Method for quantitative analyzing RNA mutation harmfulness
A quantitative analysis and harmfulness technology, applied in the field of computer programs, can solve the problems of analyzing and predicting RNA harmful mutations, difficult quantification, and difficult assessment of mutational harmfulness
Inactive Publication Date: 2011-02-02
INST OF RADIATION MEDICINE ACAD OF MILITARY MEDICAL SCI OF THE PLA
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[0004] The purpose of the present invention is to provide a quantitative method for analyzing the harmfulness of RNA mutations simply, conveniently and quickly, to solve the problems of difficult evaluation, quantification and analysis of the harmfulness of mutations, and to achieve the purpose of analyzing and predicting the harmfulness of RNA mutations. To improve the understanding of RNA mutation and even RNA evolution
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[0042] figure 1 It is an overall frame diagram for quantitatively analyzing the harmfulness of RNA mutations in the present invention.
[0043] First, in a method for quantitatively analyzing the harmfulness of RNA mutations, the harmfulness of the site structure of RNA mutations is calculated, and the specific steps are as follows: check the legitimacy of the RNA sequence input from the computer terminal, mutate it to generate mutants, RNA Folding, comparing the distance of the overall structure between the input RNA sequence and its mutants, and calculating the structural deleteriousness of the site.
[0044] figure 2 for figure 1Flowchart for calculation of midpoint structural deleteriousness.
[0045] For the RNA sequence input from the computer terminal, the legality check is performed according to the definition of the RNA sequence. The RNA sequence is a string R=r taken from the alphabet A={A,C,G,U} 1 , r 2 ,...,r n , where r i ∈A, i=1, 2, . . . , n. For input...
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The invention relates to a computer program, more specifically to a method for quantitatively analyzing RNA mutation harmfulness. The invention aims to provide a quantitative method capable of analyzing RNA mutation harmfulness simply, conveniently and quickly, solves the problem that mutation harmfulness is difficult to evaluate, quantify and analyze, reaches the objectives of analysis and prediction of RNA mutation harmfulness, thus improving the understanding of RNA mutation and RNA evolution. The invention provides a method for quantitatively analyzing RNA mutation harmfulness for a computer system, which fuses site structure harmfulness information with site sequence harmfulness information, quantitatively analyzes RNA mutation harmfulness, and gives a quantitative analyzing result of RNA mutation harmfulness.
Description
technical field [0001] The present invention relates to a computer program, more specifically, a method for quantitatively analyzing the deleteriousness of RNA mutations. Background technique [0002] As a biological macromolecule carrying important functions, base mutations in RNA may lead to pathological phenotypic changes. Studies have shown that mutations in some RNA regulators are associated with neuropsychiatric disorders; mutations in tRNAs in mitochondria harbor more than half of the known pathogenic mutations in mitochondria; recent studies have also shown that mutations in miRNA genes and their flanking sequences may cause cancer . On the other hand, RNA mutations can be "beneficial" in certain circumstances. Studies have found that the distribution of recombinant ribose functional sites and antibiotic active sites is related to the sites of rRNA mutations in known bacteria; Yassin et al. proved that rRNA mutations in bacteria can be used as markers of highly eff...
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IPC IPC(8): G06F19/00G16B10/00
Inventor 王升启舒文杰伯晓晨
Owner INST OF RADIATION MEDICINE ACAD OF MILITARY MEDICAL SCI OF THE PLA