Compositions and methods relating to treatment of cancer and infectious diseases

A composition and compound technology, applied in the direction of drug combination, anti-infective drug, pharmaceutical formulation, etc.

Inactive Publication Date: 2009-03-25
都柏林伊丽莎白女皇神学院院长、研究员及专家协会
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Results to date have shown that this therapy enhances the anti-tumor immune response, but has no real indication of preventing tumor growth, although data in mouse models suggest a possible effect (Micronnel, I., S. et al. 2002 .J Immunol 168:1212)

Method used

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  • Compositions and methods relating to treatment of cancer and infectious diseases
  • Compositions and methods relating to treatment of cancer and infectious diseases
  • Compositions and methods relating to treatment of cancer and infectious diseases

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Embodiment Construction

[0171] naive CD4 + T cells can differentiate into effector Th1 or Th2 cells or Treg cells, and the selective induction of these different subtypes may be determined by many factors, including the degree of maturation of dendritic cells (DCs) and regulatory cytokines secreted by cells of the autoimmune system . Some pathogen-derived immunomodulatory molecules such as TLR ligands promote the induction of Th1 cells. Molecules of other pathogenic origin, such as FHA and Cya from B. pertussis and CT, promote the induction of Tr cells either selectively or together with Th2 cells. The simultaneous induction of Treg cells and effector T cells may be a host protective strategy to control excessive Th1 and Th2 responses, thereby limiting pathogen-induced inflammation and immunopathology. The induction of Th1 cells by TLR ligands is related to their function to promote the production of IL-12 and IL-27 from self cells, especially macrophages and DCs. However, TLR ligands have also be...

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Abstract

The present invention provides methods for modulating an immune response by administering a composition comprising a Toll-iike receptor agonist and an immune mediator which downregufates the expression of the anti-inflammatory cytokine IL-10 and upregulates the expression of the pro-inflammatory cytokine IL-12. The methods can be used to provide therapeutic treatment for cancerous conditions and infectious diseases.

Description

technical field [0001] The present invention relates to novel compositions and methods for the prevention or treatment of cancer or malignant diseases as well as infectious diseases. In particular, the present invention relates to a composition and method for promoting the induction of type 1 immune responses, such as Th1 cells, and / or disrupting regulatory T (Treg) cells. The present invention further extends the application of the composition of the present invention to the treatment of diseases. Background technique [0002] Autoimmune system cells, especially dendritic cells (DCs), dominate naive CD4 + T cells differentiate into functionally distinct Th1, Th2 or regulatory T (Treg) cell subtypes. The activation of immature DCs caused by the binding of conserved microbial molecules to pathogen recognition receptors (PRRs) such as Toll-like receptors (TLRs) and cohesin, is accompanied by maturation and homing to lymph nodes. Mature DCs in lymph nodes present antigen (A...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/39A61K39/00
CPCA61K39/0011A61K39/39A61P31/00A61P35/00A61P43/00
Inventor 金斯敦·米尔斯迪尔德丽·托米安德鲁·亚尼克
Owner 都柏林伊丽莎白女皇神学院院长、研究员及专家协会
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