Compound niacin norfloxacin injection for animals and preparation thereof

A technology of norfloxacin nicotinic acid and injection, which is applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, digestive system, etc., which can solve the problem of reducing bacterial resistance and sensitivity, prolonging the use time, and increasing the number of medications Dosage and other issues, to reduce the secretion of gastrointestinal glands, increase sensitivity, reduce the frequency and dosage of medication

CN101297813BInactive Publication Date: 2010-09-01TIANJIN SHENGJI GRP CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Publication Date
2010-09-01
Estimated Expiration
Not applicable · inactive patent
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Abstract

The invention discloses a veterinary compound norfloxacin nicotinate injection and a preparation method thereof, which aims at providing the veterinary compound norfloxacin nicotinate injection that has rapid onset of action for the treatment for white diarrhea of piglets and can prevent the infection and the secondary infection and treat both manifestation and root cause of disease, and the preparation method that has simple technology and easy realization. In the veterinary compound norfloxacin nicotinate injection, each 100l injection is prepared by the following components: 1 to 8kg of the norfloxacin nicotinate, 2 to 10kg of lincomycin hydrochloride, 0.05 to 0.5kg of atropine sulfate, 0.2kg of sodium sulfite, 0.01kg of EDTA-2Na and the rest of water for injection. By adopting a compound preparation which combines anti-bacterial drugs and antibiotics for usage, and the combining usage of the norfloxacin nicotinate, the lincomycin hydrochloride and the atropine sulfate, the injection of the invention has rapid onset of action for white diarrhea of piglets, effectivity and high efficiency and can ease the stress reactions of the affected animals, significantly ease the clinical symptoms caused by the white diarrhea of piglets, treat both manifestation and root cause of disease, prevent the secondary infection and increase the weight of the pigs.
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Description

technical field

[0001] The invention relates to a veterinary compound norfloxacin nicotinic acid injection and a preparation method thereof. Background technique

[0002] Piglet pullorum is a common disease in pigs, which can cause diarrhea in piglets, with grayish-white and paste-like feces symptoms, which can cause poor growth and weight loss in piglets, and decreased resistance can cause secondary infection and death. Piglet pullorum is mainly caused by Escherichia coli, also known as delayed colibacillosis. It has a high incidence and is highly contagious. Usually, if one piglet gets sick, it will cause the whole litter of piglets to get sick.

[0003] At present, the drugs used in the treatment of pullorum in piglets, such as norfloxacin nicotinate and lincomycin hydrochloride, etc., due to the drug resistance and reduced sensitivity of bacteria, use alone will reduce the therapeutic effect, some even have no therapeutic effect, and some It will cause other diseases du...

Examples

Embodiment 1

[0021] (1) Weigh 1 kg of norfloxacin nicotinate and put it into 10 L of water for injection, stir for 10-25 min, and completely dissolve until clear.

[0022] (2) Put 10kg of lincomycin hydrochloride into 30L of water for injection, stir for 10-25min, and dissolve it completely until clear, then add 0.05kg of atropine sulfate, 0.2kg of sodium sulfite, and 0.01kg of EDTA-2Na in sequence, and stir until completely dissolved .

[0023] Add the solution prepared in step 1 and step 2 to 100L of water for injection, stir evenly, keep for 15-20min, and prepare the veterinary compound norfloxacin nicotinic acid injection of the present invention after the liquid is clear.

Embodiment 2

[0025] (1) Weigh 1.5kg of norfloxacin nicotinic acid into 15L of water for injection, stir for 10-25min, and completely dissolve until clear.

[0026] (2) Put 9kg of lincomycin hydrochloride into 30L of water for injection, stir for 10-25min, and dissolve it completely until clear, then add 0.06kg of atropine sulfate, 0.2kg of sodium sulfite, and 0.01kg of EDTA-2Na in sequence, and stir until completely dissolved .

[0027] Add the solution prepared in step 1 and step 2 to 100L of water for injection, stir evenly, keep for 15-20min, and prepare the veterinary compound norfloxacin nicotinic acid injection of the present invention after the liquid is clear.

Embodiment 3

[0029] (1) Weigh 4 kg of norfloxacin nicotinic acid and put it into 25 L of water for injection, stir for 10-25 min, and completely dissolve until clear.

[0030] (2) Put 5kg of lincomycin hydrochloride into 25L of water for injection, stir for 10-25min, and dissolve it until clear, then add 0.3kg of atropine sulfate, 0.2kg of sodium sulfite, and 0.01kg of EDTA-2Na in sequence, and stir until completely dissolved .

[0031] Add the solution prepared in step 1 and step 2 to 100L of water for injection, stir evenly, keep for 15-20min, and prepare the veterinary compound norfloxacin nicotinic acid injection of the present invention after the liquid is clear.