Glucose-sensitive hydrogels

A hydrogel and gel technology, applied in the field of glucose-sensitive hydrogel, can solve the problem of fast insulin release

Inactive Publication Date: 2008-10-01
GENERAL HOSPITAL OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Kataota [8] The gels prepared by NIPAAm and phenylboronic acid are very sensitive to environmental glucose concentration. The insulin release experiment shows that there is no release when the glucose concentration is lower than 1g / l (5.55mM), but when the glucose concentration reaches 3g / l (16.67mM) , faster insulin release

Method used

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Experimental program
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Effect test

Embodiment 1

[0035] The preparation of embodiment 1 methacrylamidophenylboronic acid:

[0036] ◆3-Aminophenylboronic acid hemisulfate, PBA + ) 26.9 mmol was suspended in 20 ml of water, and adjusted to pH 5.0 with 1N NaOH solution (about 25 ml). The total volume of the solution is about 45ml.

[0037] ◆Dissolve 30mmol of Methacryl acid (MAA) in 20ml of 1N NaOH solution, and adjust the pH of the solution to 4.8 with 1N NaOH solution. The total volume of the solution is about 25ml.

[0038] ◆1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (1-ethyl-3-(3-dimethylaminopropyl)carbodiimide, EDAC) 30mmol dissolved in 10ml water, add 0.1N HCl to adjust the pH To 4.90, the total volume of the solution is about 15ml.

[0039] ◆Mix the above PBA+ suspension and EDAC solution, stir, put in an ice bath (2 , to maintain pH 4.9. After 30min, MAA solution was slowly added dropwise to the mixture under the same conditions, and the reaction mixture continued to flow through N 2 Ice bath for 1 hr.

[0040]...

Embodiment 2

[0042]The preparation of embodiment 2 gel:

[0043] Methacrylamidophenylboronic acid 0.2mM, dimethylaminopropyl methacrylamide (N, N-Dimethylaminopropyl methylacrylamide, DMAPMA) 0.8mM, EGDMA (Ethylene glycol dimethacrylate) 6.4μl, N, N, N', N '-Tetramethylethylenediamine (N,N,N',N'-tetramethylethylenediamine, TEMED) 2μl, dissolved in 1ml methanol: water (1:1), add 10% ammonium persulfate (Ammonium persulfate, APS) solution 30 μl, and put the mixture into a suitable container for molding (at room temperature for 12-24 hours).

[0044] The resulting gel structure:

[0045]

[0046] Example 3 Example 2 The swelling changes of the gel in glucose solution, different pH buffers and fructose solution

[0047] Example 2 The gel is sensitive to glucose, and the gel diameter is taken as the initial value (100%) to calculate the change rate of the gel diameter as the swelling rate when the glucose concentration is 0 under the same pH condition, and the swelling rate of the gel chan...

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Abstract

The invention relates to a glucose-sensitive hydrogel, a preparation method thereof and the application in an insulin delivery system and blood glucose dynamic monitoring; wherein, the glucose-sensitive hydrogel and the method are technically characterized by arbitrary arrangement and combination among A, B and C and the proportion between the A and the B.

Description

field of invention [0001] The present invention relates to glucose-sensitive hydrogel, its preparation method and its application in insulin delivery system and blood glucose dynamic monitoring. Background of the invention [0002] Hydrogel is a kind of environment-sensitive material. The change of certain stimuli signals in the external environment will cause the change of hydrogel structure, thereby changing the volume or sol-gel phase transition. Hydrogels sensitive to different signals have a very wide range of applications in the design of smart biomaterials, such as switches, sensors, mechanochemical triggers, special separation systems, bioreactors, etc. The self-adjusting drug delivery system refers to the drug delivery system that senses the physiological / pathological changes of the human body and responds to control the drug release. It is also a research hotspot for the new generation of drug delivery systems. There are mainly pH-sensitive, temperature-sensitive ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K47/24A61K38/28C07F5/02C08J3/075
Inventor 徐风华
Owner GENERAL HOSPITAL OF PLA
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