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Ji Chuan Jian oral preparation and preparation method thereof

A technology for oral preparations and prescriptions, which can be used in pill delivery, pharmaceutical formulations, medical preparations with non-active ingredients, etc. It can solve problems such as inaccurate dosage, large dosage of traditional Chinese medicine decoctions, and inability to commercialize

Inactive Publication Date: 2008-10-15
苏州世林医药技术发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The ancient Jichuan decoction did not only have decoctions, but it needs to be decocted and taken after purchasing decoction pieces. It is very inconvenient to carry and take it. After research, we made modern oral preparations of traditional Chinese medicine through quantitative control of index components. The product dosage is accurate, the quality is stable, and it is convenient. It is suitable for large-scale commercial production, and overcomes the shortcomings of traditional Chinese medicine decoctions such as large dosage, inaccurate dosage, inconvenient carrying and taking, and inability to commercialize, and is convenient for clinical treatment and home use.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Example 1: Preparation method of Jichuan decoction extract

[0038] Prescription: Angelica 9-15 parts, Achyranthes bidentata 6 parts, Cistanche 6-9 parts, Alisma 5 parts, Cimicifuga 1.5-3 parts, Citrus aurantii 3 parts.

[0039] Preparation method: cleanly select the medicinal materials of the prescription, weigh each medicinal material according to the prescription amount, add 8 to 12 times the amount of water to soak for 2-4 hours, heat and boil for 2-3 times, and combine the extracts; the water extracts stand still After 12-48 hours, filter the supernatant, concentrate under reduced pressure to obtain extract or spray dry to obtain about 8.0 g of water extract.

Embodiment 2

[0040] Example 2: Preparation method of Jichuan decoction oral solid preparation

[0041] (1) Preparation of Jichuan decoction granules

[0042] prescription:

[0043]Ji Chuan Jian Extract 10-90%

[0044] Starch 5.0-70%

[0045] Dextrin 2.0-20%

[0046] Xylitol 5.0-20%

[0047] Methyl sorbate 0.001-2.0%

[0048] Preferred Prescription:

[0049] Ji Chuan Jian Extract 8.0g

[0050] Starch 3.0g

[0051] Dextrin 3.0g

[0052] Xylitol 2.0g

[0053] Methyl sorbate 0.002g

[0054] Preparation method: prepare Chaiji Chuanjian extract according to the method in Example 1, add prescription amount of excipients to make granules according to conventional methods, and pack them.

[0055] (2) Preparation of Jichuan decoction tablets:

[0056] (1) Ordinary tablet prescription:

[0057] Ji Chuan Jian Extract 5.0-90%

[0058] Starch 5.0-50%

[0059] Dextrin 2.0-20%

[0060] Microcrystalline Cellulose 5.0-20%

[0061] Talc 0.5-5.0%

[0062] Magnesium stearate 0.1-5.0%

[00...

Embodiment 3

[0139] Example 3: Preparation method of Jichuanjian oral liquid preparation

[0140] Prescription: Ji Chuan Jian Extract 5-80%

[0141] Sucrose 5.0-50%

[0142] Sodium cyclamate 5.0-40%

[0143] Methyl sorbate 0.001-2%

[0144] Distilled water 10-90%.

[0145] Preferred Prescription:

[0146] Ji Chuan Jian Extract 8.0g

[0147] Sucrose 1.0g

[0148] Sodium cyclamate 0.5g

[0149] Methyl sorbate 0.002g

[0150] Distilled water to make up to 20ml.

[0151] Preparation method: Prepare the Jichuanjian extract according to the method in Example 1, add the excipients of the prescription and distilled water, then ultrafilter through an ultrafilter, fill the ultrafiltrate, and sterilize to obtain the product.

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PUM

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Abstract

The invention relates to a Jichuan Decoction oral preparation for treating constipation due to kidney deficiency and a preparation method thereof. The oral preparation is prepared from mixed extract (extract, dry powder or volatile oil) of angelica, achyranthes root, herba cistanches, alisma, bugbane rhizome and bitter orange fruit by mixing with pharmaceutically acceptable carrier or excipient as matrix and preparing into oral preparation by a conventional process. The preparation is effective in warming the kidney and replenishing essence and loosening the bowel to relieve constipation, and is mainly used for treating constipation, clear abundant urine, weakness of waist and knees etc. Long-term clinical application shows that the preparation has good therapeutic effect to functional constipation due to deficiency of the kidney and essence.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a preparation method of an oral preparation of a therapeutic drug for mainly treating kidney deficiency and constipation, in particular to an extract of a traditional Chinese medicine made by Ji Chuan Jian as the active ingredient of the drug, and has the effect of warming the kidney and replenishing essence. Oral preparation, and the present invention also relates to a preparation method of the medicine. Background technique [0002] "Jichuan Jian" is a famous prescription created by Zhang Jingyue, a physician in the Ming Dynasty, in "Jingyue Quanshu". It has always been used as a representative prescription for treating yang deficiency and constipation. Warming the kidney and benefiting the essence, moistening the intestines and laxative effect, it is mainly used to cure constipation, clear and long urination, soreness of the waist and knees, etc. In the thirty-fourth volume of...

Claims

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Application Information

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IPC IPC(8): A61K36/68A61K9/48A61K9/20A61K9/16A61K9/10A61K9/28A61K9/46A61K47/38A61K47/34A61K47/32A61P13/12A61P1/10A61K47/10
Inventor 张文芳
Owner 苏州世林医药技术发展有限公司
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