Sticking tablet for curing mouth ulcer using mometasone furoate as active component

A technology of an active ingredient and an adhesive patch, which is applied in the field of an adhesive patch for treating oral ulcers with mometasone furoate as an active ingredient, and achieves the effect of overcoming potential hazards

Active Publication Date: 2011-06-15
TIANJIN PHARMA GROUP CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And above-mentioned several kinds of plasticizers are mainly used in the purposes such as the packaging of food and drug in the prior art, and do not use it for the report of plasticizer in drug coating

Method used

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  • Sticking tablet for curing mouth ulcer using mometasone furoate as active component

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Paste the slice

[0025] Mometasone furoate 0.1g

[0026] Carbomer 10g

[0027] Dextrin 30g

[0028] Magnesium stearate 0.03g

[0029] The protective layer

[0030] L100-55 4g

[0031] Titanium dioxide 1g

[0032] Yellow iron oxide 1g

[0033] Acetyl tributyl citrate (ATBC) 0.8g

[0034] Preparation Process:

[0035] Dissolve mometasone furoate with 5ml of absolute ethanol, add the above active ingredient solution to the dextrin that has passed through a 100-mesh sieve and mix well, then granulate through a 30-mesh sieve, dry at 60°C, and then pass it through a 40-mesh sieve. After adding carbopol and magnesium stearate that have passed through a 100-mesh sieve and mixing them thoroughly, they are compressed with a flat punch with a diameter of 6 mm to obtain 1000 tablets, each containing 0.10 mg mometasone furoate. The prescription amount L100-55 is dissolved in 95ml of 95% ethanol, and the prescription amount of ATBC, titanium dioxide, yellow iron oxide i...

Embodiment 2

[0037] In the formula of Example 1, the active ingredient was changed to mometasone furoate 0.2g, and the plasticizer was changed to tributyl citrate (TBC). Other preparation processes were the same as in Example 1.

Embodiment 3

[0039] Paste the slice

[0040] Mometasone furoate 0.5g

[0041] Carbomer 5g

[0042] Polyvinylpyrrolidone (PVP) 3g

[0043] Dextrin 30g

[0044] Magnesium stearate 0.05g

[0045] The protective layer

[0046] L100-55 4g

[0047] Titanium dioxide 0.5g

[0048] Trihexyl citrate (THC) 0.8g

[0049] Preparation Process:

[0050] Dissolve mometasone furoate with an appropriate amount of absolute ethanol, add the above-mentioned active ingredient solution to the dextrin passed through a 100-mesh sieve and mix well, then granulate through a 30-mesh sieve, dry at 60°C, and then pass it through a 40-mesh sieve. Add carbomer, PVP, and magnesium stearate that have passed through a 100-mesh sieve, and then press them with a flat punch with a diameter of 6 mm to obtain 1000 tablets. The prescription amount is 0.5 mg containing methylprednisolone. L100-55 is dissolved in 95ml of 95% ethanol, added with the prescribed amount of THC and titanium dioxide to grind uniformly, and spray evenly on the surface...

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Abstract

The invention relates to a sticking tablet used for treating human or animal dental ulcer; the oral sticking tablet consists of an adhesive layer containing active components and a water insoluble protective layer; the inactive component containing in the adhesive layer consists of a filling agent, an adhesive sustained-released agent and a lubricant that are applicable to tablet, and the water insoluble protective layer consists of polyacrylic acid resin and / or ethyl cellulose which can be used as protective coatings and a plasticizer, and the active component is momestasone furoate.

Description

Technical field: [0001] The invention relates to a pharmaceutical composition for treating oral ulcers in humans or mammals and applications thereof, in particular to an oral adhesive tablet Background technique: [0002] Oral ulcers are also called recurrent aphthous ulcers, commonly known as aphthous ulcers, and are a common oral mucosal membrane disease. Recurrent oral ulcer refers to a type of unexplained, recurrent but self-limiting, isolated, round or oval ulcer. It is also called recurrent aphthous ulcer (aphthous means "burning and ulcer formation" in Greek) or recurrent aphthous ulcers. Clinically, ulcers can be divided into three types according to the size, depth, and number of ulcers: recurrent mild oral ulcers, recurrent stomatitis ulcers and recurrent necrotizing mucosal gland inflammation. [0003] Recurrent oral ulcers are one of the most common diseases in oral mucosal diseases. In a person’s life, there are almost no oral ulcers that do not occur. It is only occ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/573A61K9/70A61K47/32A61K47/34A61K47/38A61K47/40A61P1/02
Inventor 李静张其婉李宏铃马晓勇陈松胡筱芸
Owner TIANJIN PHARMA GROUP CORP
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