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Composition for curing skin pruritus and preparation method thereof and quality control method

A quality control method and technology for skin pruritus, applied in skin diseases, drug combinations, medical preparations containing active ingredients, etc., can solve the problem of insignificant curative effect, and achieve stable pharmacological effects, good identification specificity, and good efficacy. Effect

Active Publication Date: 2008-10-01
BEIJING ASIA EAST BIO PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently on the market, there are few oral Chinese medicinal preparations for the treatment of skin pruritus, and most of them have insignificant curative effects, so it is necessary to provide a Chinese medicinal preparation with significant curative effect and exact

Method used

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  • Composition for curing skin pruritus and preparation method thereof and quality control method
  • Composition for curing skin pruritus and preparation method thereof and quality control method
  • Composition for curing skin pruritus and preparation method thereof and quality control method

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0049] Experimental Example 1 Pharmacological Test

[0050] Drug group I of the present invention Fructus Xanthii (stir-fried, pricked) 190g, Tribulus terrestris 180g, Rhizoma Chuanxiong 190g, peach kernel 180g, Baiying 100g;

[0051] Drug group II of the present invention Cocklebur (stir-fried, pricked) 290g Kochia chinensis 250g Chuanxiong 240g safflower 120g Baiying 70g

[0052] Drug group III of the present invention Cocklebur (stir-fried, pricked) 270g Kochia scoparia 220g Chuanxiong 250g safflower 130g Baiying 70g

[0053] Drug group IV of the present invention Cocklebur (stir-fried, pricked) 200g Kochia chinensis 200g Chuanxiong 200g Safflower 200g Baiying 100g

[0054] Positive control group Commercially available Xiaofeng Zhiyang Granules

[0055] According to the prescription of above four groups of medicine of the present invention, be prepared into granule, compare the antipruritic and blood promoting effect between each group, determine the reliability of the cu...

experiment example 2

[0069] Experimental example 2 content determination experiment

[0070] Through a large number of experimental studies, it is determined to adopt high performance liquid chromatography to measure the content of ferulic acid in the medicine of the present invention, so as to improve the quality detection method of the medicine of the present invention. Some test results are as follows:

[0071] 1. Preparation of the test solution

[0072] ① Selection of extraction solvent

[0073] Take an appropriate amount of the pharmaceutical composition granule of the present invention, grind it finely, accurately weigh about 3g respectively, put in a stoppered conical bottle, accurately add 25ml of methanol-formic acid mixed solution in different mixing ratios, weigh, and ultrasonically process (power 250W, frequency 40KHZ) for 30 minutes, let it cool, make up the lost weight, compare the content of ferulic acid in different proportions of solvents after extraction for the same time, the...

experiment example 3

[0100] Experimental example 3 Identification experiment

[0101] 1) TLC identification of Rhizoma Chuanxiong

[0102] ① Preparation of the test solution

[0103] a, the selection of extraction solvent gets 18g altogether 4 parts of pharmaceutical granule of the present invention, respectively adds 50% ethanol, 75% ethanol, 95% ethanol, each 50ml of absolute ethanol, ultrasonic treatment 30 minutes, filter, filtrate evaporates to dryness, residue adds Dissolve in 2ml of absolute ethanol as the test solution. Compare different test product solutions on the fluorescent spot color development effect on the thin-layer plate, the results are shown in the following table:

[0104] extraction solvent

50% ethanol

75% ethanol

95% ethanol

Absolute ethanol

Color effect

spot color effect

The fruit is very poor, there is

interference

spot color effect

poor fruit, dry

disturb

spot color effect

poor, disturbing

...

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PUM

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Abstract

The invention discloses a pharmaceutical composition for treating skin pruritus, a preparation method and a quality control method thereof. The pharmaceutical composition of the invention consists of crude drugs as follows: fruit of Siberian cocklebur, puncture vine fruit, rhizoma ligustici wallichii, peach kernel and herb of bittersweet. The preparation method is characterized in that: water is added for decoction for 2 to 3 times and 1 to 3 hours for each time, decoction solution is mixed and kept standing for 7 to 9 hours for sedimentation, and supernatant fluid is taken and condensed into clear paste, the relative density of which is 1.36 (65 to 75 DEG C); one portion of the clear paste is taken, three portions of cane sugar powder, one portion of dextrin and a proper amount of ethanol are added to prepare granules which are dried and the pharmaceutical composition is prepared. High performance liquid chromatography is used for determining the content of forulic acid by the invention. The pharmaceutical composition of the invention has very good curing effect for skin pruritus.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, a preparation method and a quality control method thereof, in particular to a traditional Chinese medicine composition for treating skin pruritus, a preparation method and a quality control method thereof. Background technique [0002] Skin itching is a clinical symptom of various skin diseases, mainly manifested as skin itching, macules, papules, and even exudation and blisters. Skin hypertrophy and lichenoid changes may appear in the chronic phase. There are many reasons for skin itching, such as infection, food or drug allergy, gastrointestinal heat accumulation, indigestion, endocrine disorders, and multi-system diseases. [0003] To treat pruritus, we should first clarify what is the cause of itching, avoid and eliminate the cause, and then treat the symptoms to have a good effect. Currently, Western medicine antihistamines, calcium agents and hormones are commonly used in the t...

Claims

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Application Information

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IPC IPC(8): A61K36/81A61K9/16A61P17/04G01N30/90G01N30/02
Inventor 付立家付建家
Owner BEIJING ASIA EAST BIO PHARMA CO LTD
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