such as osteoporosis, rheumatoid arthritis, multiple myeloma, Paget'S disease, osteolytic osteosarcoma, etc.

Embodiment 2

[0022] Example 2: crush the dried toosendan through a 40-mesh sieve, weigh 150g, add 10 times the amount of water, and extract it under reflux at 80°C for 6 times, each time for 2 hours, combine the extracts, filter, and use 0.5 times the amount of ethyl acetate for the filtrate Ester extraction, the raffinate is concentrated under reduced pressure into a thick paste, dissolved in 95% ethanol, filtered, and the filtrate is vacuum-freeze-dried at about -80°C for 12 hours after the solvent is recovered under reduced pressure. The obtained extract has a good ability to inhibit osteoclastosis Cell growth activity.

[0023] The extract is added to the drug carrier, mixed, granulated, dried and compressed into tablets to obtain tablets. For the treatment of bone loss diseases, such as osteoporosis, rheumatoid arthritis, multiple myeloma, Paget'S disease, osteolytic osteosarcoma, etc.

Embodiment 3

[0024] Example 3: crush the dried Toosendan through a 40-mesh sieve, weigh 150g, add 1000ml of 70% methanol aqueous solution, soak 6 times at room temperature, each time for 24h, combine the extracts, filter, and extract the filtrate with petroleum ether , the raffinate was concentrated into a thick paste under reduced pressure at 58°C, dissolved in methanol, filtered, and the filtrate was recovered from the solvent under reduced pressure, and then vacuum freeze-dried at about -80°C for 12 hours. The obtained extract had a good inhibitory effect on osteoclasts growth activity.

[0025] The extract is added to a drug carrier to make a capsule. For the treatment of bone loss diseases, such as osteoporosis, rheumatoid arthritis, multiple myeloma, Paget'S disease, osteolytic osteosarcoma, etc.

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Abstract

The invention provides an extractive which can inhibit the activities of osteoclast cells, the extract method and the application. The extractive is extracted from a fructus meliae toosendan, specifically, the fructus meliae toosendan is extracted by water or water-soluble organic solvents, so that an extracting solution is obtained and extracted by organic solvents, the residue of extracting is condensed by decompression, then dissolves in 60 to 100 percents of ethanol-water solution; the solution is filtered, the solvent of the filtrate is recycled and dried so as to get active extractive. The active extractive can be used to prepare a medicine for curing bone loss diseases. Compared with the prior art, the invention for the first time discloses a nature material which is extracted from the fructus meliae toosendan to inhibit the activities of osteoclast cells, the suppression ratio can is over 95 percents. The extract method provided by the invention is simple, and the extractive can be used to prepare the medicine for curing bone loss diseases, the invention also provides a new and effective choose for curing the diseases.

Description

technical field [0001] The invention relates to the application of Toosendan extract and its extraction method, in particular to the second use of Toosendan extract in pharmaceuticals and the extraction method of the Toosendan extract. Background technique [0002] Osteoporosis, rheumatoid arthritis, multiple myeloma, Paget'S disease, osteolytic osteosarcoma, etc. are diseases related to the physiological activity of osteoclasts, especially osteoporosis has seriously endangered global human health , especially endangering the health and quality of life of the elderly. Clinically, there is no safe, low-toxic and effective drug for the treatment of this type of disease. At present, the development of new drugs for the prevention and treatment of bone loss diseases such as osteoporosis from natural resources has gradually become a hot spot in research. [0003] Toosendan is the dry ripe fruit of Melia toosendan Sieb.et Zucc. Harvest when the fruit is ripe in winter, remove i...

Claims

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Application Information

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IPC IPC(8): A61K36/58A61P19/10A61P29/00A61P35/00A61P19/08A61K131/00
Inventor 周英郭东贵黄赤夫
Owner GUIZHOU UNIV
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