40 results about "Infectious diseases treatment" patented technology

A self-contained device is described that integrates nucleic acid extraction, specific target amplification and detection into a single device. This integration permits rapid and accurate nucleic acid sequence detection. The invention may be used, for example, in the screening for nucleic acid sequences which may be indicative of genetic defects or contagious diseases, as well as for monitoring efficacy in the treatment of contagious diseases.

The invention relates to a preparation method of the completely humanized antibody of a infectious disease pathogen, which mainly comprises the following steps of: preparing an infectious disease pathogen antigen; fluorescently labeling an infectious disease pathogen antibody; concentrating and purifying the peripheral B cells of an infectious disease patient; combining the labeled pathogen antigen and the antigenic-specificity B cells; screening antigenic-specificity single B cells through a flow cytometer; carrying out single cell RT-PCR (Reverse Transcription-Polymerase Chain Reaction) amplification on genes positioned in the heavy chain and light chain variable region of the infectious disease pathogen antibody; connecting with a heavy chain and light chain constant region to construct the eukaryotic expression vector of the humanized antibody; and carrying out the high-efficiency expression and purification of a recombined antibody in an eukaryotic cell. The humanized monoclonal antibody prepared through the method disclosed by the invention can be used for the infectious disease diagnosis and the infectious disease treatment.

The invention depicts a portable gene detecting device integrating nucleic acid extraction, specific target nucleic acid amplification and detection. The integral device only needs to be uncovered once in the whole process during sampling adding and is then sealed so that target nucleic acid amplification products can be prevented from leaking out and causing contamination. The device conducts detection and result judgment and read in the visible form of naked eyes, is easy to operate, wide in sample application range and convenient to carry, can be used for detection on the first site of epidemic situation, is suitable for early diagnosis of various pathogens and respiratory infectious disease, and is used for screening out possible nucleotide sequences of genetic disease or infectious disease and monitoring infectious disease treatment efficiency.

The invention discloses an application of polypeptide in preparing preparations for preventing and treating human papilloma virus infection, and belongs to the field of infectious disease treatment. Apolypeptide preparation for preventing and treating human papilloma virus infection is also provided; and the polypeptide preparation takes the polypeptide with effective dose as active ingredients and is prepared by adding pharmaceutically acceptable subsidiary materials or auxiliary components. The polypeptide can be used for the treatment and prevention of human papilloma virus infection, so that the polypeptide is significant in effect; and the polypeptide has no inhibition effects on the normal flora of female genital tracts, so that the polypeptide is good in safety.

The present invention provides methods for modulating an immune response by administering a composition comprising a Toll-like receptor agonist and an immune mediator which downregufates the expression of the anti-inflammatory cytokine IL-10 and upregulates the expression of the pro-inflammatory cytokine IL-12. The methods can be used to provide therapeutic treatment for cancerous conditions and infectious diseases.

The invention discloses application of polypeptide in preparing a medicine for treating enterovirus infection, belongs to the field of infectious disease prevention and treatment, further provides a medicinal composition for treating enterovirus infection, and in addition, provides a polypeptide preparation prepared from pharmaceutically acceptable auxiliary materials or auxiliary components. The medicinal composition comprises an effective dosage of the polypeptide as an active component. The polypeptide disclosed by the invention can be used for treating enterovirus infection, particularly for treating and preventing hand-foot-mouth diseases and herpetic herpangina, and is remarkable in effect and good in security.

The present invention relates to a class of pleuromytilin compounds represented by the following general formula (I), pharmaceutically acceptable salts and preparation methods thereof, and compositions comprising the compound represented by the general formula (I) as an active component. The compounds have excellent antibacterial activities and can be adopted as the active substance for infectious disease treatment.

The invention discloses a negative-pressure isolating helmet and relates to the field of infectious disease treatment and transportation. The negative-pressure isolating helmet comprises a helmet body, a half-length gown, an air exhaust hose and an air exhaust filtration system, wherein the helmet body is arranged on the half-length gown; the helmet body and the half-length gown are in air-tightness connection with each other; the helmet body is connected with the air exhaust filtration system through the air exhaust hose; and a one-way air inlet valve is arranged at the top of the helmet body. The negative-pressure isolating helmet disclosed by the invention is used for an infectious patient and the interference in the free movement of the infectious patient is avoided; the normal unrestricted movements of the head and the neck of a wearer are guaranteed; and the negative-pressure isolating helmet is convenient to carry because the size of the air exhaust filtration system is small.

