Hypertension-treating medicine combination

A composition and technology of high blood pressure, applied in the field of medicine, can solve the problems of significant promotion of disease treatment, great differences in pathogenesis, and great differences in treatment methods, etc., to achieve increased treatment costs, increased treatment compliance, and prevention of Effects of drastic changes in blood pressure

Active Publication Date: 2010-12-15
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although hypertension, arrhythmia, angina pectoris and myocardial infarction etc. all belong to cardiovascular diseases, their pathogenesis is very different, and the corresponding treatment methods are also very different. However, this invention is only general and does not give any The specific composition technical scheme, the embodiment only relates to the preparation method of S-metoprolol, so it is not enough to bring significant impetus to the treatment of diseases

Method used

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  • Hypertension-treating medicine combination

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Experimental program
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Effect test

Embodiment 1

[0020] Embodiment 1 Hypertension compound tablet

[0021] S-Metoprolol Succinate 37.5g

[0022] Captopril 37.5g

[0023] Microcrystalline Cellulose 20g

[0024] Starch 15g

[0025] 15% starch slurry appropriate amount

[0026] Magnesium stearate 1.2g

[0027] Preparation process: It is prepared according to the conventional process of tablets.

Embodiment 2

[0028] Embodiment 2 hypertension compound tablet

[0029] S-Metoprolol Tartrate 105g

[0030] Perindopril 3g

[0031] Compressible starch 80g

[0032] Lactose 35g

[0033] 15% starch slurry appropriate amount

[0034] Micronized silica gel 1.5g

[0035] Preparation process: It is prepared according to the conventional process of tablets.

Embodiment 3

[0036] Embodiment 3 hypertension compound tablet

[0037] S-metoprolol tartrate 75g

[0038] Captopril 25g

[0039] Microcrystalline Cellulose 55

[0040] Starch 20g

[0041] 15% starch slurry appropriate amount

[0042] Magnesium stearate 1.2g

[0043] Preparation process: It is prepared according to the conventional process of tablets.

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Abstract

The invention provides a new pharmaceutical composition for treating hypertension, and relates particularly to a composition comprising S-metoprolol and angiotensin converting enzyme inhibitor including enalapril, captopril, lisinopril, perindopril, benazepril and fosinopril, wherein the weight ratio of S-metoprolol to angiotensin converting enzyme inhibitor is (1-35):1, preferably (3-25):1, morepreferably (7.5-18):1. The inventive composition is very important for long-term survival rate of hypertensive patients, and has a positive impact on the prognosis of hypertension for patients.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating hypertension, which belongs to the field of medicine. Background technique [0002] Metoprolol (metoprolol) is an aminopropanol drug, a selective β1 receptor blocker, and is the drug of choice for the treatment of hypertension in the world in recent years. It competes with excitatory epinephrine and norepinephrine, and protects the heart at the receptor's site, inhibits cardiac contractility, prevents hyperexcitability, and blocks nerve impulses. It also ensures the contraction of the smooth muscle of the heart wall by itself. The chemical name of metoprolol is: 1-4[(2-methoxyethyl)phenoxy]-3[(1-methoxyethyl)amino]-2propanol, and its structural formula is: [0003] [0004] Clinically, its hydrochloride, succinate, and tartrate are mainly used. [0005] Metoprolol is a chiral molecule with 1 chiral carbon atom and is a racemate of the R+ and S-enantiomers, the S-enantiomer being p...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/138A61K45/06A61K31/404A61K31/401A61K31/675A61P9/12
Inventor 赵志全
Owner LUNAN PHARMA GROUP CORPORATION
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