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Preparation of arilin slow-release medicine-membrane for tooth

A technology of metronidazole teeth and metronidazole, which is applied in the production field of metronidazole dental slow-release drug film, can solve the problems of large dosage of medicine, poor medical effect, and large side effects, and achieve high drug concentration and high test effect. Slow, long-lasting effect

Inactive Publication Date: 2009-02-04
宋信平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In order to solve the problems of oral tablet metronidazole for the treatment of periodontal disease, the dosage of medicine is large, the medical effect is poor, and the side effects are large, a kind of absorbable metronidazole drug film with polymer material as the slow-release carrier is invented

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Example 1, 10.71 grams of metronidazole, 28.58 grams of sodium carboxymethylcellulose, 2.85 grams of polyvinyl alcohol-12444, and 17.86 grams of starch. First soak 42.85 grams of polyvinyl alcohol-124 and 28.58 grams of sodium carboxymethyl cellulose for 10 hours to dissolve respectively, and grind 10.71 grams of metronidazole and 17.86 grams of starch with water, then mix the above-mentioned 42.85 grams of polyvinyl alcohol-124, 28.58 gram carboxymethylcellulose sodium, 10.71 gram metronidazole, and 17.86 gram starch gelatinous liquid are mixed and stirred evenly; then add preservatives and sodium saccharin, dilute with distilled water to form an easy-to-apply paste, and spread it on a flat board. Thin layer, dry naturally to form a film.

Embodiment 2

[0011] Example 2, take 21.42 grams of metronidazole, 57.16 grams of sodium carboxymethylcellulose, 5.70 grams of polyvinyl alcohol-12485, and 35.72 grams of starch. First soak 85.70 grams of polyvinyl alcohol-124 and 57.16 grams of sodium carboxymethyl cellulose for 14 hours to dissolve, and grind 21.42 grams of metronidazole and 35.72 grams of starch with water, then mix the above-mentioned 85.70 grams of polyvinyl alcohol-124, 57.16 gram carboxymethyl cellulose sodium, 21.42 gram metronidazole, 35.72 gram starch colloidal solution, mix and stir evenly; then add preservatives, saccharin sodium, dilute with distilled water and reconcile into a paste that is easy to smear, spread out on a flat board Thin layer, dry naturally to form a film.

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Abstract

The invention relates to the preparation of a metronidazole dental sustained-release film which is characterized in that the components of the film contain: 10.71% of metronidazole standard, 28.58 % of sodium carboxymethyl cellulose, 42.85% of polyvinyl alcohol-124, and 17.86% of starch. The invention solves the problems of big medicine dosage, poor medical effects and big side effects when oral tablets metronidazole cures parodontopathy, and is widely used by parodontopathy patients.

Description

technical field [0001] The invention relates to the field of preparations of medical drugs, in particular to a preparation method of a metronidazole dental slow-release film. Background technique [0002] At present, in drug treatment of periodontal disease, it is mainly completed by taking metronidazole tablet orally. Its disadvantages are that the dosage of the drug is large, the concentration of the drug in the local periodontal area is low, the medical effect is poor, and it is highly irritating to the gastrointestinal tract. Contents of the invention [0003] In order to solve the problems of large dosage, poor medical effect and large side effects of oral metronidazole in the treatment of periodontal disease, the present invention invents an absorbable metronidazole drug film using polymer material as a slow-release carrier. [0004] The technical solution of the present invention is the preparation of a metronidazole dental slow-release film, the composition of whic...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K31/4164A61P1/02
Inventor 宋信平王勇孟华王敏金正明乔永杰王静业
Owner 宋信平
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