A pharmaceutical composition to be administered to mammals via the mucosal route consisting of a vehicle system comprising mono- / dietherglycerides conjugated with a water soluble polymer groups selected from PEG's containing 2-30 polyoxyethylene units, an antigen and optionally a bacterial toxin for the augmentation of immune responses for vaccination, immunisation, treatment of allergy, treatment of cancer, treatment of infectious disease, treatment of an autoimmune disease, Alzheimer's, substance addiction or the treatment of a disease which is fully or partially controlled by the body immune system.

The present invention contemplates provision of a quinolone antibacterial agent and a drug for the treatment of infectious diseases, which exhibit potent antibacterial activity and higher selective toxicity against Gram-positive and Gram-negative bacteria, which do not cause side effects (e.g., convulsion), and which exhibit higher safety. A compound represented by the following formula (I): a salt of the compound, or a hydrate of the compound or the salt; and an antibacterial drug and an infectious disease treating drug containing the compound as an active ingredient.

The invention relates to a Chinese herbal medicinal fermented extract liquid for preventing and treating bacterial diseases of freshwater fish and a preparation method of the Chinese herbal medicinal fermented extract liquid. The Chinese herbal medicinal fermented extract liquid is prepared by adding a bacillus bacterium liquid to a traditional Chinese medicinal extract liquid for airtight anaerobic fermentation. The traditional Chinese medicine is prepared from the following components in parts by weight: 2-5 parts of coptis chinensis, 3-6 parts of cortex phellodendri, 5-10 parts of humifuse euphorbia herb, 1-2 parts of fructus forsythia and 1-3 parts of liquorice. The Chinese herbal medicinal fermented extract liquid belongs to a natural medicine, is free of toxic or side effect, low in treatment cost, high in recovery rate, safe, and convenient to use, and is mainly used for treating main bacterial infectious diseases of the freshwater fish.

The invention relates to application of a platycodon root total saponin to medicaments for treating and preventing mycoplasma pneumoniae infectious diseases, and relates to application of platycodon root total saponin to medicaments. The platycodon root total saponin is used as the active ingredient of the medicaments for treating and preventing the mycoplasma pneumoniae infectious diseases, and is a composition of one or more of saponins of platycogenic acid, polygalic acid, platycogenic acid and platycogenic acid A lactone. The platycodon root total saponin has the effect of resisting mycoplasma pneumoniae; in-vitro experiments indicate that a minimal inhibitory concentration (MIC) value of resisting mycoplasma pneumoniae (MP) is between 16 and 64 mu g / ml, and the minimal bactericidal concentration (MBC) is between 64 to 128 mu g / ml; and in-vivo experiments indicate that after 8 mg / Kg and 16 mg / Kg of platycodon root total saponins are subjected to intragastric administration on BALB / C mice subjected to MP injection by nasal dropping for 10 days, the pathological injury of lungs of the mice can be relieved obviously, and the immunologic function of organisms is regulated, so the platycodon root total saponin has a treatment effect on the MP infection.

The invention discloses a cleaning device for an infectious disease treatment tool, and relates to the technical field of medical devices. The device comprises a cleaning box and a protective shell fixed on the right side wall of the cleaning box, wherein a supporting frame is vertically fixed at the bottom of the cleaning box, a servo motor is fixed on the supporting frame, a sealing sleeve extending into the cleaning box is movably arranged on a driving shaft in a sleeve mode, the sealing sleeve is fixedly provided with an inner stirring frame, the surface of the sealing sleeve is fixedly provided with a bevel gear I in a sleeve mode, and a bevel gear II meshing with a bevel gear III and the bevel gear I is rotationally installed at the bottom of the cleaning box. According to the cleaning device, the rotary stirring effect of a cleaning liquid in the cleaning box is achieved through mutual reverse rotation of an outer stirring frame and the inner stirring frame, sufficient contact between a medical instrument and the cleaning liquid is promoted, the sufficient flushing effect on the instrument is realized, a storage net basket loaded with the medical instrument can move up and down in cleaning box in a reciprocating mode, so that shaking of components is realized, the rinsing effect on the medical instrument is realized, and cleaning on the instrument is more sufficient andmore efficient.

The invention discloses a clinical pharmacist anti-infection consultation follow-up visit database management system, comprising a computer, a processor, a memorizer, and a patient basic information entry module, a patient consultation information entry module, a patient infection state analysis module, a patient antibacterial agent use statistics module, a consultation advise and follow-up visitdata entry module which are connected with the memorizer. The clinical pharmacist anti-infection consultation follow-up visit database management system provided by the invention fills a blank of a research field, the clinical pharmacist anti-infection consultation data can be effectively managed and stored, the system is convenient to be popularized and applied to local and similar area medical institutions, an integrated and standardized data platform is provided for future data mining, an effect of clinical pharmacist anti-infection consultation on infectious disease treatment can be effectively evaluated, an evidence support is provided for pharmacist performance management and after-effect evaluation, and the clinical pharmacist consultation service quality is improved.

