The invention discloses an isolation air exchange mechanism based on a medical protection device in the infectious disease treatment process. The isolation air exchange mechanism comprises an isolation room, a storage battery, a solar cell panel, a protective suit, a control panel and an air blower. An inner interlayer is arranged on the inner side of the protective suit, an air exchange opening is installed in the surface of the protective suit in a sewn mode, and one end of the air exchange opening extends to the interior of the protective suit. Driving wheels are fixedly installed at the four corners of the bottom end of the isolation room, the storage battery is fixedly installed on one side of the top end of the isolation room, the solar cell panel is transversely and fixedly installed at the top end of the storage battery, and an air exchange plug is fixedly installed at the top end of the portion, located on one side of the storage battery, of the isolation room. According to the isolation air exchange mechanism based on the medical protection device in the infectious disease treatment process, due to the fact that the air exchange opening and an air exchange connector are arranged, the air exchange process is simple, convenient and fast, the safety is high, the gas in the outside world is prevented from entering the mechanism, the safety of the medical staff is furtherimproved, and the influence of the hot gas on the medical staff is reduced.