Biocompatible membrane and application thereof

A biocompatible membrane and biocompatibility technology, applied in the field of biosensors, can solve the problems of reducing accuracy, difficulty in simultaneous regulation, and shortening the service life of biocompatible membrane solutions.

Pending Publication Date: 2021-11-30
SUZHOU ZHONGXING MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
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Problems solved by technology

Although they can eliminate the interference of oxygen very effectively, it is difficult to achieve effective and precise simultaneous regulation of oxygen and glucose. To effectively regulate glucose, the thickness of the biocompatible membrane must be significantly increased.
Too thick a biocompatible film will directly lead to a long response time of the dynamic blood glucose meter to glucose, causing serious hysteresis and greatly reducing its accuracy.
In additi

Method used

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  • Biocompatible membrane and application thereof
  • Biocompatible membrane and application thereof
  • Biocompatible membrane and application thereof

Examples

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Embodiment Construction

[0028] The present invention will be further described with reference to the accompanying drawings.

[0029] like figure 1 As shown, the biocompatible membrane of the present invention is composed of three functional parts such as a skeleton, a hydrophilic group (glucose regulating group) and a biocompatible group.

[0030] The biocompatible film is prepared from a biocompatible film precursor, and the biocompatible film precursor includes the following components in parts by weight: 10-100 g of an organic skeleton compound, 5-50 g of an organic compound with a hydrophilic group, and a biophase 1-20g of organic compounds with capacitive groups; among them, organic skeleton compounds include aromatic olefin compounds or alkene ester compounds; organic compounds with hydrophilic groups include organic acid esters, alcohols, ethers with ethylene glycol groups , olefin or polyepoxide organic compounds; organic compounds with biocompatible groups include amino acids with vinyl or ...

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Abstract

The invention discloses a biocompatible membrane. The biocompatible membrane is composed of three functional parts, namely an organic framework compound, a hydrophilic group organic compound and a biocompatible group organic compound. The biocompatible membrane has high biocompatibility, fundamentally gets rid of the restriction of oxygen on glucose detection, improves the sensitivity, accuracy, reproducibility, stability, specificity and anti-interference capability of glucose dynamic detection, prolongs the service life of a continuous glucose monitoring system, and greatly reduces cost at the same time.

Description

technical field [0001] The present invention relates to the technical field of biosensors, more specifically, it relates to biocompatible films and applications thereof. Background technique [0002] As the only interface in direct contact with the living body of minimally invasive (implantable) monitoring systems (Dexcom G5 and G6 from Dekang, Abbott Diabetes Care FreeStyleLibre), the performance of the biocompatible film directly determines the biocompatibility of the minimally invasive monitoring system Performance, sensitivity, stability, anti-interference ability and working life during living body monitoring. This biocompatible membrane had to be bifunctional—in addition to being highly biocompatible, it had to be selectively permeable—that could efficiently regulate oxygen and glucose. Existing continuous glucose monitoring systems work on two different principles: (1) monitoring glucose indirectly by electrochemically detecting hydrogen peroxide generated during glu...

Claims

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Application Information

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IPC IPC(8): C09D201/00A61B5/145A61B5/1473
CPCC09D201/00A61B5/14532A61B5/1473
Inventor 沈薇
Owner SUZHOU ZHONGXING MEDICAL TECH CO LTD
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