Composition for curing skin pruritus and preparation method thereof and quality control method

A quality control method and technology for skin pruritus, applied in skin diseases, drug combinations, medical preparations containing active ingredients, etc., can solve the problem of insignificant curative effect, and achieve stable pharmacological effects, good identification specificity, and good efficacy. Effect

Active Publication Date: 2008-10-01
BEIJING ASIA EAST BIO PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently on the market, there are few oral Chinese medicinal preparations for the treatment of skin pruritus, and most of them have i

Method used

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  • Composition for curing skin pruritus and preparation method thereof and quality control method
  • Composition for curing skin pruritus and preparation method thereof and quality control method
  • Composition for curing skin pruritus and preparation method thereof and quality control method

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0049] Experimental example 1 Pharmacological test

[0050] Drug group I of the present invention: Xanthium (stir-fried, de-thorn) 190g Tribulus terrestris 180g Ligusticum chuanxiong 190g Peach kernel 180g Baiying 100g;

[0051] The drug group II of the present invention Xanthium (stir-fried, de-thorn) 290g Kochia scoparia 250g Chuanxiong 240g Safflower 120g Baiying 70g

[0052] Pharmaceutical Group III of the present invention Xanthium (stir-fried, de-thorn) 270g Kochia scoparia 220g Chuanxiong 250g Safflower 130g Baiying 70g

[0053] Drug group IV of the present invention Xanthium (fried, de-thorn) 200g Kochia scoparia 200g Ligusticum chuanxiong 200g Safflower 200g Baiying 100g

[0054] Positive control group Commercial Xiaofengzhiyang Granules

[0055] According to the prescriptions of the above four groups of the medicines of the present invention, granules are prepared, and the antipruritic and blood activating effects of each group are compared to determine the reliability o...

Example Embodiment

[0069] Experimental example 2 content determination experiment

[0070] After a large number of experimental studies, it is determined that the HPLC method is used to determine the content of ferulic acid in the drug of the present invention, so as to improve the quality detection method of the drug of the present invention. Some test results are as follows:

[0071] 1. Preparation of test solution

[0072] ①Optimization of extraction solvent

[0073] Take an appropriate amount of the granules of the pharmaceutical composition of the present invention, grind them, and accurately weigh about 3g respectively, place them in a cone-shaped bottle with a stopper, and accurately add 25ml of methanol-formic acid mixed solution of different mixing ratios, weigh it, and ultrasonic treatment (power 250W, frequency 40KHZ) 30 minutes, let it cool to make up for the weight lost, compare the content of ferulic acid after the same time of extraction with different proportions of solvents, the res...

Example Embodiment

[0100] Experimental example 3 Identification experiment

[0101] 1) TLC identification of Chuanxiong

[0102] ① Preparation of test solution

[0103] a. Selection of extraction solvent Take 18g of the pharmaceutical granules of the present invention in 4 parts, add 50% ethanol, 75% ethanol, 95% ethanol, and 50ml each of absolute ethanol, ultrasonically treat for 30 minutes, filter, evaporate the filtrate, and add the residue Dissolve in 2ml of absolute ethanol as the test solution. Compare the color development effects of fluorescent spots on the thin-layer plate with different test solution solutions, and the results are shown in the following table:

[0104] Extraction solvent

[0105] b. Selection of extraction time Take 18g of the drug granules of the present invention in 4 parts, add 50ml each of anhydrous ethanol, sonicate for 10, 20, 30, 40 minutes, filter, evaporate the filtrate to dryness, and dissolve the residue with 2ml of anhydrous ethanol, as Test solution. C...

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Abstract

The invention discloses a pharmaceutical composition for treating skin pruritus, a preparation method and a quality control method thereof. The pharmaceutical composition of the invention consists of crude drugs as follows: fruit of Siberian cocklebur, puncture vine fruit, rhizoma ligustici wallichii, peach kernel and herb of bittersweet. The preparation method is characterized in that: water is added for decoction for 2 to 3 times and 1 to 3 hours for each time, decoction solution is mixed and kept standing for 7 to 9 hours for sedimentation, and supernatant fluid is taken and condensed into clear paste, the relative density of which is 1.36 (65 to 75 DEG C); one portion of the clear paste is taken, three portions of cane sugar powder, one portion of dextrin and a proper amount of ethanol are added to prepare granules which are dried and the pharmaceutical composition is prepared. High performance liquid chromatography is used for determining the content of forulic acid by the invention. The pharmaceutical composition of the invention has very good curing effect for skin pruritus.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, a preparation method and a quality control method thereof, in particular to a traditional Chinese medicine composition for treating skin pruritus, a preparation method and a quality control method thereof. Background technique [0002] Skin itching is a clinical symptom of various skin diseases, mainly manifested as skin itching, macules, papules, and even exudation and blisters. Skin hypertrophy and lichenoid changes may appear in the chronic phase. There are many reasons for skin itching, such as infection, food or drug allergy, gastrointestinal heat accumulation, indigestion, endocrine disorders, and multi-system diseases. [0003] To treat pruritus, we should first clarify what is the cause of itching, avoid and eliminate the cause, and then treat the symptoms to have a good effect. Currently, Western medicine antihistamines, calcium agents and hormones are commonly used in the t...

Claims

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Application Information

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IPC IPC(8): A61K36/81A61K9/16A61P17/04G01N30/90G01N30/02
Inventor 付立家付建家
Owner BEIJING ASIA EAST BIO PHARMA CO LTD
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