Application of Sichuan chinaberry extract in pharmaceutical and extracting method thereof

An extraction method and the technology of toosendan, applied in the application of toosendan extract in pharmaceuticals and its extraction field, to achieve the effect of being suitable for popularization and application, and the extraction method is simple and easy

Inactive Publication Date: 2008-08-13
GUIZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Clinically, there is no safe, low-toxic and ef

Method used

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  • Application of Sichuan chinaberry extract in pharmaceutical and extracting method thereof
  • Application of Sichuan chinaberry extract in pharmaceutical and extracting method thereof
  • Application of Sichuan chinaberry extract in pharmaceutical and extracting method thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0020] Example 1: Crush dried Neem Seeds, sieved through a 40-mesh sieve, weighed 150g, added 70% ethanol solution 1000ml, soaked 3 times at room temperature, 72h each time, combined the soaking liquid, filtered, and doubled the filtrate After extracting with chloroform by volume, the raffinate was concentrated under reduced pressure at 58℃ to form a clear cream, dissolved in 95% ethanol, filtered, and the filtrate was vacuum-freeze-dried at about -80℃ for 12h after the solvent was recovered under reduced pressure. Growth active extract.

[0021] The extract is added to the drug carrier, mixed, granulated, and dried to obtain granules. It is used to treat bone loss diseases, such as osteoporosis, rheumatoid arthritis, multiple myeloma, Paget’s disease, osteolytic osteosarcoma, etc.

Example Embodiment

[0022] Example 2: Crush the dried Neem Seeds through a 40-mesh sieve, weigh 150g, add 10 times the amount of water and reflux at 80°C for 6 times, 2h each time, combine the extracts, filter, and use 0.5 times the amount of ethyl acetate for the filtrate Ester extraction, the raffinate is concentrated under reduced pressure into a thick paste, dissolved in 95% ethanol, filtered, and the filtrate is vacuum-freeze-dried at about -80℃ for 12h after the solvent is recovered under reduced pressure. The obtained extract has a good inhibition of bone breaking Cell growth activity.

[0023] The extract is added to the drug carrier, mixed, granulated, dried, and compressed to obtain tablets. It is used to treat bone loss diseases, such as osteoporosis, rheumatoid arthritis, multiple myeloma, Paget’s disease, osteolytic osteosarcoma, etc.

Example Embodiment

[0024] Example 3: Crush the dried Neem Seeds through a 40-mesh sieve, weigh 150g, add 1000ml of 70% methanol aqueous solution, soak 6 times at room temperature for 24h each time, combine the extracts, filter, and extract the filtrate with petroleum ether The raffinate was concentrated under reduced pressure at 58°C into a thick paste, dissolved in methanol, filtered, and the filtrate was vacuum-freeze-dried for 12 hours after the solvent was recovered under reduced pressure. The resulting extract has a good inhibitory effect on osteoclasts. Growth activity.

[0025] The extract is added to the drug carrier to make a capsule. It is used to treat bone loss diseases, such as osteoporosis, rheumatoid arthritis, multiple myeloma, Paget’s disease, osteolytic osteosarcoma, etc.

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Abstract

The invention provides an extractive which can inhibit the activities of osteoclast cells, the extract method and the application. The extractive is extracted from a fructus meliae toosendan, specifically, the fructus meliae toosendan is extracted by water or water-soluble organic solvents, so that an extracting solution is obtained and extracted by organic solvents, the residue of extracting is condensed by decompression, then dissolves in 60 to 100 percents of ethanol-water solution; the solution is filtered, the solvent of the filtrate is recycled and dried so as to get active extractive. The active extractive can be used to prepare a medicine for curing bone loss diseases. Compared with the prior art, the invention for the first time discloses a nature material which is extracted from the fructus meliae toosendan to inhibit the activities of osteoclast cells, the suppression ratio can is over 95 percents. The extract method provided by the invention is simple, and the extractive can be used to prepare the medicine for curing bone loss diseases, the invention also provides a new and effective choose for curing the diseases.

Description

technical field [0001] The invention relates to the application of Toosendan extract and its extraction method, in particular to the second use of Toosendan extract in pharmaceuticals and the extraction method of the Toosendan extract. Background technique [0002] Osteoporosis, rheumatoid arthritis, multiple myeloma, Paget'S disease, osteolytic osteosarcoma, etc. are diseases related to the physiological activity of osteoclasts, especially osteoporosis has seriously endangered global human health , especially endangering the health and quality of life of the elderly. Clinically, there is no safe, low-toxic and effective drug for the treatment of this type of disease. At present, the development of new drugs for the prevention and treatment of bone loss diseases such as osteoporosis from natural resources has gradually become a hot spot in research. [0003] Toosendan is the dry ripe fruit of Melia toosendan Sieb.et Zucc. Harvest when the fruit is ripe in winter, remove i...

Claims

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Application Information

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IPC IPC(8): A61K36/58A61P19/10A61P29/00A61P35/00A61P19/08A61K131/00
Inventor 周英郭东贵黄赤夫
Owner GUIZHOU UNIV
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