Method of preparing low molecular weight colla carapaeis corii asini hydrolysate

Abstract

The invention relates to a preparation method of a low-molecular-weight colla corii asini hydrolyzate and belongs to the field of medical chemistry. The preparation method includes the following steps: firstly, pure colla corii asini without any auxiliary ingredients is adjusted to a system pH value between 5 and 9 under a constant temperature condition of 30 to 45 DEG C, and then enzyme is addedin to have a hydrolysis reaction for 1 to 2 hours; secondly, enzyme is killed through heating; thirdly, colla corii asini hydrolyzate is obtained after cooling or a powder product is obtained throughvacuum freeze drying; wherein, the enzyme is one, two or the compound of more than two of pepsin, trypsinase, papain, AS1.398 neutral protease and ficin. The preparation method of a low-molecular-weight colla corii asini hydrolyzate adopts pure colla corii asini as the ingredient and the generated product has high purity and is easier to be absorbed by the human body.

Description

Technical field: [0001] The invention belongs to the field of medicinal chemistry, in particular to a method for preparing low-molecular-weight donkey-hide gelatin hydrolyzate from donkey-hide gelatin without any auxiliary materials. Background technique: [0002] Donkey-hide gelatin, commonly known as donkey skin glue, is a black gelatin block made by boiling donkey skin with water after dehairing. The donkey-hide gelatin prepared by the traditional method has a molecular weight of tens of thousands, which is difficult for the human body to absorb and utilize, especially for patients in a disease state, because their own digestive function is weak, which affects the full play of the donkey-hide gelatin to a certain extent; in addition, in donkey-hide gelatin In the preparation process, in order to facilitate the final molding, some auxiliary materials are generally added to the donkey-hide gelatin. The final result of this is that the donkey-hide gelatin has a thicker visco...

AI Technical Summary

Problems solved by technology

However, although the above-mentioned patents have achieved certain results, the raw materials for their preparation all use finished donkey-hide gelatin products treated with auxiliary materials. When preparing hydrolyzed donkey-hide gelatin, these donkey-hide gelatin products need to be dissolved. Since they contain auxiliary materials, they are not conducive to the hydrolysis reaction.