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Methods and formulations for modulating Lyn kinase activity and treating related disorders

A disease, nephropathy technology, applied in the field of regulating Lyn kinase activity and treating related diseases and preparations, can solve problems such as lack of general utility for regulating lipid insulin and glucose levels

Active Publication Date: 2008-10-15
MELIOR DISCOVERY INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

None of the currently commercially available drugs for modulating lyn kinase or controlling elevated blood glucose levels have general utility for regulating blood lipid, lipoprotein, insulin and glucose levels

Method used

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  • Methods and formulations for modulating Lyn kinase activity and treating related disorders
  • Methods and formulations for modulating Lyn kinase activity and treating related disorders
  • Methods and formulations for modulating Lyn kinase activity and treating related disorders

Examples

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Embodiment 1

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Embodiment 3

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Abstract

The present invention relates to compounds and pharmaceutically acceptable salts thereof and formulations comprising the compounds or a pharmaceutically acceptable salts thereof that are useful in modulating lyn kinase activity. In particular, the compounds or a pharmaceutically acceptable salts thereof are useful for treating or preventing a disease or disorder including cardiovascular disease, dyslipidemia, dyslipoproteinemia, a disorder of glucose metabolism, metabolic syndrome (i.e., Syndrome X), a peroxisome proliferator activated receptor-associated disorder, septicemia, a thrombotic disorder, type II diabetes, obesity, pancreatitis, hypertension, renal disease, inflammation, or impotence.

Description

Methods and preparations for regulating Lyn kinase activity and treating related disorders Cross reference to related applications This application claims the benefits of the co-pending U.S. Provisional Patent Application 60 / 709,798 filed on August 22, 2005 and the U.S. Provisional Patent Application 60 / 808,533 filed on May 26, 2006, which are incorporated herein by reference in their entirety. . 1. Field of Invention The present invention relates to compositions and preparations containing therapeutic or preventive active compounds or pharmaceutically acceptable salts thereof, methods for modulating Lyn kinase activity, and methods for treating Lyn kinase-related disorders. Specifically, the preparation is used for the treatment or prevention including cardiovascular disease, dyslipidemia, dyslipoproteinemia, glucose metabolism disorder, metabolic syndrome (ie Syndrome X), peroxisome proliferator activated receptor Related disorders, sepsis, thrombotic disorders, type II diabet...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/495A61P3/04
Inventor A·雷奥姆M·S·萨波里托
Owner MELIOR DISCOVERY INC
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