The invention belongs to the field of medicine technology, more specifically relates to carbapenems antibiotics, and pharmaceutically acceptable salt, hydrolyzed ester, isomer, hydrate, hydrate of ester or salt thereof shown in the general formula (I), wherein, R1, R2, R3 and ring A are defined in the specification; the invention also relates to the preparation method of compounds, and pharmaceutical composition containing the compounds, and purposes of the compounds in preparation of medicaments for infectious disease treatment and / or prevention.

There are disclosed a novel α-amino-N-(diaminophosphinyl)lactam derivative represented by general formula (1):wherein, for example, A is a hydrogen atom or a substituent such as a lower alkyl group or the like; W, X, Y and Z are independently a hydrogen atom or a substituent such as a lower alkyl group, aryl group, arylacyl group, arylaminocarbonyl group or the like; and Q is —(CH2)n— wherein n is 0 to 3, or its salt, and a therapeutic agent and a prophylactic agent for myelosuppression, a therapeutic agent for infectious diseases, an agent for increasing the number of leukocytes and a dipeptidyl peptidase IV inhibitor which comprise the above-mentioned derivative or salt thereof as an active ingredient.

Provided herein are methods of sorting antigen-specific IgM memory B cells (MBCs), compositions and methods comprising such antigen-specific IgM MBCs, and recombinant antibody or antigen-binding fragments isolated from such antigen-specific IgM MBCs. As demonstrated herein, IgM and IgD MBCs are unique populations of cells with distinct phenotypic, functional and survival properties. Accordingly, the antigen-specific IgM MBCs and antibodies and antigen-binding fragments derived from these cells described herein are useful in therapeutic applications in vaccine strategies and treatment of infectious diseases.

The invention relates to the technical field of atomization inhalation treatment, and in particular, relates to an atomization inhaler for infectious diseases, wherein the atomization inhaler comprises an inhalation mask, a liquid medicine tank and a waste liquid tank; a liquid storage cavity is formed in the upper portion of the liquid medicine tank, an oxygen vent pipe is fixedly arranged in the liquid storage cavity, and one end of the oxygen vent pipe penetrates through the liquid medicine tank and is fixedly connected with a compressor; the lower end of a waste liquid outlet pipe runs through the waste tank and is fixedly communicated with the upper cavity; and a connecting guide pipe is arranged between the waste liquid tank and the liquid medicine tank, one end of the connecting guide pipe is fixedly connected with the compressor, the other end of the connecting guide pipe is fixedly connected and communicated with the lower cavity, and an oxygen generating assembly is arranged in the lower cavity. The atomization inhaler is used for atomization treatment of infectious diseases, the mode of directly introducing air or canning oxygen is abandoned, oxygen is generated in a chemical reaction mode, the hygiene of exhaled oxygen is guaranteed by preparing oxygen in a closed environment, meanwhile, waste liquid and waste gas are disinfected through reaction heat, waste heat can also be used for guaranteeing the temperature of exhaled oxygen, and the comfort is improved.

The invention relates to a prevention and control method for infectious disease treatment. According to the method, an infectious disease prevention and treatment hospital is divided into a polluted area, a semi-polluted area, a buffer area and a clean area; airflow distribution, pressure gradient and other measures are established in each area; and a medical staff entering process, a medical staff leaving process, a patient hospitalization process, a patient discharging process, a clean article entering process and a dirt discharging process are set as fixed processes. With the method, infectious diseases can be effectively treated, prevented and controlled, and spreading and spreading of the infectious diseases among patients, medical staff and social staff can be avoided to a great extent.

The invention relates to a Chinese herbal medicine fermentation extracting solution for preventing and controlling fungal diseases of freshwater fish and a preparation method thereof. The Chinese herbal medicine fermentation extracting solution is prepared by adding bacillus solution into a traditional Chinese medicine extracting solution through airtight anaerobic fermentation, wherein traditional Chinese medicines include, by weight, 2-4 parts of gallnuts, 2-3 parts of chenopodium ambrosioides, 5-8 parts of bitter shrubalthea barks, 1-2 parts of sophora flavescens, 1-2 parts of pomegranate peels and 2-5 parts of Chinese rhubarbs. The Chinese herbal medicine fermentation extracting solution is a natural medicine, is free of toxic and side effects, is mainly used for treating main bacterial infectious diseases of the freshwater fish and is low in treating cost, high in cure rate, safe and convenient to take.

