Process for synthesizing remifentanil

A compound and reaction mixture technology, applied in the field of synthesizing remifentanil, can solve the problems of increasing raw material costs, reducing production efficiency, increasing method costs, etc.
CN101312949AInactive Publication Date: 2008-11-26MALLINCKRODT INC
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
MALLINCKRODT INC
Publication Date
2008-11-26
Estimated Expiration
Not applicable · inactive patent

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Abstract

An improved process for synthesizing opiate or opioid analgesics and anesthetics, and intermediates thereof is provided. In particular, processes of synthesizing intermediates for use in the preparation of synthetic opiate or opioid compounds such as, for example, remifentanil, carfentanil, sufentanil, fentanyl, and alfentanil are disclosed. The preparation process requires fewer steps, and results in reduced costs and higher efficiency than processes known in the art for producing remifentanil and carfentanil.
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Description

field of invention In general, the present invention relates to methods of synthesizing opiate or opioid analgesics and anesthetics and precursors thereof. In particular, the present invention relates to methods for the synthesis of intermediates used in the preparation of synthetic opiates or opioid compounds such as remifentanil, carfentanil, sufentanil fentanyl, fentanyl and alfentanil. In particular, the present invention relates to methods of preparation which require fewer steps, reduce costs and result in higher efficiencies compared to methods known in the art for the preparation of remifentanil and carfentanil. Background of the invention Analgesics, such as remifentanil and carfentanil, have been prepared using synthetic methods involving 6 and 7 steps. Examples of these methods are listed in US Patent Nos. 5,106,983 and 5,019,583. However, these syntheses often require multiple protection and deprotection steps for the active moiety, leading to increased proces...

Claims

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