Nisoldipine sustained-release dropping pill and preparation method thereof

Abstract

The invention belongs to the field of sustained-release drugs, particularly relates to a nisoldipine sustained-release dropping pill and the preparation method thereof, and aims to supplement the deficiency of the prior art and provide a sustained-release nisoldipine dropping pill formulation. The sustained-release nisoldipine dropping pill is prepared by adding stabilize Vitamin E and hydrophobic framework ingredients to guarantee no occurrence of an obvious change related to the substance content for the drug during the effective storage period and has the advantages of full release, controllable release time and high bioavailability simultaneously. The sustained-release nisoldipine dropping pill is suitable for clinical and family use.

Description

Technical field [0001] The invention belongs to the field of sustained-release pharmacy, and in particular relates to a nisodipine sustained-release dripping pill and a preparation method thereof. technical background [0002] Cardiovascular and cerebrovascular disease is one of the diseases with the highest morbidity and mortality in the world today. It is the primary cause of death and the number one killer of health. The incidence of cardiovascular disease in my country is basically the same as that of the world, and it is increasing year by year. From the 7th cause of death in the 1960s to the 1st place, 3 million people die each year due to cardiovascular and cerebrovascular diseases, and 10 million are disabled due to cardiovascular and cerebrovascular diseases. Almost every cardio-cerebrovascular patient has clinical symptoms of elevated blood pressure and needs blood pressure lowering treatment. The market for blood pressure lowering drugs is huge. Nisodipine inhibits the...

AI Technical Summary

Problems solved by technology

[0003] Due to the preparation technology and other reasons, the oral preparations of most drugs, especially the oral preparations of traditional Chinese medicine, have long dissolution time, low dissolution rate, poor absorption, many times of taking medicine, uncontrollable drug release, and first pass through the liver and intestines after taking. Problems such as low efficacy and bioavailability, which affect the efficacy of the drug and directly affect the therapeutic effect

In addition, conventional oral dosage forms, such as tablets, capsules, granules (infusions), etc., due to the granulation process in the preparation process, will generate relatively large dust pollution, which will cause health problems to the staff to a certain extent. harm, and also cause some pollution to the environment

Furthermore, the production process of conventional oral preparations is complicated and the production cost is high, so that the cost of medication for patients is also increased, which is not conducive to improving the ability of patients to seek medical treatment, and is also not conducive to improving the overall health level of society.