The invention belongs to the technical field of traditional Chinese medicine cores and particularly relates to a scent bag medicine core capable of preventing infectious diseases. The scent bag medicine core capable of preventing infectious diseases mainly solves the technical problem that an existing infectious disease treatment method brings large mental and economic burdens to patients. According to the technical scheme, the scent bag medicine core capable of preventing infectious diseases is prepared from, by weight, 10-15 parts of honeysuckle, 6-12 parts of wrinkled giant hyssop, 6-12 parts of eupatorium, 5-10 parts of cloves, 6-12 parts of cyrtomium fortunei, 6-10 parts of folium artemisiae argyi, 6-10 parts of amomum tsaoko, 5-10 parts of amomum cardamomum, 5-10 parts of fructus amomi, 10-15 parts of acorus gramineus, 10-15 parts of polygala tenuifolia, 5 parts of cinnamon, 3 parts of borneol and 6-10 parts of evodia rutaecarpa. The scent bag medicine core has a very good curative effect on preventing and treating respiratory system infectious diseases, flu, hand, foot and mouth diseases, mumps, chicken pox, bird flux and the like and will not bring large mental and economic burdens to patients.

The invention discloses an operating table for infectious disease treatment experiments. The operating table comprises a base, a disinfectant storage box, universal wheels, an operation table body, adriving mechanism, a detector, a handrail, a disinfection part, a door body I, a conveying pump, a bracket, a pipeline I and a pipeline II, wherein the universal wheels are assembled at the four corners of the bottom end of the base correspondingly; the handrail is assembled on the side face of the base; the disinfection part is arranged on the left side of the top end of the base; the operation table body is arranged on the right side of the top end of the base and connected with the disinfection part; the door body I is assembled on the side surface of the operation table body through a pinshaft; the support is arranged in an inner cavity of the operation table body; and the conveying pump is assembled at the top end of the support. The operating table is convenient for intensively disinfecting a large number of instruments after experiment operation, has a good disinfection effect, can meet the requirements of medical disinfection, realizes adjustment of experiment detection instruments, performs experiment detection through the detector, and is easy to use and convenient for medical personnel to operate.

The present invention provides methods for modulating the immune response of a subject to a therapeutic agent, the method comprising administering an effective amount of a triphenylethylene (TRIP) compound with an effective amount of the therapeutic agent. In particular embodiments, the TRIP compound enhances the immune response of the subject to the therapeutic agent. In some embodiments, the TRIP compound is administered in different dosing schedules to provide a biphasic immunomodulation effect.

The invention discloses an isolation air exchange mechanism based on a medical protection device in the infectious disease treatment process. The isolation air exchange mechanism comprises an isolation room, a storage battery, a solar cell panel, a protective suit, a control panel and an air blower. An inner interlayer is arranged on the inner side of the protective suit, an air exchange opening is installed in the surface of the protective suit in a sewn mode, and one end of the air exchange opening extends to the interior of the protective suit. Driving wheels are fixedly installed at the four corners of the bottom end of the isolation room, the storage battery is fixedly installed on one side of the top end of the isolation room, the solar cell panel is transversely and fixedly installed at the top end of the storage battery, and an air exchange plug is fixedly installed at the top end of the portion, located on one side of the storage battery, of the isolation room. According to the isolation air exchange mechanism based on the medical protection device in the infectious disease treatment process, due to the fact that the air exchange opening and an air exchange connector are arranged, the air exchange process is simple, convenient and fast, the safety is high, the gas in the outside world is prevented from entering the mechanism, the safety of the medical staff is furtherimproved, and the influence of the hot gas on the medical staff is reduced.

The invention discloses a South American tree frog host defense peptide DMS-PS2 and its gene and application, belonging to the field of biomedicine. The host defense peptide DMS‑PS2 is a polypeptide consisting of 28 amino acids with a molecular weight of 2953.5 Daltons. The gene encoding the DMS‑PS2 precursor peptide (GenBank: LT718217.1) consists of 346 nucleotide sequences, of which the 136‑228th nucleotide sequence is the gene encoding the DMS‑PS2 mature peptide, which is further post-translationally modified to obtain Mature peptide DMS‑PS2. The DMS-PS2 of the present invention has broad-spectrum antibacterial activity, has strong antibacterial effect on free bacteria and bacterial biofilm, and its mode of action is to directly act on bacterial biofilm to make bacterial plasma membrane broken, so it is not easy to produce bacterial drug resistance It provides a theoretical basis for the development of therapeutic drugs against infectious diseases and coating drugs for medical devices.

The present invention relates to antibody molecules that bind to Wall Teichoic Acid (WTA) or Capsular Polysaccharides (CP) such as Capsular Polysaccharides type 5 (CP5). The invention relates in particular to antibody molecules of the IgG isotype having a mutation in the Fc domain that enhances clustering of IgG molecules after target binding. The invention also relates to pharmaceutical compositions containing these molecules and the treatment of infectious diseases using these compositions